Association of the 5HTR2A gene with suicidal behavior: CASE-control study and updated meta-analysis

Abstract

BackgroundThe polymorphism rs6313 (T102C) has been associated with suicidal behavior in case–control and meta-analysis studies, but results and conclusions remain controversial. The aim of the present study was to examine the association between T102C with suicidal behavior in a case–control study and, to assess the combined evidence – this case–control study and available data from other related studies – we carried out a meta-analysis.MethodsWe conducted a case–control study that included 161 patients with suicide attempts and 244 controls; we then performed a meta-analysis. The following models were evaluated in the meta-analysis: A) C allele vs T allele; B) T allele vs C allele; C) Caucasian population, D) Asian population, and E) suicide attempters with schizophrenia.ResultsWe found an association between attempted suicide and control participants for genotype (χ2=6.28, p=0.04, df=2) and allele (χ2=6.17, p=0.01, df=1, OR 1.48 95% IC: 1.08-2.03) frequencies in the case–control study. The meta-analysis, comprising 23 association studies (including the present one), showed that the rs6313 polymorphism is not associated with suicidal behavior for the following comparisons:T allele vs C allele (OR: 1.03; 95% CI 0.93-1.13; p(Z)=0.44); C allele vs T allele: (OR:0.99; 95% CI: 0.90-1.08; p(Z)=0.22); Caucasians (OR:1.09; 95% CI: 0.96-1.23), and Asians (OR:0.96; 95% CI: 0.84-1.09).ConclusionOur results showed association between the rs6313 (T102C) polymorphism and suicidal behavior in the case–control study. However, the meta-analysis showed no evidence of association. Therefore, more studies are necessary to determine conclusively an association between T102C and suicidal behavior.

Serotonin toxicity from antidepressant overdose and its association with the T102C polymorphism of the 5-HT2A receptor

“…10 There is no clear association with this polymorphism and depression, 11,12 schizophrenia 13 or bipolar affective disorder, 14 and also no association has been found with suicidal behaviour or ideation. [15][16][17][18] However, this polymorphism has been shown to have an association with treatment outcomes following treatment with clozapine, which modifies serotonergic activity in the brain, 19 and the 5-HT 2A polymorphism has also been investigated for a possible role in antidepressant treatment outcomes, but results to date have shown only marginal significance or no association. 11,20,21 These polymorphisms may also be associated with the severity of adverse effects from the SSRI group of antidepressant medications.…”

Interaction between Methylation and CpG Single-Nucleotide Polymorphisms in the HTR2A Gene: Association Analysis with Suicide Attempt in Schizophrenia

“…A meta-analysis analyzing the T102C variant found no association with suicidal behavior [9]. An updated meta-analysis on the same SNP [22] confirmed the lack of association with suicidal behavior.…”

Influence of T102c Polymorphism of the 5-Htr2a Gene on Clinical Characteristics of Paranoid Schizophrenia

“…Несколько других исследований также показали связь между геном 5-HTR2A и суицидальным поведением [6,9], указав на заметное увеличение риска суицидального поведения у носителей аллеля С для полиморфизма T102C гена 5-HTR2A. Тем не менее авторы проведенного в 2013 г. мета-анализа опровергают наличие какой-либо связи гена рецептора серотонина типа 2А с суицидальностью [5].…”