Association of the Ban 1 dimorphic site at the human cytosolic phospholipase A2 gene with schizophrenia

Peet, Malcolm; Ramchand, C.N.; Lee, J; Telang, S.D.; Vankar, Ganpat; Shah, Saurabh; Wei, Jun

doi:10.1097/00041444-199800830-00010

Cited by 50 publications

(26 citation statements)

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“…The fact that certain polyunsaturated fatty acids, particularly arachidonic acid and docosahexaneoic acid, are significantly depleted in membrane phospholipids from patients with schizophrenia, and the recent reports of significant reductions in positive symptoms in patients after essential fatty acids supplementation (Peet, 1999), makes cPLA2 gene an interesting candidate gene in schizophrenia genetics. To date, two polymorphisms at the cPLA2 locus have been reported to be associated with schizophrenia Peet et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Association studies of cytosolic phospholipase A2 polymorphisms and schizophrenia among two independent family-based samples

Chowdari

Brandstaetter²,

Semwal³

et al. 2001

Psychiatric Genetics

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Section: Discussionmentioning

confidence: 99%

Association studies of cytosolic phospholipase A2 polymorphisms and schizophrenia among two independent family-based samples

Chowdari

Brandstaetter²,

Semwal³

et al. 2001

Psychiatric Genetics

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“…54,92,93 Alternative studies have used an adenine (A1, not cut by restriction enzyme PLA2G4A, rs10798059, intron one adenine/guanine variant (BanI)) or guanine (A2, cut by BanI) variant in the first intron of PLA2G4A, rs10798059 (BanI). 94 The A2 allele of BanI has been associated with schizophrenia under both case/control and transmission disequilibrium test (TDT) models (Table 3). [94][95][96][97][98] Five additional studies have not replicated any association between the BanI locus and schizophrenia.…”

Section: Pla2g4amentioning

confidence: 99%

“…94 The A2 allele of BanI has been associated with schizophrenia under both case/control and transmission disequilibrium test (TDT) models (Table 3). [94][95][96][97][98] Five additional studies have not replicated any association between the BanI locus and schizophrenia. 96,[99][100][101][102] Testing of markers across the chromosome region containing PLA2G4A make it unlikely that association is due to linkage disequilibrium (LD) with a nearby gene.…”

Section: Pla2g4amentioning

confidence: 99%

The role of phospholipases A2 in schizophrenia

Law¹,

Cotton²,

Berger

2006

Mol Psychiatry

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A range of neurotransmitter systems have been implicated in the pathogenesis of schizophrenia based on the antidopaminergic activities of antipsychotic medications, and chemicals that can induce psychotic-like symptoms, such as ketamine or PCP. Such neurotransmitter systems often mediate their cellular response via G-protein-coupled release of arachidonic acid (AA) via the activation of phospholipases A2 (PLA2s). The interaction of three PLA2s are important for the regulation of the release of AA -phospholipase A2 Group 2 A, phospholipase A2 Group 4A and phospholipase A2 Group 6A. Gene variations of these three key enzymes have been associated with schizophrenia with conflicting results. Preclinical data suggest that the activity of these three enzymes are associated with monoaminergic neurotransmission, and may contribute to the differential efficacy of antipsychotic medications, as well as other biological changes thought to underlie schizophrenia, such as altered neurodevelopment and synaptic remodelling. We review the evidence and discuss the potential roles of these three key enzymes for schizophrenia with particular emphasis on published association studies.

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“…were associated with schizophrenia [24][25][26][27]. Moreover, MDD [19] and IFN-αinduced depression associated somatic symptoms [21] have been associated with GG genotype of BanI polymorphism of the cPLA2 gene, while development of major depression has been associated with COX-2 rs4648308 AG genotype [21].…”

Section: Introductionmentioning

confidence: 99%

BanI polymorphism of cytosolic phospholipase A2 gene and somatic symptoms in medication-free acute depressed patients

Chang

Guu

Chen

et al. 2018

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Somatic symptoms are commonly seen in patients with major depressive disorder (MDD) and might be associated with inflammatory activation. Cytosolic phospholipase A2 (cPLA2) and cyclo-oxygenase-2 (COX-2) are the key enzymes in the metabolism of polyunsaturated fatty acids (PUFAs), which in turn may play an important role in inflammation and somatic symptoms in depression. This study investigated the effects of BanI polymorphism of cPLA2 gene and COX-2 rs4648308 genotypes on somatic symptoms and inflammatory marker in patients with MDD.Eighty-two patients with MDD were assessed for their psychopathology including 2 psychiatric and somatic symptoms, BanI polymorphism of cPLA2 and COX-2 rs4648308 genotypes and CRP levels. The results revealed that MDD patients with the cPLA2 BanI GG genotypes had higher somatic symptoms and higher levels of C-reactive protein (CRP), while no differences were found among the COX-2 rs4648308 genotypes. Inflammatory process, such as arachidonic acid cascade pathway, might help explain the effect of cPLA2 BanI polymorphism on the somatic symptoms, and may be a potential target for future investigation on treatment for MDD with somatic symptoms. However, the interpretation of the findings in this study is limited since we analyzed the data from a subset data from a larger study.

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Association of the Ban 1 dimorphic site at the human cytosolic phospholipase A2 gene with schizophrenia

Cited by 50 publications

References 0 publications

Association studies of cytosolic phospholipase A2 polymorphisms and schizophrenia among two independent family-based samples

Association studies of cytosolic phospholipase A2 polymorphisms and schizophrenia among two independent family-based samples

The role of phospholipases A2 in schizophrenia

BanI polymorphism of cytosolic phospholipase A2 gene and somatic symptoms in medication-free acute depressed patients

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