Association of the DYX1C1 Gene with Chinese Literacy in a Healthy Chinese Population

Waye, Mary Miu Yee; Siu, Cynthia; McBride, Catherine; Ho, Connie Suk‐Han; Wong, Cheuk Wa

doi:10.24251/hicss.2018.355

Proceedings of the 51st Hawaii International Conference on System Sciences 2018

DOI: 10.24251/hicss.2018.355

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Association of the DYX1C1 Gene with Chinese Literacy in a Healthy Chinese Population

Mary Miu Yee Waye

Cynthia Siu

Catherine McBride

et al.

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2022

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Cited by 2 publications

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“…32 Up to date, all previous GWASs on reading ability/disability and reading/dyslexia-related cognitive traits were mainly performed in the Western population, whose genetic backgrounds are different from those of the Chinese population. Though dyslexic candidate genes, such as KIAA0319, DCDC2 and DYX1C1, have been shown to be associated with Chinese dyslexia, [33][34][35][36] no GWAS of reading ability and relative cognitive traits had been conducted in Chinese population until now. In fact, so far there is still no well-recognized definition criterion for Chinese developmental dyslexia.…”

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A genome‐wide association study identifies a new variant associated with word reading fluency in Chinese children

Wang

Zhao

Zhang

et al. 2022

Genes Brain and Behavior

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Reading disability exhibited defects in different cognitive domains, including word reading fluency, word reading accuracy, phonological awareness, rapid automatized naming and morphological awareness. To identify the genetic basis of Chinese reading disability, we conducted a genome‐wide association study (GWAS) of the cognitive traits related to Chinese reading disability in 2284 unrelated Chinese children. Among the traits analyzed in the present GWAS, we detected one genome‐wide significant association (p < 5 × 10−8) on word reading fluency for one SNP on 4p16.2, within EVC genes (rs6446395, p = 7.33 × 10−10). Rs6446395 also showed significant association with Chinese character reading accuracy (p = 2.95 × 10−4), phonological awareness (p = 7.11 × 10−3) and rapid automatized naming (p = 4.71 × 10−3), implying multiple effects of this variant. The eQTL data showed that rs6446395 affected EVC expression in the cerebellum. Gene‐based analyses identified a gene (PRDM10) to be associated with word reading fluency at the genome‐wide level. Our study discovered a new candidate susceptibility variant for reading ability and provided new insights into the genetics of developmental dyslexia in Chinese children.

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confidence: 99%

A genome‐wide association study identifies a new variant associated with word reading fluency in Chinese children

Wang

Zhao

Zhang

et al. 2022

Genes Brain and Behavior

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Contributions of common genetic variants to specific languages and to when a language is learned

Wong

Kang

et al. 2022

Sci Rep

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Research over the past two decades has identified a group of common genetic variants explaining a portion of variance in native language ability. The present study investigates whether the same group of genetic variants are associated with different languages and languages learned at different times in life. We recruited 940 young adults who spoke from childhood Chinese and English as their first (native) (L1) and second (L2) language, respectively, who were learners of a new, third (L3) language. For the variants examined, we found a general decrease of contribution of genes to language functions from native to foreign (L2 and L3) languages, with variance in foreign languages explained largely by non-genetic factors such as musical training and motivation. Furthermore, genetic variants that were found to contribute to traits specific to Chinese and English respectively exerted the strongest effects on L1 and L2. These results seem to speak against the hypothesis of a language- and time-universal genetic core of linguistic functions. Instead, they provide preliminary evidence that genetic contribution to language may depend at least partly on the intricate language-specific features. Future research including a larger sample size, more languages and more genetic variants is required to further explore these hypotheses.

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Association of the DYX1C1 Gene with Chinese Literacy in a Healthy Chinese Population

Cited by 2 publications

References 34 publications

A genome‐wide association study identifies a new variant associated with word reading fluency in Chinese children

A genome‐wide association study identifies a new variant associated with word reading fluency in Chinese children

Contributions of common genetic variants to specific languages and to when a language is learned

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