Association of the Charlson Comorbidity Index with Renal Outcome and All-Cause Mortality in Antineutrophil Cytoplasmatic Antibody-Associated Vasculitis

Abstract

The aim of this study is to determine the effect of comorbidity assessed by the Charlson comorbidity index (CCI) at the time of diagnosis on the outcome of antineutrophil cytoplasmatic antibody (ANCA) associated vasculitis (AAV).This is a longitudinal observational study of 30 consecutive patients with AAV who were diagnosed and followed from January 1996 to December 2011. The degree of comorbidity at diagnosis and last visit was scored according to the age-adjusted Charlson comorbidity index (CCI (a)). The post hoc analysis of increment in CCI during the study period and its predictive value for patient and renal survival were analyzed.Thirty patients with AAV were included in this study. A higher CCI (a) at diagnosis was positively correlated with higher activity score of AAV (P = 0.016), a CCI (a) >5, and with an increased risk for mortality (odds ratio 12; confidence interval 1.8–79.68, P = 0.014). The mean increment (Δ) of CCI (a) during the study period was 1.26 ± 2.03 (6–5). Correlation was found between lower Δ CCI (a) and chronic kidney disease (P = 0.036) and mortality (P = 0.002).Comorbidity at the time of diagnosis of AAV is associated with reduced patient and renal survival. We suggest including the CCI score in the assessment of patients with AAV at diagnosis and at disease relapse.

Early predictors of one-year mortality in patients over 65 presenting with ANCA-associated renal vasculitis: a retrospective, multicentre study

“…Our results also suggest that other patient-specific factors (such as the baseline ECOG Performance Status and the CCI) contribute to reduced tolerance of immunosuppression. Some previous studies have also found that comorbidity is correlated with lower patient and renal survival rates [ 24 , 25 ].…”

Adaption and validation of Nijmegen continuity questionnaire to recognize the influencing factors of continuity of care for hypertensive patients in China

“…Based on the guideline of prevention and treatment of hypertension in primary care, primary care providers must carry out family visit at least once every 3 months, so the frequency of family visit was set as dichotomous variable with the option of less than 4 times per year or more. Patients’ comorbidities were tested by Charlson comorbidity index [32], which was broadly used in experimental and clinical researches.…”

Clinical predictors of outcome in patients with infective endocarditis receiving outpatient parenteral antibiotic therapy (OPAT)

“…11 Chronic kidney disease was based upon an estimated glomerular filtration rate of <60 ml/min/1.73 m 2 . 12 Drugresistant organisms included methicillin-resistant Staphylococcus aureus and penicillinresistant streptococci. The study was approved by the Trust's clinical effectiveness unit.…”