Association of the Precursor of Interleukin‐1β and Peritoneal Inflammation—Role in Pathogenesis of Endometriosis

Sikora, Justyna; Mielczarek‐Palacz, Aleksandra; Kondera-Anasz, Zdzisława

doi:10.1002/jcla.21944

Cited by 45 publications

(39 citation statements)

References 24 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One such pathology of the peritoneal cavity is endometriosis, a condition characterised by ectopic endometrial tissue on the peritoneum that affects 10% of women of reproductive age [108]. In addition to increases in their numbers, peritoneal macrophages obtained from women with endometriosis have heightened basal production of pro-inflammatory cytokines, including TNFa, IL-1b and IL-8, and exaggerated responses to stimulation with TLR ligands, such as LPS [109,110]. Endometrial lesions are rich in immune cells and, in particular, macrophages.…”

Section: Role Of Serous Cavity Macrophages In Non-cavity Conditionsmentioning

confidence: 99%

The biology of serous cavity macrophages

Bain

Jenkins

2018

Cellular Immunology

View full text Add to dashboard Cite

For decades, it has been known that the serous cavities, which include the peritoneal, pleural and pericardial cavities, harbour large numbers of macrophages. In particular, due to the ease of isolating these cells, the peritoneal cavity has been used as a convenient source of macrophages to examine many facets of macrophage biology over the last 50-60 years. Despite this, it is only recently that the true heterogeneity of serous cavity mononuclear phagocyte compartment, which includes macrophages and dendritic cells, has been revealed. Advances in technologies such as multi-parameter flow cytometry and the 'OMICs' revolution have uncovered the presence of distinct populations of mononuclear phagocytes in the serous cavities. Given that peritoneal macrophages have been implicated in many pathologies, including peritonitis, pancreatitis, endometriosis and acute liver injury, it is imperative to understand the biology of these cells. Here, we review the recent advances in understanding the identity, origin and function of discrete serous cavity mononuclear phagocyte subsets in homeostasis and how these may change when homeostasis is perturbed, focusing on peritoneal and pleural cavities and highlighting differences in the mononuclear phagocytes found in each.

show abstract

Section: Role Of Serous Cavity Macrophages In Non-cavity Conditionsmentioning

confidence: 99%

The biology of serous cavity macrophages

Bain

Jenkins

2018

Cellular Immunology

View full text Add to dashboard Cite

show abstract

“…Anaesthetised 6-12 week old C57BL/6J CD45.1 + CD45.2 + animals were exposed to a single dose of 9.5 Gy γ -irradiation, with all but the head and upper thorax of the animals being protected by a 2 inch lead shield. Animals were subsequently given 2-5×10 6 BM cells from sex matched or mismatched congenic CD45.2 + C57BL/6J animals by i.v. injection.…”

Section: Methodsmentioning

confidence: 99%

Origin and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages

Bain

Gibson

Steers

et al. 2019

Preprint

View full text Add to dashboard Cite

Macrophages reside in the body cavities where they maintain serosal homeostasis and provide immune surveillance. Peritoneal macrophages are implicated in the aetiology of pathologies including peritonitis, endometriosis and metastatic cancer thus understanding the factors that govern their behaviour is vital. Using a combination of fate mapping techniques, we have investigated the impact of sex and age on murine peritoneal macrophage differentiation, turnover and function. We demonstrate that the sexually dimorphic replenishment of peritoneal macrophages from the bone marrow, which is high in males and very low in females, is driven by changes in the local microenvironment that arise upon sexual maturation. Population and single cell RNAseq revealed striking dimorphisms in gene expression between male and female peritoneal macrophages that was in part explained by differences in composition of these populations. By estimating the time of residency of different subsets within the cavity and assessing development of dimorphisms with age and in monocytopenic Ccr2−/− mice, we demonstrate that key sex-dependent features of peritoneal macrophages are a function of the differential rate of replenishment from the bone marrow while others are reliant on local microenvironment signals. Importantly, we demonstrate that the dimorphic turnover of peritoneal macrophages contributes to differences in the ability to protect against pneumococcal peritonitis between the sexes. These data highlight the importance of considering both sex and age in susceptibility to inflammatory and infectious disease.

show abstract

“…viii) IL-1β. The overexpression of IL-1β has been identified in adenomyosis (46) and endometriosis (76), which is linked with an ability to transform acute inflammation to the chronic inflammation.…”

Section: Functional Pathways Of Adenomyosis Candidate Genesmentioning

confidence: 99%