Association of the <i>ADHIB<sup>*</sup>3</i> Allele With Alcohol‐Related Phenotypes in Trinidad

Ehlers, Cindy L.; Montane-Jaime, Karelia; Moore, Shelly; Shafe, Samuel; Joseph, Roma; Carr, Lucinda G.

doi:10.1111/j.1530-0277.2006.00298.x

Cited by 31 publications

(33 citation statements)

References 39 publications

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“…Participants were dichotomized as carriers of at least one protective, low-risk allele ( ADH1B*3 ) or non-carriers for main analyses, because modeling a cross-product gene-environment interaction using a three-category polymorphic genotype may increase false positive and false negative findings 33 and only a small number of participants in our sample (3%) carried two copies of the ADH1B*3 allele, similar to previous studies. 18,19 We note that ancillary analyses with a continuous genotype classification of the number (instead of presence) of ADH1B*3 alleles yielded the same pattern of significance of the interaction effects between ADH1B and drinking motives.…”

Section: Methodsmentioning

confidence: 59%

“…Further, study eligibility criteria required that all participants report alcohol consumption at least once in the past 30 days, thus the relationship between ADH1B*3 , drinking motives, and alcohol use among occasional or non-drinkers remains unknown. Given that the ADH1B*3 allele has been shown to protect against drinking among Blacks, 18,19 study eligibility criteria may have excluded potential carriers who refrain from alcohol use due to negative reactions following drinking. However, this potential bias due to exclusion of abstainers may be negligible given that the prevalence of ADH1B*3 was within Hardy-Weinberg equilibrium in our sample and matched those of other studies among Blacks (34 – 41%).…”

Section: Discussionmentioning

confidence: 99%

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Interaction between the ADH1B3* allele and drinking motives on alcohol use among Black college students

Zaso

Desalu

Kim

et al. 2017

The American Journal of Drug and Alcohol Abuse

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Background Black young adults have lower rates of alcohol use than other racial groups. Genetic factors may protect against drinking; specifically, the ADH1B*3 allele is present almost exclusively in Black populations and has been protective against alcohol use and alcohol use disorder. The protective effects of the ADH1B*3 allele, however, may differ as a function of alcohol-promoting cognitions. Objectives The current study examined whether ADH1B*3 moderated relations of drinking motives with alcohol consumption among Black college drinkers. Methods Participants were 241 undergraduate students of self-identified Black race (mean age = 20 years; 66% female) who reported consuming alcohol at least once in the past 30 days. Results ADH1B*3 was not significantly associated with drinking motives or drinking behaviors. However, significant, albeit small, interaction effects of ADH1B*3 with drinking motives on drinking behavior were found; presence of an ADH1B*3 allele protected against greater drinking quantity among students with high social motives (incidence rate ratio [IRR] = 0.95, 95% CI [0.92, 0.99]) and against frequent drinking among students with low coping motives (IRR = 1.06, 95% CI [1.01, 1.11]). Conclusion Such findings represent a novel demonstration of genetic modulation of alcohol-related cognitions within Black college drinkers, although replication is needed. Results represent an initial step toward better characterizing individual differences in associations of drinking motives with drinking behavior, with potential implications for interventions aimed at motivational processes in alcohol use.

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Section: Methodsmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Interaction between the ADH1B3* allele and drinking motives on alcohol use among Black college students

Zaso

Desalu

Kim

et al. 2017

The American Journal of Drug and Alcohol Abuse

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“…Among those participants who were alcohol dependent, ADH1B*3 was associated with significantly higher levels of the liver enzyme aspartate aminotransferase, which can be indicative of alcohol-induced liver disease. These analyses suggest that in this sample of Trinidadians, the ADH1B*3 allele has a protective effect against development of alcoholism; however, in people who do become alcohol dependent, the allele is associated with an enhanced risk for liver disease (Ehlers et al 2007).…”

Section: Frequencies Of Adh and Adh Alleles In Indo-and Afro-trinidadmentioning

confidence: 98%

“…Another analysis investigated the association of alleles of another type of ADH, ADH1B, with alcohol dependence, drinking history, and liver function in Indo-and AfroTrinidadians (Ehlers et al 2007). That study determined the frequencies of two alleles, ADH1B*2 and ADH1B*3.…”

Section: Frequencies Of Adh and Adh Alleles In Indo-and Afro-trinidadmentioning

confidence: 99%

Variations in alcohol-metabolizing enzymes in people of East Indian and African descent from Trinidad and Tobago

Jaime¹,

Moore²,

Carr³

et al. 2008

European Psychiatry

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The population of Trinidad and Tobago is composed mainly of people of East Indian (Indo-Trinidadians) and African (Afro-Trinidadians) ancestry. Differences in alcoholism rates exist between these two ethnic groups, and researchers have investigated whether these differences can be explained in part by variations in the genes encoding the alcohol-metabolizing enzymes alcohol dehydrogenase (ADH) 1B and 1C, and aldehyde dehydrogenase (ALDH) 1 and 2. Studies have demonstrated that a certain variant of the gene encoding ADH1B (ADH1B*3) is associated with a reduced risk of alcoholism in Afro-Trinidadians, as is a variant of the gene encoding ADH1C (i.e., ADH1C*1) in Indo-Trinidadians. An ALDH2 variant shown to have protective effects primarily in East Asians was not found in either Trinidadian ethnic group. However, a variant in the gene encoding cytosolic ALDH1A (i.e. ALDH1A1*1/*2) was found to be associated with an increase in alcohol dependence in Indo-Trinidadians.

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“…There is strong evidence for a negative association between the ADH1B*2 allele (i.e., A allele at rs1229984) and alcohol dependence and alcohol consumption (Ehlers et al, 2012;Konishi et al, 2004;Li et al, 2011;Macgregor et al, 2009), as well as evidence for the ADH1B*3 allele (i.e., T allele at rs2066702) (Edenberg et al, 2006;Ehlers et al, 2007). Bierut et al (2012) reported reduced risk for alcohol dependence for the A allele at rs1229984 versus the G/G genotype in a combined sample of European Americans and African Americans.…”

mentioning

confidence: 99%

Interactions Between Alcohol Metabolism Genes and Religious Involvement in Association With Maximum Drinks and Alcohol Dependence Symptoms

Chartier

Dick

Almasy

et al. 2016

J. Stud. Alcohol Drugs

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ABSTRACT. Objective: Variations in the genes encoding alcohol dehydrogenase (ADH) enzymes are associated with both alcohol consumption and dependence in multiple populations. Additionally, some environmental factors have been recognized as modifiers of these relationships. This study examined the modifying effect of religious involvement on relationships between ADH gene variants and alcohol consumption-related phenotypes. Method: Subjects were African American, European American, and Hispanic American adults with lifetime exposure to alcohol (N = 7,716; 53% female) from the Collaborative Study on the Genetics of Alcoholism. Genetic markers included ADH1B-rs1229984, ADH1B-rs2066702, ADH1C-rs698, ADH4-rs1042364, and ADH4-rs1800759. Phenotypes were maximum drinks consumed in a 24-hour period and total number of alcohol dependence symptoms according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Religious involvement was defined by self-reported religious services attendance. Results: Both religious involvement and ADH1B-rs1229984 were negatively associated with the number of maximum drinks consumed and the number of lifetime alcohol dependence symptoms endorsed. The interactions of religious involvement with ADH1B-rs2066702, ADH1C-rs698, and ADH4-rs1042364 were significantly associated with maximum drinks and alcohol dependence symptoms. Risk variants had weaker associations with maximum drinks and alcohol dependence symptoms as a function of increasing religious involvement. Conclusions: This study provided initial evidence of a modifying effect for religious involvement on relationships between ADH variants and maximum drinks and alcohol dependence symptoms. (J. Stud. Alcohol Drugs, 77, 393-404, 2016)

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Association of the ADHIB^3* Allele With Alcohol‐Related Phenotypes in Trinidad

Abstract: This study suggests, in this sample of Trinidadians, that the ADH1B(*)3 allele is associated with protection from the development of alcoholism but is also associated with enhanced risk for elevated serum ALT levels in those individuals who do become alcohol dependent.

Cited by 31 publications

References 39 publications

Interaction between the ADH1B3* allele and drinking motives on alcohol use among Black college students

Interaction between the ADH1B3* allele and drinking motives on alcohol use among Black college students

Variations in alcohol-metabolizing enzymes in people of East Indian and African descent from Trinidad and Tobago

Interactions Between Alcohol Metabolism Genes and Religious Involvement in Association With Maximum Drinks and Alcohol Dependence Symptoms

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Association of the ADHIB*3 Allele With Alcohol‐Related Phenotypes in Trinidad

Abstract: This study suggests, in this sample of Trinidadians, that the ADH1B(*)3 allele is associated with protection from the development of alcoholism but is also associated with enhanced risk for elevated serum ALT levels in those individuals who do become alcohol dependent.

Cited by 31 publications

References 39 publications

Interaction between the ADH1B*3 allele and drinking motives on alcohol use among Black college students

Interaction between the ADH1B*3 allele and drinking motives on alcohol use among Black college students

Variations in alcohol-metabolizing enzymes in people of East Indian and African descent from Trinidad and Tobago

Interactions Between Alcohol Metabolism Genes and Religious Involvement in Association With Maximum Drinks and Alcohol Dependence Symptoms

Contact Info

Product

Resources

About

Association of the ADHIB^3* Allele With Alcohol‐Related Phenotypes in Trinidad

Interaction between the ADH1B3* allele and drinking motives on alcohol use among Black college students

Interaction between the ADH1B3* allele and drinking motives on alcohol use among Black college students