1998
DOI: 10.1097/00041444-199800830-00010
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Association of the Ban 1 dimorphic site at the human cytosolic phospholipase A2 gene with schizophrenia

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Cited by 50 publications
(26 citation statements)
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“…The fact that certain polyunsaturated fatty acids, particularly arachidonic acid and docosahexaneoic acid, are significantly depleted in membrane phospholipids from patients with schizophrenia, and the recent reports of significant reductions in positive symptoms in patients after essential fatty acids supplementation (Peet, 1999), makes cPLA2 gene an interesting candidate gene in schizophrenia genetics. To date, two polymorphisms at the cPLA2 locus have been reported to be associated with schizophrenia Peet et al, 1998).…”
Section: Discussionmentioning
confidence: 99%
“…The fact that certain polyunsaturated fatty acids, particularly arachidonic acid and docosahexaneoic acid, are significantly depleted in membrane phospholipids from patients with schizophrenia, and the recent reports of significant reductions in positive symptoms in patients after essential fatty acids supplementation (Peet, 1999), makes cPLA2 gene an interesting candidate gene in schizophrenia genetics. To date, two polymorphisms at the cPLA2 locus have been reported to be associated with schizophrenia Peet et al, 1998).…”
Section: Discussionmentioning
confidence: 99%
“…54,92,93 Alternative studies have used an adenine (A1, not cut by restriction enzyme PLA2G4A, rs10798059, intron one adenine/guanine variant (BanI)) or guanine (A2, cut by BanI) variant in the first intron of PLA2G4A, rs10798059 (BanI). 94 The A2 allele of BanI has been associated with schizophrenia under both case/control and transmission disequilibrium test (TDT) models (Table 3). [94][95][96][97][98] Five additional studies have not replicated any association between the BanI locus and schizophrenia.…”
Section: Pla2g4amentioning
confidence: 99%
“…94 The A2 allele of BanI has been associated with schizophrenia under both case/control and transmission disequilibrium test (TDT) models (Table 3). [94][95][96][97][98] Five additional studies have not replicated any association between the BanI locus and schizophrenia. 96,[99][100][101][102] Testing of markers across the chromosome region containing PLA2G4A make it unlikely that association is due to linkage disequilibrium (LD) with a nearby gene.…”
Section: Pla2g4amentioning
confidence: 99%
“…were associated with schizophrenia [24][25][26][27]. Moreover, MDD [19] and IFN-αinduced depression associated somatic symptoms [21] have been associated with GG genotype of BanI polymorphism of the cPLA2 gene, while development of major depression has been associated with COX-2 rs4648308 AG genotype [21].…”
Section: Introductionmentioning
confidence: 99%