Association of the T-cell Regulatory Ggene CTLA-4 with Suscep-tibility to Autoimmune Thyroid Disease in Population of Novosibirsk

Nikitin, Yu. P.; Рымар, О. Д.; Максимов, В. Н.; Šimonová, Gabriela; Zankina, M; Мустафина, С. В.; Sherbacova, L; Чернова, Н. Н.; Voevoda, M.

doi:10.14341/ket20084441-45

Cited by 3 publications

(5 citation statements)

References 21 publications

(24 reference statements)

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“…Выявлена связь носительства аллеля G и генотипа GG полиморфизма A49G гена CTLA4 с повышенным риском развития ДТЗ у мужчин [6]. Носительство аллеля T полиморфизма C1858T гена PTPN22 у жен-щин ассоциировано с повышенным риском разви-тия АИТ [7].…”

Section: обоснованиеunclassified

“…По данным проведенных ранее исследований в г. Новосибирске, у мужчин носительство аллеля G и генотипа GG полиморфизма A49G гена CTLA4 ассо циировано с повышенным риском развития ДТЗ, у женщин такой связи не было обнаружено [7].…”

Section: результатыunclassified

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Association of candidate gene polymorphisms for autoimmune thyroid diseases in patients with familial diffuse toxic goiter and autoimmune thyroiditis

et al. 2016

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Section: результатыunclassified

Association of candidate gene polymorphisms for autoimmune thyroid diseases in patients with familial diffuse toxic goiter and autoimmune thyroiditis

et al. 2016

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“…Using the Fas / FasL system, apoptosis is also an important means to destroy the cytotoxic T cells. [20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

The activity of proliferation and apoptosis of thyrocytes in the thyroid tissue of patients of nodular goiter with autoimmune thyroiditis considering the polymorphism of the BCL-2 (RS17759659), CTLA-4 (RS231775), APO-1/FAS (RS2234767) genes

Шеремет¹,

Sydorchuk²,

Shidlovskyі³

et al. 2020

Biointerface Res Appl Chem

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Nodular goiter with autoimmune thyroiditis is one of the most important problems of modern endocrinology, with inadequately studied etiological and pathogenic mechanisms of development. It is characterized by the lack of objective and reliable diagnostic methods, effective treatment methods, uncertain therapy or indications for the choice of treatment methods. A total we have examined 125 patients who were operated for a nodular endemic goiter with autoimmune thyroiditis. Investigated the activity of proliferation and apoptosis of thyrocytes in the thyroid tissue of patients of nodular goiter with autoimmune thyroiditis considering the polymorphism of the bcl-2 (rs17759659), ctla-4 (rs231775), apo-1/fas (rs2234767) genes. The expression/density markers - Fas/ FasL, Bcl-2, p53 and Ki-67 on the thyrocytes in the lymphoid infiltration and destruction areas, as well as in normal thyroid tissue (as a control) were studied. The number of immunoreactive cells, which expressed the above-mentioned regulating apoptosis and proliferation markers in NGAIT patients, depending on the genes polymorphism BCL-2 (rs17759659), CTLA-4 (rs231775) and APO-1/Fas (rs2234767) were counted. It was found that in NGAIT patients a few links of programmable thyroid cell killing of Fas-induced apoptosis were activated, and associated with the polymorphic cite of BCL-2 (rs17759659) gene and almost 6 times weaker with CTLA-4 (rs231775) gene, through enhanced expression of Fas and Fas L on the cells surface in lymphoid infiltration and destruction areas (stronger in GG genotype carriers of BCL-2 gene).

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“…However, several immunological alterations have been found in these patients, such as HLA-DR antigen expression in thyrocytes, the presence of growth-stimulating immunoglobulins, and an increase in dendritic cells and lymphocytes, which suggest the possibility of autoimmune problems (1,(8)(9)(10). Although many of these findings may be an epiphenomenon of other primary defects in immunoregulation, the alteration of lymphocyte populations indicates a primary defect (6,7,10,(12)(13)(14)(15)(16)(17)(18). Variations in several genes have been studied as possible risk factors for Hashimoto thyroiditis.…”

Section: Introductionmentioning

confidence: 99%

“…AIT thought to result from a combination of genetic and environmental factors (1)(2)(3)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Some of these factors have been identified, but many remain unknown (19)(20)(21)(22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

Molecular-genetic mechanisms in development of degree of function and hyperplasia of thyroid gland of patients with nodular goiter with autoimmune thyroiditis and thyroid adenoma

Шеремет¹,

Sydorchuk²,

Shidlovskyі³

et al. 2019

Ro J Med Pract.

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Introduction. Autoimmune thyroiditis affects in average 2% to 5% of the general population, with young adult females and the elderly being the most vul-nerable patients. Hashimoto's thyroiditis causing hypothyroidism is the most prevalent etiology. Although genetics is well known to cause and influence the progression of autoimmune diseases in approximately 79%, other environmental factors are known to be involved in the development of autoimmune thyroid dis-eases: quantity of ingested iodine, stress, drugs, pregnancy, and changes in sexual hormones.Autoimmune thyroiditis, as a background disease of nodular goiter, in which hypothyroidism usually develops, has been insufficiently studied.Material and methods. The BCL-2 (rs17759659), CTLA-4 (rs231775), Fas (rs2234767) genes' polymorphism were studied by Real-Time Polymerase Chain Reaction in 95 patients with NGAIT, 30 patients with thyroid adenoma (TA) and 25 healthy individuals. The thyroid gland (TG) functional activity changes (nor-mal function, subclinical and clinical hypothyroidism) and TG hyperplasia degrees (IB, II and III) were analyzed.Results. TA and NGAIT are more common in the minor G-allele carriers (GА-and GG-genotypes) of the BCL-2 gene and in homozygous G allele patients (GG-genotype) of the Fas gene by 11.5 and 4.34 times (р<0.01), with no signifi-cant interdependence between the CTLA4 gene's genotypes. TG hyperplasia in patients' general cohort as well as in those with NGAIT is associated with the wild A alleles of the CTLA-4 gene (АА-and AG-genotypes): the І and ІІІ degree hy-perplasia occurred reliably more frequently in the AA genotype carriers, and ІІ degree of the TG enlargement in the AG genotype patients.Conclusions. Pathology of the thyroid gland has unreliable chances to be inherited depending on the polymorphism of BCL-2 (rs17759659), CTLA-4 (rs231775) and Fas (rs2234767) genes in Bukovina region (Western Ukraine). We did not find any difference between the relative incidences of the genotypes of the analyzed genes in the patients with NGAIT and those with TA or depending on the TG function (euthyroid goiter, subclinical and clinical hypothyroidism)..

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Association of the T-cell Regulatory Ggene CTLA-4 with Suscep-tibility to Autoimmune Thyroid Disease in Population of Novosibirsk

Cited by 3 publications

References 21 publications

Association of candidate gene polymorphisms for autoimmune thyroid diseases in patients with familial diffuse toxic goiter and autoimmune thyroiditis

Association of candidate gene polymorphisms for autoimmune thyroid diseases in patients with familial diffuse toxic goiter and autoimmune thyroiditis

The activity of proliferation and apoptosis of thyrocytes in the thyroid tissue of patients of nodular goiter with autoimmune thyroiditis considering the polymorphism of the BCL-2 (RS17759659), CTLA-4 (RS231775), APO-1/FAS (RS2234767) genes

Molecular-genetic mechanisms in development of degree of function and hyperplasia of thyroid gland of patients with nodular goiter with autoimmune thyroiditis and thyroid adenoma

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