Association of the serum irisin level with obstructive sleep apnea: a body mass index- and physical activity-matched study

Abstract

1), 2), 3) , Yupu Liu 1), 2), 3) , Huajun Xu 1), 2), 3) , Huaming Zhu 1), 2), 3) , Jian Guan 1), 2), 3) , Hongliang Yi 1), 2), 3) and Jianyin Zou 1), 2), 3)

Cardiometabolic health, visceral fat and circulating irisin levels: results from a real-world weight loss study

“…The relationship of plasma irisin concentration with chronic exercise training or habitual PA is controversial as both increasing [ 37 ] and decreasing [ 38 ] levels of this myokine have been observed. Likewise, contradictory evidence has been shown associating irisin levels with CMRFs, including blood lipids, anthropometric parameters, and fat mass [ 14 , 15 , 39 ]. In our study, circulating irisin was correlated with adiposity measures but, in general, these correlations were weak.…”

“…Studies of other effects of this myokine in humans have yielded conflicting results. Some but not all reports suggested a possible role of irisin in the modulation of glucose [ 9 , 10 ] and lipid metabolism [ 11 , 12 ] as well as its correlation with weight, surrogate measures of adiposity such as BMI and waist circumference (both negative [ 14 ] and positive [ 15 ]), and level of physical activity [ 16 ]. Based on these suggestions we hypothesized that in obese individuals, life style improvement and weight reduction might influence plasma levels of this myokine.…”

Los colores del tejido adiposo y la relación con la irisina

“…En pacientes con obesidad, la irisina se encuentra disminuida y se asocia negativamente con la circunferencia de la cintura 32 . En pacientes con apnea obstructiva del sueño, de manera independiente del índice de masa corporal (IMC), la irisina se asocia con la apnea 37 , por lo que se ha propuesto que la irisina podría ser una molécula mensajera entre un eje formado por los tejidos muscular, adiposo y cerebral 37 . Aún más, otras investigaciones en modelos experimentales han mostrado que la irisina influye en la neurogénesis del hipocampo y en la diferenciación neural 37 .…”

Effect of Interaction Between Slow Wave Sleep and Obstructive Sleep Apnea on Insulin Resistance: A Large-Scale Study

“…OSA increases the risk of cardiovascular, cerebrovascular, and metabolic diseases, leading to loss of work and death among middle-aged and elderly people. 3 In addition, sleep fragmentation can cause daytime sleepiness, which then increases the incidence of related traffic accidents. Therefore, OSA has become an important public health problem.…”