Association of the MLXIPL/TBL2 rs17145738 SNP and serum lipid levels in the Guangxi Mulao and Han populations

Abstract

BackgroundThe rs17145738 single nucleotide polymorphism (SNP) near MLX interacting protein-like/transducin (beta)-like 2 (MLXIPL/TBL2) loci is associated with serum lipid levels, but the results are inconsistent in diverse ethnic/racial groups. The current study was to investigate the association of MLXIPL/TBL2 rs17145738 SNP and several environmental factors with serum lipid profiles in the Guangxi Mulao and Han populations.MethodsA total of 649 subjects of Mulao nationality and 712 participants of Han nationality aged 16–84 years were randomly selected from our previous stratified randomized samples. Genotyping was performed by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing.ResultsSerum apolipoprotein (Apo) B levels were higher in Mulao than in Han (P < 0.001). There were no significant differences in the genotypic and allelic frequencies of the MLXIPL/TBL2 rs17145738 SNP between the two ethnic groups or between males and females. The T allele carriers had higher triglyceride (TG) and ApoB levels in Mulao, and higher total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels in Han than the T allele non-carriers (P < 0.05 for all). Subgroup analyses showed that the T allele carriers had higher ApoB levels in both Mulao and Han females than the T allele non-carriers, but the T allele carriers had lower ApoB levels in Han males than the T allele non-carriers (P < 0.05, respectively). The T allele carriers in Han had higher TC, high-density lipoprotein cholesterol (HDL-C) levels and ApoA1/ApoB ratio and lower TG levels in males, and higher LDL-C levels and lower ApoA1/ApoB ratio in females than the T allele non-carriers (P < 0.05 for all). Serum TC levels in the combined population of the two ethnic groups and in Han, and HDL-C levels in Han males were correlated with genotypes (P < 0.05 for all). Serum lipid parameters were also correlated with several environmental factors (P < 0.05-0.01).ConclusionsThe association of MLXIPL/TBL2 rs17145738 SNP and serum lipid profiles is different between the Mulao and Han populations. There is a sex-specific association in the both ethnic groups.

Paraoxonase-1 (PON1) rs662 Polymorphism and Its Association with Serum Lipid Levels and Longevity in the Bama Zhuang Population

“…It is speculated that the influence of PON1 rs662 on lipid metabolism may be limited, similar to other lipid regulating genes such as phosphodiesterase 3A ( PDE3A ) rs7134375 [37], rs2954029 of the Tribbles homolog 1 (TRIB1) gene [38] and MLXIPL/TBL2 rs17145738 [39]. Although the effect of a sole gene can be small, multiple genes can produce larger effects.…”

Association between the XKR6 rs7819412 SNP and serum lipid levels and the risk of coronary artery disease and ischemic stroke

“…Methods for the detection of serum HDL-C, LDL-C, ApoA1, TC, ApoB, TG levels were referred to our previous study [19]. Serum lipid levels were tested using an autoanalyzer (Type 7170A; Hitachi Ltd., Tokyo, Japan) in the Clinical Science Experiment Center of the First Affiliated Hospital, Guangxi Medical University [20,21].…”

“…The levels of serum TG (0.56-1.70 mmol/L), ApoB (0.80-1.05 g/L), TC (3.10-5.17 mmol/L), LDL-C (2.70-3.10 mmol/L), ApoA1 (1.20-1.60 g/L), HDL-C (1.16-1.42 mmol/L), and the ApoA1/ApoB ratio (1.00-2.50) were defined as normal values at our Clinical Science Experiment Center. The diagnostic criteria of hyperlipidemia, hypertension, obesity, normal weight, and overweight were referred to previous studies [19][20][21][22][23][24]. Somebody who has been previously diagnosed with diabetes or people with 2 h postprandial plasma glucose ≥11.1 mmol/L or a fasting plasma glucose ≥7.0 mmol/L were defined as diabetic patients [25].…”

A common variant association study in ethnic Saudi Arabs reveals novel susceptibility loci for hypertriglyceridemia

“…The rs17145738 has been implicated in TG variations in normolipidemic individuals as well as dyslipidaemia (3,13,(47)(48)(49)(50). The encoded LAMC1 protein is thought to mediate the attachment, migration and organization of cells into tissue during embryonic development as a result of its interaction with other cellular matrix components.…”