Background
Liver diseases have an adverse impact on human’s body and life, and many factors, such as viruses, genes, etc., are closely related to the occurrence and development of liver diseases. This study tries to explore the relationship between liver diseases and one of the genetic polymorphisms (MMP-9-1562 C/T polymorphism) by meta-analysis, to provide basis for the prevention and treatment of liver diseases and to promote the study of the mechanism of liver diseases by the exploration of etiology.
Methods
Relevant literatures from PubMed, EMBASE, Web of Science, CNKI, Chinese biomedical literature database and other databases were searched from building the database to Dec. 2020. Meta-analysis method was adopted and Review Manager 5.3 software was used for analysis.
Results
A total of 7 studies with 1415 cases and 1592 controls were included in this meta-analysis. A significant association between MMP-9-1562 C/T polymorphism and liver diseases in the homozygous and recessive models (TT vs CC: OR = 1.82,95%CI = 1.28–2.59, P = 0.0009; TT vs CT + CC: OR = 1.73,95%CI = 1.24–2.41, P = 0.001). However, no association in heterozygote and dominant models (CT vs CC: OR = 1.05, 95%CI = 0.76–1.45, P = 0.78; TT + CT vs CC: OR = 1.17, 95%CI = 0.82–1.67, P = 0.38).
Conclusions
Our meta-analysis suggested that the TT genotype of MMP-9-1562 C/T polymorphism might be associated with the risk of nonalcoholic fatty liver disease, hepatocellular carcinoma, and primary liver cancer. If these diseases are present, screening genotype of MMP-9 and aggressive treatment of the primary disease is necessary.