Association of the BDNF Val66Met variation with obesity in women

Beckers, Sigri; Peeters, Armand V.; Zegers, Doreen; Mertens, Ilse; Gaal, Luc Van; Hul, Wim Van

doi:10.1016/j.ymgme.2008.06.008

Cited by 62 publications

(51 citation statements)

References 17 publications

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“…Our finding obtained in young participants is in line with data showing over-expression of the Met allele in a large cohort of obese adult women from Belgium (Beckers et al, 2008), but differs from the results obtained in carriers of the Met/Met genotype in obese populations of British women (Shugart et al, 2009), and healthy Caucasian adults without significant medical or psychiatric history (Gunstad et al, 2006) which had lower mean BMI than subjects with Met/Val or Val/Val genotypes. The divergent results might be attributed to different study designs, different study groups (obese versus healthy), or the population genetic differences in BDNF Val66Met (Petryshen et al, 2010), that may lead to the conflicting association results between studies, evaluating the role of BDNF Val66Met in various psychiatric disorders and altered behaviors.…”

Section: Discussionsupporting

confidence: 82%

“…obesity was significantly associated with one or two Met alleles of the BDNF genotype (data not shown). Gender has been proposed to affect the association between BDNF Val66Met and BMI (Arija et al, 2010;Beckers et al, 2008), however multiple regression analysis in our study excluded the possible effect of gender, at least in our sample, presumably due to the fact that most of them were pre-pubertal and did not reach neurodevelopmental maturity, as emphasized in previous studies (Arija et al, 2010). Since we detected significant differences in the distribution of the BDNF Val66Met variants between Caucasian (Croatian) and Asian (South Korean) healthy adult subjects (Pivac et al, 2009), and there is substantial global population diversity in the BDNF Val66Met polymorphism (Petryshen et al, 2010), to exclude population genetic differences in BDNF, we selected only Caucasian children and adolescents of Croatian origin.…”

Section: Discussionmentioning

confidence: 69%

“…Most of the studies evaluated the role of BDNF Val66Met in eating disorders, and found either a significant association (Akkermann et al, 2011;Gratacos et al, 2007), or no association (Arija et al, 2010;Friedel et al, 2005) between the Met allele and eating disorders. The ethnic (Pivac et al, 2009), as well as population-related genetic differences (Petryshen et al, 2010) might explain the conflicting association results showing either that BDNF Val66Met Met/Met genotype was more frequently found in adult women with higher (Beckers et al, 2008) or with lower (Shugart et al, 2009) BMI. Therefore, the aim of this study was to determine the association between BDNF Val66Met variants and obesity in healthy Caucasian children and adolescents of the same ethnic background of Croatian origin, subdivided according to the BMI measures.…”

Section: Introductionmentioning

confidence: 99%

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Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents

Škledar¹,

Nikolac

Dodig-Ćurković

et al. 2012

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents

Škledar¹,

Nikolac

Dodig-Ćurković

et al. 2012

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…Genetic factors are increasingly recognized 51 Obesity in serotonin transporter knockout mice N Üc -eyler et al susceptibility for the development of obesity also in humans. 54 Furthermore, insight into the role of protective factors as in female 5-HTT ko mice may be relevant to the prevention and treatment of obesity in humans.…”

Section: Discussionmentioning

confidence: 99%

Lack of the serotonin transporter in mice reduces locomotor activity and leads to gender-dependent late onset obesity

et al. 2010

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Objective: Mice deficient of the serotonin transporter (5-HTT ko) mice have a reduced brain serotonin content and develop lateonset obesity. To elucidate the pathophysiology of this obesity, we analyzed the expression of the interrelated weight-regulatory molecules: brain-derived neurotrophic factor (BDNF) and leptin receptor (LR) in brain areas associated with nutrition and activity. Research Design and Methods: We investigated feeding behavior, physical activity and metabolic parameters of 5-HTT ko and wild-type mice and measured the expression of BDNF and LR in brain areas associated with nutrition and activity using quantitative real-time PCR. The influence of age, gender and fasting was analyzed. Results: Male 5-HTT ko mice developed obesity without hyperphagia from the age of 5 months. Physical activity was reduced in old male, but not old female, 5-HTT ko mice. The BDNF gene expression in frontal cortex was elevated in young, but reduced in old 5-HTT ko mice. Fasting failed to increase the BDNF gene expression in frontal cortex of young 5 HTT ko mice and in the hypothalamus in old 5-HTT ko mice. The fasting-induced hypothalamic increase of LR was absent in both young and old 5-HTT ko mice. Conclusions: We propose that low brain serotonin level due to the 5-HTT ko genotype leads to reduced physical activity and low BDNF, which together with the lack of fasting-induced hypothalamic BDNF and LR production results in late-onset obesity. Although lack of the 5-HTT is a genetic vulnerability factor for obesity, female gender is protective.

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“…In context of obesity, many studies show the influence of BDNF on food intake, feeding behavior, body mass index (BMI) and the pathogenesis of eating disorders [12][13][14][15][16][17][18]. However, the exact mechanism by which BDNF affects appetite, and hence contribute to development of obesity is still unknown [19].…”

Section: Introductionmentioning

confidence: 99%

Brain-Derived Neurotrophic Factor Val66Met Polymorphism in Contex of Executive Functions and Working Memory in Obese Patients

Bieliaski¹,

Lesiewska²,

Jaracz³

et al. 2018

Neuropsychiatry

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Neurothrophins are crucial in the regulation of many processes, such as nerve cells development and neuroplasticity and brain-derived neurothrophic factor (BDNF) is the major one. Researchers still scrutinize the role of BDNF Val66Met polymorphism in eating disorders and cognition, however, literature present inconsistent findings regarding this topic. Most of all, the exact mechanism of how exactly BDNF influences cognitive functioning in obesity is unknown. In our study, we try to elucidate the association of BDNF Val66Met polymorphism with executive functions and working memory on large obese population. 375 obese patients underwent biometric analyses and neuropsychological assessment. The Wisconsin Card Sorting Test (WCST) was used to assess cognitive functions. Genetic polymorphism in BDNF was evaluated in peripheral blood samples.Results indicated that both BDNF Val66Met polymorphism and gender showed significant correlations with BMI, WCST_P and WCST_CLR. Females showed higher BMI values than men,, however males scored higher in WSCT_P and WSCT_CLR. Val/Val carriers presented worse results of WCST and BMI. Kendall's partial rank correlation tests determined that both genotype and BMI showed significant correlations with WCST_CLR, WCST_CC and WCST_1st, in which BMI correlation was stronger. Analysis of mild and morbid obesity showed, that severe obese younger subjects presented worse WCST_P, WCST_NP, and WCST_CLR. Significant interaction effects for WCST parameters were found for gender, age, BMI and BDNF Val66Met. Importantly, in this study none Met/Met carriers were observed.The Val66Met BDNF polymorphism indirectly influenced the poorer cognitive functioning observed in the obese subpopulation with Val/Val genotype, rather than Val/Met genotype. A higher BMI was associated with the Val allele, suggesting that obesity may have deteriorated the activity of the prefrontal cortex. According to results, BDNF Val66Met polymorphism seems to contribute to greater obesity in our study. It is greater BMI, rather than genotype, which caused worse executive functioning and working memory. KeywordsVal66Met BDNF, Neurothrophins, Obesity Neuropsychiatry (London) (2018) 8(1) 112Research Maciej Bieliński the worse scores in WCST, and how BDNF Val66Met influences the severity of obesity. Materials and Methods ParticipantsA total of 375 adult Caucasian patients of Polish nationality were enrolled in this study, including 233 women and 142 men, after excluding secondary reasons of obesity. The mean age of all participants was 54 (range, 20-76) years old; the mean age for women was 52 (20-75) years old, and for men 56 (42-67) years old. The exclusion criteria were individuals with a severe somatic or psychiatric disorder included in the Diagnostic

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Association of the BDNF Val66Met variation with obesity in women

Cited by 62 publications

References 17 publications

Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents

Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents

Lack of the serotonin transporter in mice reduces locomotor activity and leads to gender-dependent late onset obesity

Brain-Derived Neurotrophic Factor Val66Met Polymorphism in Contex of Executive Functions and Working Memory in Obese Patients

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