Association of the cyclooxygenase-2 1759A allele with migraine in Chinese Han individuals

Abstract

Cyclooxygenase-2 (COX-2) is known to be involved in the pathogenesis of migraine, and some polymorphisms are known to affect the expression of COX-2. This retrospective casecontrol study aimed to explore the associations between the-765 G>C (rs20417),-1759 G>A (rs3218625), and-8473 C>T (rs5275) COX-2 polymorphisms and migraine in Chinese Han individuals. One hundred and ten unrelated Han Chinese patients with migraine and 108 healthy controls were recruited between 03/2014 and 08/2016 at the First Affiliated Hospital of Nanjing Medical University and the First People's Hospital of Lianyungang City. The genotypes of all polymorphisms in controls followed the Hardy-Weinberg equilibrium (P = 0.215, P = 0.884, and P = 0.689). There were differences in the genotype and allele distributions of the COX-2-1759G>A (Gly587Arg) polymorphism between the migraine and control groups (P = 0.038 and P = 0.040, respectively). Compared with the COX-2-1759AG genotype, GG genotype carriers had an increased risk of migraine (odds ratio (OR) = 8.720, 95% confidence interval (CI): 1.072-70.960, P = 0.038). The frequency of the COX-2-1759A allele in patients with migraine was significantly lower than the controls (OR = 0.119, 95%CI: 0.015-0.957, P = 0.040). Adjusted age and sex, a statistical difference was found in the dominant model of COX-2-1759 G>A (OR = 0.118, 95% CI 0.014 to 0.962, P = 0.046). No significant difference was detected regarding the-765G>C and-8473T>C polymorphisms between the two groups. The COX-2 1759A allele might be involved in the development of migraine in Chinese Han individuals, but this will have to be confirmed in large-scale studies.

COX-2-8473 T>C gene variant (rs5275) is associated with depression and nausea in migraineurs by increasing inflammation through MyD88/MAP2K3/COX-2

“…4B). It has been reported that there is no signi cant relationship between migraine and this polymorphism in that area (Guan et al, 2020). Considering these results, we carried out this study among Iranian migraineurs to examine the associations of migraine, depression, and nausea with the COX-2-8473T > C (rs5275) polymorphism.…”