Association of the -250G/A promoter polymorphism of the hepatic lipase gene with the risk of peripheral arterial disease in type 2 diabetic patients

Valdivielso, Pedro; Ariza, María José; Vega-Román, Cristobal de la; González-Alegre, Teresa; Rioja, José; Ulzurrun, Eugenia; González-Santos, Pedro

doi:10.1016/j.jdiacomp.2007.06.011

Cited by 16 publications

(19 citation statements)

References 21 publications

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“…A previous cross-sectional study on lower limb arterial disease has documented an impact of the −250A variant, which is in linkage disequilibrium with the −514T [27]. More recently, the same variant was found associated with ABI among diabetics [28]. The present study extends these observations to the most common −514 T in CAD-patients, in whom ABI was demonstrated to be a prognosis factor.…”

Section: Discussionsupporting

confidence: 79%

Association of Hepatic Lipase -514T Allele with Coronary Artery Disease and Ankle-Brachial Index, Dependence on the Lipoprotein Phenotype: The GENES Study

et al. 2013

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ObjectivesRelationship between hepatic lipase (LIPC) polymorphism and coronary artery disease (CAD) has often led to contradictory results. We studied this relation by genotyping rs1800588 in the LIPC promoter in a case-control study on CAD (the GENES study). We also investigated the relationship between this polymorphism and the ankle-brachial index (ABI), which is predictive of atherosclerosis progression and complications in patients at high cardiovascular risk.Methods557 men aged 45–74 with stable coronary artery disease and 560 paired controls were genotyped for rs1800588. Medical data, clinical examination including determination of ABI and biological measurements related to cardiovascular risk factors enabled multivariate analyses and multiple adjustments.ResultsCAD cases showed a higher T-allele frequency than controls (0.246 vs 0.192, p = 0.003). An interaction has been found between LIPC polymorphism and triglycerides (TG) levels regarding risk of CAD: TT-homozigosity was associated with an Odds ratio (OR) of 6.4 (CI: 1.8–22.3) when TG were below 1.5 g/L, but no association was found at higher TG levels (OR = 1.34, CI: 0.3–5.9). The distribution of LIPC genotypes was compared between CAD patients with normal or abnormal ABI and impact of LIPC polymorphism on ABI was determined. Following multiple adjustments, association of the T-allele with pejorative ABI (<0.90) was significant for heterozygotes and for all T-carriers (OR = 1.55, CI: 1.07–2.25).ConclusionThe -514T LIPC allele is associated with CAD under normotriglyceridemic conditions and constitutes an independent determinant of pejorative ABI in coronary patients.

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Section: Discussionsupporting

confidence: 79%

Association of Hepatic Lipase -514T Allele with Coronary Artery Disease and Ankle-Brachial Index, Dependence on the Lipoprotein Phenotype: The GENES Study

et al. 2013

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“…Indeed, these two measures may represent the heterogeneity of atherosclerosis pathophysiology: while cIMT represent the thickening of intima‐media, an area that increases according to aging and smooth muscle hypertrophy, plaque is specific for evident atherosclerosis (Naqvi and Lee, ; Weber et al, ). So far, the SNV LIPC rs2070895 was only related with increased risk of peripheral vascular disease, ischemic heart disease, and CAD risk in different populations (Andersen et al, ; de Andrade et al, ; Eller et al, ; Valdivielso et al, ). However, a meta‐analysis of 11,906 cases and 13,273 health controls suggests that both SNVs LIPC rs2070895 and ‐514C/T (rs1800588) are not associated with susceptibility to coronary heart disease (Wang et al, ).…”

Section: Discussionmentioning

confidence: 99%

Lipase C, Hepatic Type −250A/G (rs2070895) Variant Enhances Carotid Atherosclerosis in Normolipidemic and Asymptomatic Individuals from Brazil

Zago

Parra

Virginio

et al. 2020

Lipids

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The common genetic variant in the promoter region of the hepatic lipase gene [LIPC −250G/A (rs2070895)] has an ambiguous association with cardiovascular disease. In this context, our study was performed to identify the relationships between the rs2070895 with carotid atherosclerosis, plasma lipids, and parameters of reverse cholesterol transport. A total of 285 normolipidemic and asymptomatic participants from an initial sample of 598,288 individuals (inclusion criteria: LDL-C ≤130 mg/dL and triglycerides ≤150 mg/dL; age: 20-75 years, both genders; confirmation of clinical, anthropometric and laboratory data; attended all visits; DNA was achieved to perform genetic analysis) were enrolled and the rs2070895 variant was genotyped by

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“…Известно, что редкие случаи недостаточности этого фермента ведут к развитию гиперхолестеринемии. В исследуемом полиморфизме 250 G/A носительство алеля А приводит к снижению синтеза печёночной липазы и является фактором, предрасполагающим к развитию атеросклероза нижних конечностей у больных сахарным диабетом 2го типа [21].…”

Section: The Role Of Genetic Polymorphism In the Formation Of Atherosunclassified

The role of genetic polymorphism in the formation of atherosclerosis in the vessels of lower extremities

et al. 2012

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Personalized medicine involves the use of methods of genomics and proteomics by physicians for early diagnosis, prediction of the nature of the disease course and the choice of medicines and their doses based on personalized characteristics of the individual patient. Advances in the study of the human genome make it possible to reveal the interrelation between the individual mutations in the human genes (polymorphisms) and predisposition to certain diseases. Currently there are more than 10 million single-nucleotide polymorphisms in the human genome, however their biological role remains poorly understood. On the basis of a literature search of electronic full-text and abstract-only versions of articles, which was conducted in the PUBMED, OMIM and GENE databases, collected was the information on genetic predisposition to systemic atherosclerosis. The review is dedicated to polymorphisms of the major genes that play a role in the pathophysiology of atherosclerosis of the lower extremities.

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Association of the -250G/A promoter polymorphism of the hepatic lipase gene with the risk of peripheral arterial disease in type 2 diabetic patients

Cited by 16 publications

References 21 publications

Association of Hepatic Lipase -514T Allele with Coronary Artery Disease and Ankle-Brachial Index, Dependence on the Lipoprotein Phenotype: The GENES Study

Association of Hepatic Lipase -514T Allele with Coronary Artery Disease and Ankle-Brachial Index, Dependence on the Lipoprotein Phenotype: The GENES Study

Lipase C, Hepatic Type −250A/G (rs2070895) Variant Enhances Carotid Atherosclerosis in Normolipidemic and Asymptomatic Individuals from Brazil

The role of genetic polymorphism in the formation of atherosclerosis in the vessels of lower extremities

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