Association of the CYP17 MSP AI (T-34C) and CYP19 codon 39 (Trp/Arg) polymorphisms with susceptibility to acne vulgaris

Abstract

The aim of this study was to detect the association of the cytochrome P450 (CYP) 17 T-34C and CYP19 T<C polymorphisms with the risk of acne vulgaris (AV). The study enrolled 198 patients with AV (mild, moderate and severe) and 195 unrelated age-matched healthy controls from western Iran who had Kurdish ethnic background. The presence of the CYP17 TC genotype significantly increased the risk of mild, moderate and severe AV by 2.68, 2.28 and 2.94 times, respectively, while the presence of the CYP19 TC genotype significantly elevated the risk of overall AV and mild AV by 2.1 and 3.2 times, respectively. There was a synergy between the CYP 17 TC and CYP19 TT genotypes, which increased the risk of AV by 2.45-fold (P < 0.001). To our knowledge, this is the first study showing that the CYP17 T-34C and CYP19 T<C variants and their synergy are associated with susceptibility to AV in an Iranian population.

Association of cytochrome P-45017 (T-34C) polymorphism and the risk of acne vulgaris: a meta-analysis

“…Some of the characteristics of the four studies included in the meta-analysis are shown in table 1. Two studies [8,13] were reported from Chinese, one [6] from Iranian, and one [14] from Polish populations. In all studies [6,8,13,14], the genotype distribution of the polymorphism in controls corresponded with Hardy-Weinberg equilibrium (HWE).…”

“…In the overall analysis, there was heterogeneity in the allele, the heterozygote, and the dominant, models. There was no acne risk related to CYP17 (T-34C) in any of the genetic models in Caucasian ethnicity [6,14], whereas in Asian ethnicity [8,13] there was acne risk related to CYP17 (T-34C) without heterogeneity in analyses of C vs. T, CC vs. TT, CC + TC vs. TT, and CC vs. TT + TC in acne patients compared to the healthy controls; OR was 1.34 (95% CI: 1.05-1.72), 1.76 (95% CI: 1.08-2.87), 1.42 (95% CI: 0.95-2.11), and 1.52 (95% CI: 1.02-2.27), respectively.…”

“…W piśmiennictwie opisywano obecność polimorfizmu pojedynczego nukleotydu (SNP) T>C (T-34C) w nukleotydzie 27 promotora genu CYP17, wskazując na jego powiązanie z ryzykiem rozwoju raka piersi [11,12]. Oprócz roli tego genu w trądziku [6,8,13,14] badano także zależność między CYP17 a zespołem Downa i chorobą Alzheimera [15] oraz rakiem gruczołu krokowego [16].…”

“…Wybraną charakterystykę 4 badań uwzględnionych w metaanalizie przedstawiono w tabeli 1. Dwa badania [8,13] zostały przeprowadzone w populacji chińskiej, jedno [6] w irańskiej i jedno [14] w polskiej. We wszystkich badaniach [6,8,13,14] rozkład genotypowy polimorfizmu w grupach kontrolnych był zgodny z równowagą Hardy'ego-Weinberga (HWE).…”

The Association Between Polycystic Ovary Syndrome and Its Dermatological Manifestations

“…Thus, in PCOS, where androgen is on a higher level, there will be IGFR activity present and, consequently, high CYP19 and dysfunctioning CYP17 levels are recorded [33,34]. In a study among 198 Iranian patients diagnosed with acne vulgaris conducted to shed some light on the association between acne vulgaris and two genotypes of CYP 450 (CYP 17 and CYP 19), it was proved that both genotypes are connected to the occurrence of acne vulgaris [35].…”