Association of the rs3743205 variant of DYX1C1 with dyslexia in Chinese children

Lim, Cadmon K.P.; Ho, Connie Suk‐Han; Chou, Crystal Hin Ning; Waye, Mary Miu Yee

doi:10.1186/1744-9081-7-16

Cited by 37 publications

(40 citation statements)

References 43 publications

(70 reference statements)

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“…Most previous molecular genetics studies examined the genetic mechanism of orthographic skills on the behavioral level (Lim, Ho, Chou, & Waye, 2011; Lind, et al, 2010; Scerri, 2004; Zhang, et al, 2012). While some reading-related genetic studies on dyslexia investigated how genetic variation influences auditory language processing at the neural level (Czamara, et al, 2010; Roeske, et al, 2011), only one study looked at neurogenetic effects in a visual word processing task (Pinel, et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Gene–environment interaction on neural mechanisms of orthographic processing in Chinese children

Wang

Maurer

et al. 2015

Journal of Neurolinguistics

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The ability to process and identify visual words requires efficient orthographic processing of print, consisting of letters in alphabetic languages or characters in Chinese. The N170 is a robust neural marker for orthographic processes. Both genetic and environmental factors, such as home literacy, have been shown to influence orthographic processing at the behavioral level, but their relative contributions and interactions are not well understood. The present study aimed to reveal possible gene-by-environment interactions on orthographic processing at the behavioral and neural level in a normal children sample. Sixty 12 year old Chinese children from a 10-year longitudinal sample underwent an implicit visual-word color decision task on real words and stroke combinations. The ERP analysis focused on the increase of the occipito-temporal N170 to words compared to stroke combinations. The genetic analysis focused on two SNPs (rs1419228, rs1091047) in the gene DCDC2 based on previous findings linking these 2 SNPs to orthographic coding. Home literacy was measured previously as the number of children's books at home, when the children were at the age of 3. Relative to stroke combinations, real words evoked greater N170 in bilateral posterior brain regions. A significant interaction between rs1091047 and home literacy was observed on the changes of N170 comparing real words to stroke combinations in the left hemisphere. Particularly, children carrying the major allele “G” showed a similar N170 effect irrespective of their environment, while children carrying the minor allele “C” showed a smaller N170 effect in low home-literacy environment than those in good environment.

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Section: Discussionmentioning

confidence: 99%

Gene–environment interaction on neural mechanisms of orthographic processing in Chinese children

Wang

Maurer

et al. 2015

Journal of Neurolinguistics

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“…The sample characteristics of these phenotypic measures have been described by Lim et al [11]. To be classified as children with dyslexia, their literacy composite score and at least one cognitive composite score had to be at least one standard deviation (SD = 3) below the mean (mean = 10) of their respective ages in the HKT-SpLD (cutoff score = 7).…”

Section: Methodsmentioning

confidence: 99%

A common haplotype of KIAA0319 contributes to the phonological awareness skill in Chinese children

Lim

Wong

et al. 2014

Behav Brain Funct

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BackgroundPrevious studies have shown that KIAA0319 is a candidate gene for dyslexia in western populations. In view of the different languages used in Caucasian and Chinese populations, the aim of the present study was to investigate whether there is also an association of KIAA0319 in Chinese children with dyslexia and/or to the language-related cognitive skills.Method and resultsA total of twenty six single nucleotide polymorphisms (SNPs) were genotyped from three hundred and ninety three individuals from 131 Chinese families. Four of the SNPs have been reported in the literature and twenty two being tag SNPs at KIAA0319. Analysis for allelic and haplotypic associations was performed with the UNPHASED program and multiple testing was corrected using permutation. Results indicate that KIAA0319 is not associated with Chinese children with dyslexia but a haplotype consisting of rs2760157 and rs807507 SNPs were significantly associated with an onset detection test, a measure of phonological awareness (p nominal = 6.85 10 -5 and p corrected = 0.0029).ConclusionIn conclusion, our findings suggest that KIAA0319 is associated with a reading-related cognitive skill.

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“…A False Discovery Rate (FDR <0.05) was used to control for testing of multiple genotypes and phenotypes, as described 27 and applied 28, 29 in the literature. A total of 6 phenotypes were tested for association: systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), (fasting) plasma glucose, total cholesterol, and HDL cholesterol.…”

Section: Methodsmentioning

confidence: 99%

Integrated Computational and Experimental Analysis of the Neuroendocrine Transcriptome in Genetic Hypertension Identifies Novel Control Points for the Cardiometabolic Syndrome

Friese

Yuan

Nievergelt

et al. 2012

Circ Cardiovasc Genet

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Background Methods and Results We developed a novel, integrative method (combining animal models, transcriptomics, bioinformatics, molecular biology, and trait-extreme phenotypes) to identify candidate genes for essential hypertension and the metabolic syndrome. We first undertook transcriptome profiling on adrenal glands from blood pressure extreme mouse strains: the hypertensive BPH and hypotensive BPL. Microarray data clustering revealed a striking pattern of global underexpression of intermediary metabolism transcripts in BPH. The MITRA algorithm identified a conserved motif in the transcriptional regulatory regions of the underexpressed metabolic genes, and we then hypothesized that regulation through this motif contributed to the global underexpression. Luciferase reporter assays demonstrated transcriptional activity of the motif, via transcription factors HOXA3, SRY, and YY1. We finally hypothesized that genetic variation at HOXA3, SRY, and YY1 might predict blood pressure and other metabolic syndrome traits in humans. Tagging variants for each locus were associated with BP in a human population BP extreme sample, with the most extensive associations for YY1 tagging SNP rs11625658, on SBP, DBP, BMI, and fasting glucose. Meta-analysis extended the YY1 results into two additional large population samples, with significant effects preserved on DBP, BMI, and fasting glucose. Conclusions The results outline an innovative, systematic approach to the genetic pathogenesis of complex cardiovascular disease traits, and point to transcription factor YY1 as a potential candidate gene involved in essential hypertension and the cardio-metabolic syndrome.

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Association of the rs3743205 variant of DYX1C1 with dyslexia in Chinese children

Cited by 37 publications

References 43 publications

Gene–environment interaction on neural mechanisms of orthographic processing in Chinese children

Gene–environment interaction on neural mechanisms of orthographic processing in Chinese children

A common haplotype of KIAA0319 contributes to the phonological awareness skill in Chinese children

Integrated Computational and Experimental Analysis of the Neuroendocrine Transcriptome in Genetic Hypertension Identifies Novel Control Points for the Cardiometabolic Syndrome

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