Association of the s allele of the 5-HTTLPR with neuroticism-related traits and temperaments in a psychiatrically healthy population

Gonda, Xénia; Fountoulakis, Konstantinos Ν.; Juhász, Gabriella; Rihmer, Zoltán; Lazáry, Judit; Lászik, András; Akiskal, Hagop S.; Bagdy, György

doi:10.1007/s00406-008-0842-7

Cited by 136 publications

(93 citation statements)

References 38 publications

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“…this investigation inspired many subsequent attempts at replication. the results have been inconsistent with studies supporting (Gonda et al 2009) and not supporting (Willis-Owen et al 2005) this finding. the majority of these studies were underpowered, with sample sizes being small relative to what is needed to draw conclusions based on the small effect size that can be attributed to a single gene.…”

Section: Serotonin Transporter Imaging and Post-mortem Studies Of Suicontrasting

confidence: 70%

Serotonergic modulation of suicidal behaviour: integrating preclinical data with clinical practice and psychotherapy

Boulougouris

Malogiannis

Lockwood³

et al. 2013

Exp Brain Res

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Section: Serotonin Transporter Imaging and Post-mortem Studies Of Suicontrasting

confidence: 70%

Serotonergic modulation of suicidal behaviour: integrating preclinical data with clinical practice and psychotherapy

Boulougouris

Malogiannis

Lockwood³

et al. 2013

Exp Brain Res

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“…Because neuroticism is related to the 5-HTTLPR polymorphism and s-carriers have high levels of neuroticism (Greenberg et al, 2000;Lesch et al, 1996), the interaction between neuroticism and adult stressful life events might be partly explained by the 5-HTTLPR GxE interaction (Caspi et al, 2003). Other personality traits shown on tests such as the Temperament and Character Inventory (TCI) and the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego auto-questionnaire version (TEMPS-A) are related to neuroticism and the 5-HTTLPR polymorphism (Gonda et al, 2009). The items on the TEMPS-A, formulated on the basis of the diagnostic criteria for affective temperaments, are divided into five groups as follows: the cyclothymic, depressive, irritable and hyperthymic groups based on the subscales representing the Kraepelinian temperaments, and the anxious group, based on the subscale developed secondarily by Akiskal and coworkers Akiyama et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

The influence of childhood abuse, adult stressful life events and temperaments on depressive symptoms in the nonclinical general adult population

Nakai

Inoue

Toda

et al. 2014

Journal of Affective Disorders

101

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Background: Previous studies have shown the interaction between heredity and childhood stress or life events on the pathogenesis of major depression. We hypothesized that childhood abuse, affective temperaments, and adult stressful life events interact and influence depressive symptoms in the general adult population and tested this hypothesis in this study. Methods:The 294 participants from the nonclinical general adult population were studied using the Limitations:The subjects of this study were nonclinical. The findings might not be generalized to patients with mood disorders. Conclusions:This study suggests that childhood abuse, especially neglect, indirectly increased depressive symptoms through increased affective temperaments, which, in turn, increase the negative appraisal of stressful life events. An important role of affective temperaments in the effect of childhood abuse and stressful life events on depressive symptoms was suggested.

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“…Likewise carriers of the low expressing alleles (any S or L G (S/L G )) have more depressive and anxious symptoms (Caspi et al, 2003), and more depressive and anxious symptoms relative to carriers of the L A L A allele (Canli & Lesch, 2007;Gonda et al, 2009). There is also some evidence indicating that carriers of the low expressing S allele rate higher in NE than LL carriers (Auerbach et al, 1999;Hayden et al, 2010;Hayden et al, 2007).…”

Section: The Role Of Genotypementioning

confidence: 99%

Prenatal maternal depression and child serotonin transporter linked polymorphic region (5-HTTLPR) and dopamine receptor D4 (DRD4) genotype predict negative emotionality from 3 to 36 months

et al. 2016

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Prenatal maternal depression and a multilocus genetic profile of two susceptibility genes implicated in the stress response were examined in an interaction model predicting negative emotionality (NE) in the first 3 years. In 179 mother-infant dyads from the Maternal Adversity, Vulnerability and Neurodevelopment cohort, prenatal depression (CES-D) was assessed at 24 to 36 weeks. The multilocus genetic profile score consisted of the number of susceptibility alleles from 5-HTTLPR (No L A (S/S, S/L G or L G /L G ) vs. any L A ) and Dopamine Receptor D4 (6-8R vs. 2-5R). NE was extracted from the IBQ-R at 3 and 6 months and the ECBQ at 18 and 36 months. Mixed and confirmatory regression analyses indicated that prenatal depression and the multilocus genetic profile interacted to predict NE from 3 to 36 months. Results were characterised by a differential susceptibility model at 3 and 6 months and by a diathesis stress model at 36 months. Negative emotionality (NE) is derived from the temperamental dimensions of sadness, distress towards limitations, fear and excessive reactions to minor changes, and reflects a generally stable tendency to show increased emotional reactivity towards negative situations (Gartstein & Rothbart, 2003;Lemery, Goldsmith, Klinnert, & Mrazek, 1999). NE is associated with the development of later problematic behaviour and psychopathology (Eisenberg et al., 2009;Fox, Henderson, Rubin, Calkins, & Schmidt, 2001;Hyde, Mezulis, & Abramson, 2008). For example, fearful temperament is associated with childhood anxiety disorders (Degnan, Alma, & Fox, 2010;Goldsmith & Lemery, 2000), while NE is associated with depression (Phillips, Lonigan, & Driscoll, 2002) and maladjustment (Eisenberg et al., 2009). Understanding early influences of NE on socio-emotional development (Davis, Glynn, Schetter, Hobel, Chicz-demet, & Sandman, 2007;Davis, Snidman, Glynn, Dunkel Schetter, & Sandman, 2004;Hayden et al., 2010;Hayden et al., 2007) could inform efforts at prevention and early intervention. Recent contradictory findings about the role of genetic and prenatal adversity (Braithwaite et al., 2013;, suggest the need for replication (Duncan, 2013) and modeling of genetic risk with multiple genes (Plomin, 2013). Accordingly, we present the findings from a study of the development of NE from 3 to 36 months of age from the interaction of prenatal maternal depression and a multilocus genetic profile. The Role of Prenatal Maternal StressPrenatal maternal stress, measured in diverse ways is associated with NE (Glover, 2011;O'Connor, Heron, & Glover, 2002a). For example, higher prenatal maternal cortisol is associated with fussier behaviour, more negative facial expressions, crying, as well as higher NE at 7 weeks of age (de Weerth, Hees, & Buitelaar, 2003). Symptoms of prenatal maternal anxiety and depression, loosely associated with the stress response predict behavioural reactivity at 4 months of age (Davis et al., 2004) and behavioural/emotional problems at 4 years of age (O'Connor, et al., 2002a). While most studi...

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Association of the s allele of the 5-HTTLPR with neuroticism-related traits and temperaments in a psychiatrically healthy population

Cited by 136 publications

References 38 publications

Serotonergic modulation of suicidal behaviour: integrating preclinical data with clinical practice and psychotherapy

Serotonergic modulation of suicidal behaviour: integrating preclinical data with clinical practice and psychotherapy

The influence of childhood abuse, adult stressful life events and temperaments on depressive symptoms in the nonclinical general adult population

Prenatal maternal depression and child serotonin transporter linked polymorphic region (5-HTTLPR) and dopamine receptor D4 (DRD4) genotype predict negative emotionality from 3 to 36 months

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