Association of the HLA-DR15/HLA-DQ6 haplotype with development of choroidal neovascular lesions in presumed ocular histoplasmosis syndrome

Dabil, Humeyra; Kaplan, Henry J.; Duffy, Brian; Phelan, D.; Mohanakumar, T; Jaramillo, Andrés

doi:10.1016/s0198-8859(03)00175-7

Cited by 17 publications

(10 citation statements)

References 24 publications

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“…20 Like other HLA class II alleles, the presence or absence of HLA DR15 has been implicated in several autoimmune states. [21][22][23][24][25][26][27][28][29][30][31][32][33] The precise relevance of these associations is unknown in the context of BMT.…”

Section: Discussionmentioning

confidence: 99%

Human leukocyte antigen (HLA) DR15 is associated with reduced incidence of acute GVHD in HLA-matched allogeneic transplantation but does not impact chronic GVHD incidence

Battiwalla

Hahn

Radovic

et al. 2006

Blood

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The DR15 allele at the HLA DRB1 locus is a marker for immune-mediated bone marrow failure syndromes. We hypothesized that HLA DR15 plays a role in T-cell interactions with hematopoiesis and investigated the role of HLA DR15 on graftversus-host disease (GVHD) and graftversus-leukemia effects in HLA-matched allogeneic blood or marrow transplantation (BMT) performed for myeloid malignancies. We performed a retrospective analysis of 119 consecutive related and 48 consecutive unrelated allogeneic BMT for myeloid malignancies treated between 1991 and 2005 to investigate the influence of HLA DR15 on overall survival (OS), progression-free survival (PFS), and incidence of grades II to IV acute GVHD. HLA DR15 was determined by either molecular (n ‫؍‬ 108) or serologic (n ‫؍‬ 59) methods. The incidence of HLA DR15 was similar to the general white population (35/167 ‫؍‬ 21%). There were no significant differences in transplantation characteristics between the HLA DR15-positive and -negative groups. There was no significant difference in chronic GVHD, OS, or PFS between the HLA DR15-positive versus-negative groups in any disease or donor relation subgroups. The HLA DR15-positive group experienced a significantly lower incidence of acute GVHD grades II to IV: 23% versus 42% (P ‫؍‬ .041). These results suggest that HLA DR15 reduces the risk of acute GVHD. (Blood.

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Section: Discussionmentioning

confidence: 99%

Human leukocyte antigen (HLA) DR15 is associated with reduced incidence of acute GVHD in HLA-matched allogeneic transplantation but does not impact chronic GVHD incidence

Battiwalla

Hahn

Radovic

et al. 2006

Blood

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“…The patient in their case report provided a blood sample early in the course of infection with negative serological testing [16]. Human leucocyte antigen (HLA) DRw2 and B7 have also been shown to be related to POHS [17]. This may suggest that POHS is on a spectrum of autoimmune conditions, triggered by an infectious organism.…”

Section: Key Pointsmentioning

confidence: 99%

Presumed ocular histoplasmosis

Thuruthumaly

Yee

Rao

2014

Current Opinion in Ophthalmology

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This review highlights the devastating vision loss that may occur in ocular histoplasmosis from the development of an atrophic scar at the fovea or following choroidal neovascularization. Many therapies have been tried with varied amounts of success. Antivascular endothelial growth factor therapy appears to be the gold-standard treatment with the possibility of combined photodynamic therapy in refractory cases.

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“…Dabil et al . [75] reported a significant association between the HLA-DR15/HLA-DQ6 haplotype and development of CNVM in POHS…”

Section: Infective Posterior Uveitismentioning

confidence: 99%

Current approach in the diagnosis and management of posterior uveitis

Sridharan

Ganesh

Biswas

2010

Indian J Ophthalmol

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Posterior uveitic entities are varied entities that are infective or non-infective in etiology. They can affect the adjacent structures such as the retina, vitreous, optic nerve head and retinal blood vessels. Thorough clinical evaluation gives a clue to the diagnosis while ancillary investigations and laboratory tests assist in confirming the diagnosis. Newer evolving techniques in the investigations and management have increased the diagnostic yield. In case of diagnostic dilemma, intraocular fluid evaluation for polymerase chain testing for the genome and antibody testing against the causative agent provide greater diagnostic ability.

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Association of the HLA-DR15/HLA-DQ6 haplotype with development of choroidal neovascular lesions in presumed ocular histoplasmosis syndrome

Cited by 17 publications

References 24 publications

Human leukocyte antigen (HLA) DR15 is associated with reduced incidence of acute GVHD in HLA-matched allogeneic transplantation but does not impact chronic GVHD incidence

Human leukocyte antigen (HLA) DR15 is associated with reduced incidence of acute GVHD in HLA-matched allogeneic transplantation but does not impact chronic GVHD incidence

Presumed ocular histoplasmosis

Current approach in the diagnosis and management of posterior uveitis

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