Association of the 1q25 diabetes-specific coronary heart disease locus with alterations of the γ-glutamyl cycle and increased methylglyoxal levels in endothelial cells
Abstract:A chromosome 1q25 variant
(rs10911021) has been associated with coronary heart disease (CHD) in type 2
diabetes (T2D). In human umbilical vein endothelial cells (HUVECs), the risk
allele ‘C’ is associated with lower expression of the adjacent gene <i>GLUL</i> encoding glutamine synthase,
converting glutamic acid to glutamine. To further investigate the mechanisms
through which this locus affects CHD risk, we measured 35 intracellular
metabolites involved in glutamic acid metabolism and g-gl… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.