Association of the Chimpanzee Coryza Agent with Acute Respiratory Disease in Children

Beem, Marc O.; Wright, Francis H.; Hamre, Dorothy; Egerer, Rosalie; Oehme, Mafalda

doi:10.1056/nejm196009152631101

Cited by 133 publications

(27 citation statements)

References 3 publications

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“…In the present study many of the convalescent sera were collected in the second to third week of illness before the children left hospital; this may explain our failure to detect a rise in CF antibody to RS virus in five children from whom RS virus was isolated. However, as all these five were under 4 months of age this might support the finding of previous workers (Beem et al 1960;Chanock et al 1961;Gardner, Elderkin & Wall, 1964) that a CF antibody response to RS virus infection is rarely detected during the first few months of life. In our earlier study differences in neutralizing antibody titres had been detected by the use of a strain of RS virus isolated locally but we could not repeat this finding with strains isolated during the present study.…”

Section: Discussionsupporting

confidence: 89%

A comparative virological study of children in hospital with respiratory and diarrhoeal illnesses

Stott

Bell

Eadie

et al. 1967

J. Hyg.

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Between October 1963 and April 1965, 113 children with respiratory disease and 113 children with diarrhoeal disease were matched for age and time of entry into hospital and studied by virus isolation and serological techniques.Infections with respiratory syncytial (RS) virus, parainfluenza virus and herpes simplex virus respectively were found in 29, 11 and 12 children in the respiratory illness group but in only 1, 2 and 4 children in the diarrhoeal group. Rhinoviruses were isolated from 10 children in each group and in seven cases were associated with lower respiratory disease. Adenovirus infections were found in nine children with respiratory disease and eight with diarrhoea. Of the 40 enteroviruses isolated 16 were associated with respiratory disease and 24 with diarrhoea.A poor or delayed serological response in children under 4 months with RS virus infection was observed. Addition of unheated rabbit serum increased the sensitivity of the neutralization test with RS virus.These findings indicate that respiratory syncytial and parainfluenza virus infections were clearly associated with respiratory illness but the pathogenic role of the other viruses was not clear.

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Section: Discussionsupporting

confidence: 89%

A comparative virological study of children in hospital with respiratory and diarrhoeal illnesses

Stott

Bell

Eadie

et al. 1967

J. Hyg.

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“…5,8 HRSV was first isolated in 1956 from a colony of chimpanzees that presented various symptoms, including coughing, sneezing, and purulent nasal discharge. 9,10 The illness quickly spread from sick chimpanzees to other monkeys, indicating the presence of a highly contagious pathogen that was originally denominated the chimpanzee coryza agent. 10 In 1957, Chanock and Finberg isolated a similar agent from throat swab samples of infants with a severe respiratory disease, 11,12 which was found to be identical to the one reported by Blount et al in chimpanzees.…”

Section: Introductionmentioning

confidence: 99%

Aberrant T cell immunity triggered by human Respiratory Syncytial Virus and human Metapneumovirus infection

et al. 2016

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Human Respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are the two major etiological viral agents of lower respiratory tract diseases, affecting mainly infants, young children and the elderly. Although the infection of both viruses trigger an antiviral immune response that mediate viral clearance and disease resolution in immunocompetent individuals, the promotion of long-term immunity appears to be deficient and reinfection are common throughout life. A possible explanation for this phenomenon is that hRSV and hMPV, can induce aberrant T cell responses, which leads to exacerbated lung inflammation and poor T and B cell memory immunity. The modulation of immune response exerted by both viruses include different strategies such as, impairment of immunological synapse mediated by viral proteins or soluble factors, and the induction of pro-inflammatory cytokines by epithelial cells, among others. All these viral strategies contribute to the alteration of the adaptive immunity in order to increase the susceptibility to reinfections.In this review, we discuss current research related to the mechanisms underlying the impairment of T and B cell immune responses induced by hRSV and hMPV infection. In addition, we described the role each virulence factor involved in immune modulation caused by these viruses.

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“…Although it is well known that specimens for RS isolation should preferably not be frozen (Beem et al, 1960) several workers have found that fairly good virus recovery can be achieved if the specimen is snap-frozen and held at low temperature in a protective medium wambling, 1964;Suto et al, 1965;Law and Hull, 1968), but the results of direct comparisons have not been reported before. Our results (table 11) confirm the observations of Beem et al (1960).…”

Section: Resultsmentioning

confidence: 99%

Bovine-Testis Cells for Routine Isolation of Respiratory Syncytial Virus From Infants

Caul

Jacobs

Clarke

1974

Journal of Medical Microbiology

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Association of the Chimpanzee Coryza Agent with Acute Respiratory Disease in Children

Cited by 133 publications

References 3 publications

A comparative virological study of children in hospital with respiratory and diarrhoeal illnesses

A comparative virological study of children in hospital with respiratory and diarrhoeal illnesses

Aberrant T cell immunity triggered by human Respiratory Syncytial Virus and human Metapneumovirus infection

Bovine-Testis Cells for Routine Isolation of Respiratory Syncytial Virus From Infants

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