Association of the COMT and DRD2 Genes with the Ability of Schizophrenia Patients to Understand the Mental State of Other People

Алфимова, М. В.; Golimbet, V. E.; Коровайцева, Г. И.; Aksenova, E. A.; Лежейко, Т. В.; Абрамова, Л. И.; Kolesina, N.Yu.; Ануа, И. М.; Савельева, Т. М.

doi:10.1007/s11055-014-0034-z

Cited by 5 publications

(3 citation statements)

References 44 publications

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“…Гены дофаминергической системы, изучавшиеся при нейрокогнитивном дефиците у больных шизофренией, включают гены, кодирующие катехол-О-метилтрансферазу (COMT), дофаминовый транспортер (DAT), норадреналиновый транспортер (NET), дофаминовые рецепторы D1 (DRD1), D2 (DRD2), D3 (DRD3), D4 (DRD4), D5 (DRD5), везикулярный моноаминовый транспортер 2 (SLC18A2), анкириновый повтор и киназный домен, содержащий 1 (ANKK1), дофамин бета-гидроксилазу (DBH), протеин фосфатазу 1, регуляторную (ингибиторную) субъединицу 1В (PPP1R1B) [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24].…”

Section: гены нейротрансмиттерных системunclassified

“…Метаанализ 12 работ о влиянии COMT Val158Met на исполнительские функции выявил значительную ассоциацию между генотипом Val/Val и ухудшением когнитивной деятельности у здоровых людей по сравнению с генотипом Met/Met, которая не прослеживается у больных шизофренией [13]. В одном из исследований [21] было отмечено ухудшение когнитивной деятельности у женщин -носителей аллеля Met не только при расстройствах шизофренического спектра, но и у здоровых. А. Loch и соавт.…”

Section: гены нейротрансмиттерных системunclassified

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A new look at the genetics of neurocognitive deficits in schizophrenia

Fedorenko

Иванова

2020

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Резюме В обзоре приведены современные данные литературы, касающиеся генетических исследований нейрокогнитивного дефицита при шизофрении. Рассмотрены гены нейротрансмиттерных систем (дофаминергическая, глутаматергическая и серотонинергическая); гены, проанализированные в полногеномных ассоциативных исследованиях (GWAS), а также другие генетические факторы, связанные с механизмами развития шизофрении и нейрокогнитивных расстройств.

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Section: гены нейротрансмиттерных системunclassified

A new look at the genetics of neurocognitive deficits in schizophrenia

Fedorenko

Иванова

2020

Z. nevrol. psikhiatr. im. S.S. Korsakova

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“…The role of dopamine transmission in impairments in the ToM in schizophrenia has been explored between genes encoding dopamine receptor D2 (DRD2) and the enzyme of catecholamine metabolism, catechol-Omethyltransferase (COMT). Alfimova et al [107] investigated the association between ToM, as measured using the second-order false beliefs task, and DRD2 receptor and Several studies have reported that the SNP rs1344706 of the zinc-finger protein gene (ZNF804A) is strongly implicated in schizophrenia [108][109][110].…”

Section: Genetic Contribution Of Theory Of Mind Deficitsmentioning

confidence: 99%

Theory of Mind in the Early Course of Schizophrenia

Vyas

et al. 2017

CPSR

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Theory of mind deficit is a core feature of schizophrenia and is considered a vulnerability marker of the disorder. The majority of studies measuring theory of mind in schizophrenia involve multiple-episode or chronic schizophrenia patients, and therefore it is important to delineate whether these deficits occur before or following illness-onset by assessing high-risk subjects (clinical high risk and ultra-high risk), early-onset psychosis, and first-degree relatives. We address the question of whether theory of mind impairment is specific or a facet of general cognitive impairment in these clinical populations, and incorporate genetic and neuroimaging studies on theory of mind. The review provides a succinct evaluation of the literature, discusses current limitations and proposes future directions.

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Investigating the association between common DRD2/ANKK1 genetic polymorphisms and schizophrenia: a meta-analysis

Habibzadeh

Nemati

Dastsooz

et al. 2021

J Genet

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Genetic factors play an important role in the pathogenesis of schizophrenia. Dysregulations in the dopaminergic system have long been known to play an influential role in the development of this disorder. Although a large number of studies have investigated the association between genetic polymorphisms in the genes involved in this system and the risk of schizophrenia, the results have been inconsistent. In this meta-analysis, we searched for publications in Ovid Medline, Embase, Web of Science (science citation index expanded), and PsycNET for articles published until January 2020. We identified case-control studies investigating the association between four common genetic polymorphisms (rs6277, rs1799732, rs1800497, and rs1801028) and the risk of schizophrenia. The studies were subsequently selected according to the predefined inclusion and exclusion criteria. The data extraction was conducted according to the PRISMA guidelines. We also assessed the quality of the studies and investigated publication bias using funnel plot and Egger's regression test. The association analysis was conducted in allelic, dominant, and recessive genetic models. Subsequently, bioinformatics analysis of the effect of the polymorphisms found to be significantly associated with schizophrenia on protein stability, posttranslational modifications, and 3D protein structure was conducted. This meta-analysis showed that Taq1A (allelic model: OR, 0.856, 95% CI, 0.734-0.998) has a protective effect against the development of schizophrenia. Further, it was found that this variant may decrease ANKK1 protein stability. Further, this polymorphism was found to lead to the gain of modifications sites for ubiquitination (Ubi. score = -1.894) and methylation (Meth. score = -0.834). Several genetic factors contribute to the susceptibility of schizophrenia. The updated knowledge emerging from this meta-analysis showing the protective effect of rs1800497 polymorphism (Taq1A) can shed light on the role of Taq1A polymorphism in the susceptibility to schizophrenia and also pave way for further functional studies investigating the role of ANKK1 protein in the pathogenesis of schizophrenia.

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Association of the COMT and DRD2 Genes with the Ability of Schizophrenia Patients to Understand the Mental State of Other People

Cited by 5 publications

References 44 publications

A new look at the genetics of neurocognitive deficits in schizophrenia

A new look at the genetics of neurocognitive deficits in schizophrenia

Theory of Mind in the Early Course of Schizophrenia

Investigating the association between common DRD2/ANKK1 genetic polymorphisms and schizophrenia: a meta-analysis

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