Association of the 3050G>C Polymorphism in the Cyclooxygenase 2 Gene with Systemic Sarcoidosis

Associations between the angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to sarcoidosis: A meta-analysis

“…[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]32,33,41 One study was excluded because it contained a polymorphism different from the ACE I/D polymorphism. 33 Thus, a total of 17 studies met our inclusion criteria.…”

“…[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]32,33,41 One study was excluded because it contained a polymorphism different from the ACE I/D polymorphism. 33 Thus, a total of 17 studies met our inclusion criteria. [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]32,41 Two eligible studies contained data on two different sarcoidosis groups, 19,22 and these were treated independently.…”

Genetics of Sarcoidosis

“…In a Spanish cohort, there was an association between the CC genotype of the COX2.8473 polymorphism and increased risk of sarcoidosis [121] and an association of the C-allele of the COX2.3050 with systemic sarcoidosis versus non-systemic sarcoidosis [122].…”

Prognostic Factors in Sarcoidosis

“…CARD15/NOD 2 polymorphisms in the caspase recruitment domain and receptor for CC chemokine genes, which is common both in sarcoidosis and Crohn disease patients, may be responsible for severe courses of sarcoidosis (Sato et al , 2010b). Other examples are increased risk of chronic or systemic sarcoidosis in patients with functional polymorphisms in COX-2 gene (Lopez-Campos et al, 2008), ACE gene (Tahir et al, 2007) or TNF-α gene (Kieszko et al, 2011;Sehan et al, 2008). The strong linkage was found between the -308G>A TNF-α (of positive prognostic value) and HLA DRB1*03 genes (Wijnen et al, 2010).…”