Association of the MMP-9 polymorphism and ischemic stroke risk in southern Chinese Han population

Gao, Ning; Guo, Ting; Luo, Han; Tu, Guolong; Niu, Fanglin; Yan, Mengdan; Xia, Ying

doi:10.1186/s12883-019-1285-7

Cited by 14 publications

(15 citation statements)

References 21 publications

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“…Increasing studies demonstrated that polymorphisms of MMP9 were associated with cerebrovascular disease [25, 26]. A lot of studies demonstrated that MMP9 rs3787268 and rs3918242 may increase the risk of IS [27-30]. Simultaneously, Yi et al [31] also found that rs3918242 and rs3787268 were associated with hemorrhagic transformation in acute IS patients.…”

Section: Discussionmentioning

confidence: 99%

MMP9 rs17576 Is Simultaneously Correlated with Symptomatic Intracranial Atherosclerotic Stenosis and White Matter Hyperintensities in Chinese Population

Feng

Zhou

et al. 2020

Cerebrovasc Dis

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Purpose: The aim of this study was screening for single nucleotide polymorphisms (SNPs) associated with white matter hyperintensities (WMHs) in symptomatic intracranial atherosclerotic stenosis (sICAS) patients and exploring a possible connection in the genetic background between macrovascular disease and small vessel disease. Methods: There were 400 sICAS patients enrolled in the study. Fazekas scores were applied to WMH classification. Healthy controls were referred to 1,000 Genome Project and GeneSky company who provided 1,007 Chinese healthy controls. Fast target sequencing technology was used to select the SNPs of 102 genes related to the pathogenesis of sICAS in the sICAS patients. Results: The allele frequencies of 88 SNPs were significantly different between the sICAS group and the healthy controls (p < 0.05). The allele frequencies of 53 SNPs were significantly different between the sICAS patients with and without WMHs (p < 0.05). Further analysis found that matrix metalloproteinase 9 (MMP9) rs17576 was simultaneously related to sICAS and WMHs. The frequency of the rs17576 A allele was significantly lower in sICAS patients when compared to the normal controls (p = 0.03, OR [95% CI] = 0.75 [0.625–0.91]). Also, the frequency of the rs17576 genotypes was significantly different under codominant (p = 0.009), dominant (p = 0.014), and recessive (p= 0.023) models. The frequency of the rs17576 A allele was significantly higher in sICAS with WMH patients, compared to those without WMHs (p = 0.022, OR [95% CI] = 1.54 [1.06–2.22]); the frequency of the rs17576 genotypes was significantly different under codominant (p = 0.019) and recessive (p = 0.032) models. Logistic regression analysis showed that age, hypertension, and MMP9 rs17576 AA genotype were independent risk factors for sICAS with WMHs. Conclusion: MMP9 rs17576 may be simultaneously associated with the risk of sICAS and WMHs.

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Section: Discussionmentioning

confidence: 99%

MMP9 rs17576 Is Simultaneously Correlated with Symptomatic Intracranial Atherosclerotic Stenosis and White Matter Hyperintensities in Chinese Population

Feng

Zhou

et al. 2020

Cerebrovasc Dis

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“…Researches showed that MMP-9 is related to the susceptibility and development of some cardiovascular diseases such as coronary heart diseases (CHC), atherosclerosis, digestive system diseases such as gastric cancer, colorectal cancer, some liver diseases like NAFLD, HCC etc. [19][20][21]. Study [22] have found that MMP-9 has multiple gene polymorphism sites, among which the − 1562 C/T (rs3918242) SNP is located at the promoter polymorphism site, and is the most widely and deeply studied SNP site.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Matrix Metalloproteinase-9 1562C/T Polymorphism and Liver Diseases: A Meta-Analysis

Yang

Cheng

et al. 2021

Preprint

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Background Liver diseases have an adverse impact on human’s body and life, and many factors, such as viruses, genes, etc., are closely related to the occurrence and development of liver diseases. This study tries to explore the relationship between liver diseases and one of the genetic polymorphisms (MMP-9-1562 C/T polymorphism) by meta-analysis, to provide basis for the prevention and treatment of liver diseases and to promote the study of the mechanism of liver diseases by the exploration of etiology. Methods Relevant literatures from PubMed, EMBASE, Web of Science, CNKI, Chinese biomedical literature database and other databases were searched from building the database to Dec. 2020. Meta-analysis method was adopted and Review Manager 5.3 software was used for analysis. Results A total of 7 studies with 1415 cases and 1592 controls were included in this meta-analysis. A significant association between MMP-9-1562 C/T polymorphism and liver diseases in the homozygous and recessive models (TT vs CC: OR = 1.82,95%CI = 1.28–2.59, P = 0.0009; TT vs CT + CC: OR = 1.73,95%CI = 1.24–2.41, P = 0.001). However, no association in heterozygote and dominant models (CT vs CC: OR = 1.05, 95%CI = 0.76–1.45, P = 0.78; TT + CT vs CC: OR = 1.17, 95%CI = 0.82–1.67, P = 0.38). Conclusions Our meta-analysis suggested that the TT genotype of MMP-9-1562 C/T polymorphism might be associated with the risk of nonalcoholic fatty liver disease, hepatocellular carcinoma, and primary liver cancer. If these diseases are present, screening genotype of MMP-9 and aggressive treatment of the primary disease is necessary.

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“… 7 Epidemiology studies support that there are genetic factors associated with stroke, and gene polymorphisms may regulate the pathophysiological process of IS. 8 …”

Section: Introductionmentioning

confidence: 99%

Superoxide Dismutase Gene Polymorphism is Associated With Ischemic Stroke Risk in the China Dali Region Han Population

Yang

Xu³

et al. 2021

The Neurologist

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Background: Stroke is a serious cardiovascular disease, a major cause of disability and death in both developed and developing countries. Superoxide dismutases (SODs) are enzymes that catalyze the breakdown of superoxide into oxygen and hydrogen peroxide and play a key role in the antioxidant response. This study explored the relationship between single-nucleotide polymorphisms (SNPs) in SOD genes and the risk of ischemic stroke (IS) in the Chinese Han population of Dali City. Methods: For this case-control study, the authors enrolled 144 patients who had an IS and 128 healthy controls. The SNPs rs17880487 and rs80265967 of the SOD1 gene, rs4880 and rs2842960 of the SOD2 gene, and rs2695232 and rs7655372 of the SOD3 gene were detected through TaqMan polymerase chain reaction. Genotypes and allele frequencies of the 2 groups were compared. Odds ratio and 95% confidence intervals were calculated by unconditional logistic regression, and environmental factors were corrected with multivariate logistic regression analysis. Results: Rs7655372 of SOD3 was associated with a significantly increased risk of IS. Moreover, the A and GA genotypes of SNP rs7655372 were associated with increased risk of IS, whereas the A and GA genotypes were risk factors for IS. Furthermore, multivariate logistic regression analysis showed that the rs7655372 GA genotype is the independent risk factor for IS. Conclusion: The SOD3 gene rs7655372 locus polymorphism is a risk factor for IS in the Dali region.

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Association of the MMP-9 polymorphism and ischemic stroke risk in southern Chinese Han population

Cited by 14 publications

References 21 publications

<b><i>MMP9</i></b> rs17576 Is Simultaneously Correlated with Symptomatic Intracranial Atherosclerotic Stenosis and White Matter Hyperintensities in Chinese Population

<b><i>MMP9</i></b> rs17576 Is Simultaneously Correlated with Symptomatic Intracranial Atherosclerotic Stenosis and White Matter Hyperintensities in Chinese Population

Relationship Between Matrix Metalloproteinase-9 1562C/T Polymorphism and Liver Diseases: A Meta-Analysis

Superoxide Dismutase Gene Polymorphism is Associated With Ischemic Stroke Risk in the China Dali Region Han Population

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