Association of the rs1760944 polymorphism in the <i>APEX1</i> base excision repair gene with risk of nasopharyngeal carcinoma in a population from an endemic area in South China

Lu, Zhaogeng; Li, Sisi; Ning, Sisi; Yao, Mei; Zhou, Xiao Qin; Wu, Yuan; Zhong, Changtao; Yan, Kui; Wei, Zhengbo; Xie, Ying

doi:10.1002/jcla.22238

Cited by 6 publications

(7 citation statements)

References 29 publications

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“…Li et al found that genotype rs1760944 GG was associated with reduced risk of NPC compared with other genotypes, but the results did not reach statistical significance. More recently, one study conducted by Lu et al confirmed that individuals with genotype rs1760944 GT or GG had significantly decreased NPC susceptibility than those with genotype rs1760944 TT [59]. These findings indicated that rs1760944 G allele may exert protective effects against several cancers.…”

Section: Discussionmentioning

confidence: 95%

APEX1 Polymorphisms and Neuroblastoma Risk in Chinese Children: A Three-Center Case-Control Study

Liu

Jia

Hua

et al. 2019

Oxidative Medicine and Cellular Longevity

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Neuroblastoma is a life-threatening extracranial solid tumor, preferentially occurring in children. However, its etiology remains unclear. APEX1 is a critical gene in the base excision repair (BER) system responsible for maintaining genome stability. Given the potential effects of APEX1 polymorphisms on the ability of the DNA damage repair, many studies have investigated the association between these variants and susceptibility to several types of cancer but not neuroblastoma. Here, we conducted a three-center case-control study to evaluate the association between APEX1 polymorphisms (rs1130409 T>G, rs1760944 T>G, and rs3136817 T>C) and neuroblastoma risk in Chinese children, consisting of 469 cases and 998 controls. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated to evaluate the associations. No significant association with neuroblastoma risk was found for the studied APEX1 polymorphisms in the single locus or combination analysis. Interestingly, stratified analysis showed that rs1130409 GG genotype significantly reduced the risk of tumor in males. Furthermore, we found that carriers with 1-3 protective genotypes had a lower neuroblastoma risk in the children older than18 months and male, when compared to those without protective genotypes. In summary, our data indicate that APEX1 gene polymorphisms may have a weak effect on neuroblastoma susceptibility. These findings should be further validated by well-designed studies with larger sample size.

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Section: Discussionmentioning

confidence: 95%

APEX1 Polymorphisms and Neuroblastoma Risk in Chinese Children: A Three-Center Case-Control Study

Liu

Jia

Hua

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…According to the major inclusion criteria, there were 20 papers (including 23 independent case–control studies) focusing on the relationship of APE1 rs1760944 T>G polymorphism with cancer risk [23–25,31–47]. Among them, five investigated lung cancer [24,31–33], three investigated colorectal cancer [34–36], three investigated breast cancer [37–39], three investigated cervical cancer [40,41], two investigated osteosarcoma [23], two investigated nasopharyngeal carcinoma [42,43] and five investigated other cancers (bladder cancer [44], glioblastoma [25], renal cell carcinoma [45], prostate cancer [46] and ovarian cancer [47]). Additionally, twenty-one had Asian and two had Caucasian ethnicities.…”

Section: Resultsmentioning

confidence: 99%

“…Since 2007, a number of case–control studies were performed to assess the potential relationship of APE1 rs1760944 T>G polymorphism with the risk of cancer, but the observations were controversial. Several investigations suggested that APE1 rs1760944 T>G SNP decreased the susceptibility of cancer [23,24,31,32,37,38,40,42,44,46]. However, other case–control studies suggest null correlation between the APE1 rs1760944 T>G SNP and cancer risk [25,33–36,39,41,43,45,47].…”

Section: Discussionmentioning

confidence: 99%

Association betweenapurinic/apyrimidinic endonuclease 1rs1760944 T>G polymorphism and susceptibility of cancer: a meta-analysis involving 21764 subjects

et al. 2019

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Background: Previous case–control studies have suggested that apurinic/apyrimidinic endonuclease 1 (APE1) rs1760944 T>G polymorphism may be associated with cancer risk. Here, we carried out an updated meta-analysis to focus on the correlation between APE1 rs1760944 T>G locus and the risk of cancer.Methods: We used the crude odds ratios (ORs) with their 95% confidence intervals (CIs) to evaluate the possible relationship between the APE1 rs1760944 T>G polymorphism and cancer risk. Heterogeneity, publication bias and sensitivity analysis were also harnessed to check the potential bias of the present study.Results: Twenty-three independent studies involving 10166 cancer cases and 11598 controls were eligible for this pooled analysis. We found that APE1 rs1760944 T>G polymorphism decreased the risk of cancer in four genetic models (G vs. T: OR, 0.87; 95% CI, 0.83–0.92; P<0.001; GG vs. TT: OR, 0.77; 95% CI, 0.69–0.86; P<0.001; GG/TG vs. TT: OR, 0.83; 95% CI, 0.77–0.89, P<0.001 and GG vs. TT/TG: OR, 0.85; 95% CI, 0.80–0.92, P<0.001). Results of subgroup analyses also demonstrated that this single-nucleotide polymorphism (SNP) modified the risk among lung cancer, breast cancer, osteosarcoma, and Asians. Evidence of publication bias was found in the present study. When we treated the publication bias with ‘trim-and-fill’ method, the adjusted ORs and CIs were not significantly changed.Conclusion: In conclusion, current evidence highlights that the APE1 rs1760944 T>G polymorphism is a protective factor for cancer susceptibility. In the future, case–control studies with detailed risk factors are needed to confirm or refute our findings.

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“…These data proved that cyclin D1 was an independent prognostic biomarker for NPC. In addition, genomic DNA damage may affect the susceptibility to NPC and be related with NPC progression, [34][35][36] so cyclin D1 as the positive prognostic marker in NPC could be interpreted as related to the amplification and deletion of other genes.…”

Section: Discussionmentioning

confidence: 99%

Upregulation of cyclin D1 can act as an independent prognostic marker for longer survival time in human nasopharyngeal carcinoma

Liu

Wang

et al. 2020

Clinical Laboratory Analysis

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Background Cyclin D1 is an essential part of oncogenic transformation. We previously proved that cyclin D1 was upregulated in nasopharyngeal carcinoma (NPC) and promoted the NPC cell proliferation. But the association between cyclin D1 and the clinical outcome of NPC has not yet been determined. The study explores the possible relevance between the cyclin D1 expression and clinical parameters and its predictive value of prognosis in NPC patients. Methods We analyzed the clinical data from 379 NPC patients and 112 non‐NPC patients in our previous study, which made further statistics. Receiver operating curve (ROC) was applied to select the optimal cutoff points. By analyzing the clinical data from 101 NPC patients using Chi‐squared test, we estimated the relationship between the cyclin D1 expression level and clinicopathological parameters. We also used Kaplan‐Meier method and log‐rank test assess and compared the disease‐free survival (DFS) rate and overall survival (OS) rate. The Cox proportional hazards model was adopted to perform the univariate and multivariate analyses. Result Receiver operating curve analysis reported that cyclin D1 was used to differentiate between NPC patients and non‐NPC patients ( P < .001, sensitivity: 53.6%, specificity: 85.7%, AUC = 0.752). Cyclin D1 was positively correlated with lymph node metastasis ( P = .015). A survival analysis of the 101 NPC patients indicated that the positive expression of cyclin D1 was predictive of a good prognosis (DFS: P = .010, OS: P = .019). Multivariate analysis showed that cyclin D1 could be used independently to predict NPC patients' prognosis (DFS: P = .038). Conclusion The overexpression of cyclin D1 is a good prognostic marker for NPC.

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Association of the rs1760944 polymorphism in the APEX1 base excision repair gene with risk of nasopharyngeal carcinoma in a population from an endemic area in South China

Abstract: Our results suggest that APEX1 rs1760944 polymorphism may correlate with NPC susceptibility in a population from an endemic area in South China.

Cited by 6 publications

References 29 publications

APEX1 Polymorphisms and Neuroblastoma Risk in Chinese Children: A Three-Center Case-Control Study

APEX1 Polymorphisms and Neuroblastoma Risk in Chinese Children: A Three-Center Case-Control Study

Association betweenapurinic/apyrimidinic endonuclease 1rs1760944 T>G polymorphism and susceptibility of cancer: a meta-analysis involving 21764 subjects

Upregulation of cyclin D1 can act as an independent prognostic marker for longer survival time in human nasopharyngeal carcinoma

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Association of the rs1760944 polymorphism in the APEX1 base excision repair gene with risk of nasopharyngeal carcinoma in a population from an endemic area in South China

Abstract: Our results suggest that APEX1 rs1760944 polymorphism may correlate with NPC susceptibility in a population from an endemic area in South China.

Cited by 6 publications

References 29 publications

APEX1 Polymorphisms and Neuroblastoma Risk in Chinese Children: A Three-Center Case-Control Study

APEX1 Polymorphisms and Neuroblastoma Risk in Chinese Children: A Three-Center Case-Control Study

Association betweenapurinic/apyrimidinic endonuclease 1rs1760944 T&gt;G polymorphism and susceptibility of cancer: a meta-analysis involving 21764 subjects

Upregulation of cyclin D1 can act as an independent prognostic marker for longer survival time in human nasopharyngeal carcinoma

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Association betweenapurinic/apyrimidinic endonuclease 1rs1760944 T>G polymorphism and susceptibility of cancer: a meta-analysis involving 21764 subjects