Association of the cholesteryl ester transfer protein Taq1 B2B2 genotype with higher high-density lipoprotein cholesterol concentrations and lower risk of coronary artery disease in a Tunisian population

Rejeb, Jaleleddine Ben; Omezzine, Asma; Raîs, L.; Naffeti, Ilyes; Kchok, Kaouther; Belkahla, Radhia; HadjMbarek, Ibtihel Bel; Rejeb, N.; Nabli, Naoufel; Boujelbene, Amira; Abdelaziz, Ahmed Ben; Boughzala, E.; Bouslama, Ali

doi:10.1016/j.acvd.2008.09.013

Cited by 19 publications

(13 citation statements)

References 33 publications

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“…The study selection process is detailed in Figure 1 . Through a comprehensive retrieval and evaluation, 45 studies from 44 papers with 20,866 cases and 21,298 controls met the inclusion criteria to assess the association between the CETP TaqIB polymorphism and the composite ischemic CVD [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ]. The selected study characteristics and data are listed in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations: A Meta-Analysis

Guo

Yao

Ding

et al. 2016

IJERPH

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Background: Previous studies have evaluated the associations between the cholesteryl ester transfer protein (CETP) TaqIB polymorphism (rs708272), the risk of developing composite ischemic cardiovascular disease (CVD) and the concentration of high-density lipoprotein cholesterol (HDL-C), but results remain controversial. The objective of this study was to investigate whether a relationship exists between these factors. Methods: We conducted a meta-analysis of available studies to clarify the associations of the CETP TaqIB polymorphism with HDL-C concentration and the composite ischemic CVD risk in both Asians and Caucasians. All statistical analyses were done with Stata 12.0. Results: Through utilization of the Cochrane Library, Embase, PubMed, Web of Science, Springer, China Science and Technology Journal Database, China National Knowledge Infrastructure, Google Scholar, and Baidu Library, a total of 45 studies from 44 papers with 20,866 cases and 21,298 controls were combined showing a significant association between the CETP TaqIB variant and composite ischemic CVD risk. Carriers of allele TaqIB-B1 were found to have a higher risk of composite ischemic CVD than non-carriers: OR = 1.15, 95% CI = 1.09–1.21, p < 0.001. Meanwhile, 28 studies with 23,959 subjects were included in the association between the CETP TaqIB polymorphism and the concentration of HDL-C. Results suggested that carriers of the B1B1 genotype had lower concentrations of HDL-C than those of the B2B2 genotype: SMD = 0.50, 95% CI = 0.36–0.65, p < 0.001. Conclusions: The synthesis of available evidence demonstrates that the CETP TaqIB polymorphism protects against composite ischemic CVD risk and is associated with a higher HDL-C concentration in both Asians and Caucasians.

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Section: Resultsmentioning

confidence: 99%

Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations: A Meta-Analysis

Guo

Yao

Ding

et al. 2016

IJERPH

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“…The clinical characteristics of the eligible studies are summarized in Additional file 1 : Table S1. All the eligible studies were published between 1991 and 2012.There were 20 studies performed in Asian subjects [ 11 , 38 , 47 , 51 , 57 , 58 , 60 , 63 , 65 , 66 ], 26 in Caucasian subjects [ 17 , 20 - 22 , 36 , 37 , 40 - 46 , 49 , 50 , 52 - 56 , 59 , 61 , 62 , 64 , 67 ] and one mixed- population study [ 48 ]. In consideration of the study design, 6 studies were prospective [ 20 , 40 , 43 , 45 , 49 ] and the remaining 41 studies were retrospective [ 11 , 17 , 21 , 22 , 36 - 38 , 41 , 42 , 44 , 46 - 48 , 50 - 67 ].…”

Section: Resultsmentioning

confidence: 99%

“…In addition,11 of the 47 studies were P-B [ 20 - 22 , 36 , 37 , 40 , 43 , 46 , 49 , 54 ] and the remaining studies were H-B [ 11 , 17 , 38 , 39 , 41 , 42 , 44 , 45 , 47 , 48 , 50 - 53 , 55 - 66 ]. CAD was regarded as the main outcome in most of the studies [ 11 , 17 , 21 , 22 , 36 - 40 , 42 , 44 , 45 , 47 , 49 - 51 , 53 , 55 - 61 , 64 - 66 ], except 8 studies analyzed MI [ 20 , 43 , 46 , 48 , 52 , 54 , 62 , 63 ] and 2 studies analyzed ACS [ 41 ] as the endpoint. A significant departure from HWE was found in 7 studies [ 21 , 39 , 48 , 52 , 63 ].…”

Section: Resultsmentioning

confidence: 99%

Association of cholesteryl ester transfer protein (CETP) gene polymorphism, high density lipoprotein cholesterol and risk of coronary artery disease: a meta-analysis using a Mendelian randomization approach

Lou

Qiu

et al. 2014

BMC Med Genet

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BackgroundRecent randomized controlled trials have challenged the concept that increased high density lipoprotein cholesterol (HDL-C) levels are associated with coronary artery disease (CAD) risk reduction. The causal role of HDL-C in the development of atherosclerosis remains unclear. To increase precision and to minimize residual confounding, we exploited the cholesteryl ester transfer protein (CETP)-TaqIB polymorphism as an instrument based on Mendelian randomization.MethodsThe Mendelian randomization analysis was performed by two steps. First, we conducted a meta-analysis of 47 studies, including 23,928 cases and 27,068 controls, to quantify the relationship between the TaqIB polymorphism and the CAD risk. Next, the association between the TaqIB polymorphism and HDL-C was assessed among 5,929 Caucasians. We further employed Mendelian randomization to evaluate the causal effect of HDL-C on CAD based on the findings from the meta-analysis.ResultsThe overall comparison of the B2 allele with the B1 allele yielded a significant risk reduction of CAD (P < 0.0001; OR = 0.88; 95% CI: 0.84–0.92) with substantial between-study heterogeneity (I2 = 55.2%; Pheterogeneity <0.0001). The result was not materially changed after excluding the Hardy-Weinberg Equilibrium (HWE)-violation studies. Compared with B1B1 homozygotes, Caucasian carriers of the B2 allele had a 0.25 mmol/L increase in HDL-C level (95% CI: 0.20–0.31; P <0.0001; I2 = 0; Pheterogeneity =0.87). However, a 1 standard deviation (SD) elevation in HDL-C levels due to the TaqIB polymorphism, was marginal associated with CAD risk (OR =0.79; 95% CI: 0.54–1.03; P =0.08).ConclusionsTaken together, our results lend support to the concept that increased HDL-C cannot be translated into a reduction in CAD risk.Electronic supplementary materialThe online version of this article (doi:10.1186/s12881-014-0118-1) contains supplementary material, which is available to authorized users.

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“…Atherogenic dyslipidemia is characterized by abnormal levels of triglycerides, low- and high-density lipoprotein (LDL-C and HDL-C) [ 8 – 10 ]. Functionally relevant mutations in the dyslipidemia-related genes and gene encoding enzymes involved in the reverse cholesterol transport system have been reported to be associated with high-density lipoprotein-cholesterol (HDL-C) levels [ 11 – 13 ]. Epidemiological and clinical studies have demonstrated a contradictory association between HDL-C concentrations and cardiovascular risk [ 10 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

The impact of common polymorphisms in CETP and ABCA1 genes with the risk of coronary artery disease in Saudi Arabians

et al. 2016

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BackgroundCoronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Many genetic and environmental risk factors including atherogenic dyslipidemia contribute towards the development of CAD. Functionally relevant mutations in the dyslipidemia-related genes and enzymes involved in the reverse cholesterol transport system are associated with CAD and contribute to increased susceptibility of myocardial infarction (MI).MethodBlood samples from 990 angiographically confirmed Saudi CAD patients with at least one event of myocardial infarction were collected between 2012 and 2014. A total of 618 Saudi controls with no history or family history of CAD participated in the study. Four polymorphisms, rs2230806, rs2066715 (ABCA1), rs5882, and rs708272 (CETP), were genotyped using TaqMan Assay.ResultsCETP rs5882 (OR = 1.45, P < 0.005) and ABCA1 rs2230806 (OR = 1.42, P = 0.017) polymorphisms were associated with increased risk of CAD. However, rs708272 polymorphism showed protective effect (B1 vs. B2: OR = 0.80, P = 0.003 and B2B2 vs. B1B1: OR = 0.68, P = 0.012) while the ABCA1 variant rs2066715 was not associated.ConclusionThis study is the first to report the association of these polymorphisms with CAD in the population of the Eastern Province of Saudi Arabia. The rs5882 polymorphism (CETP) showed a significant association and therefore could be a promising marker for CAD risk estimation while the rs708272 polymorphism had a protective effect from CAD.

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Association of the cholesteryl ester transfer protein Taq1 B2B2 genotype with higher high-density lipoprotein cholesterol concentrations and lower risk of coronary artery disease in a Tunisian population

Abstract: Our data suggest that the B2 allele is associated with higher concentrations of HDL-C, which confer a protective effect with regard to coronary atherosclerosis. This effect seems to be more significant in men than in women and in nonsmokers than in smokers.

Cited by 19 publications

References 33 publications

Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations: A Meta-Analysis

Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations: A Meta-Analysis

Association of cholesteryl ester transfer protein (CETP) gene polymorphism, high density lipoprotein cholesterol and risk of coronary artery disease: a meta-analysis using a Mendelian randomization approach

The impact of common polymorphisms in CETP and ABCA1 genes with the risk of coronary artery disease in Saudi Arabians

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