Association of testosterone levels with socio-demographic characteristics in a sample of Ugandan men

Nansunga, Miriam; Manabe, Yukari C.; Alele, Paul E.; Kasolo, Josephine

doi:10.4314/ahs.v14i2.9

Cited by 3 publications

(2 citation statements)

References 32 publications

(53 reference statements)

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“…In relation to our study, it makes sense to note that Maasai, as Nilotic people of East Africa, are rather tall and skinny. The level of testosterone in men from such populations is usually lower, compared to men of Caucasian origin from western populations [ 56 ]. On the other hand, testosterone level does not differ much in different age groups, in contrast to men from western populations [ 57 , 58 ], and their reproduction life extends to 70 th year and even further.…”

Section: Introductionmentioning

confidence: 99%

Facial and body sexual dimorphism are not interconnected in the Maasai

Butovskaya

Rostovtseva

Mezentseva

2022

J Physiol Anthropol

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Background In this paper, we investigate facial sexual dimorphism and its’ association with body dimorphism in Maasai, the traditional seminomadic population of Tanzania. We discuss findings on other human populations and possible factors affecting the developmental processes in Maasai. Methods Full-face anthropological photographs were obtained from 305 Maasai (185 men, 120 women) aged 17–90 years. Facial shape was assessed combining geometric morphometrics and classical facial indices. Body parameters were measured directly using precise anthropological instruments. Results Sexual dimorphism in Maasai faces was low, sex explained 1.8% of the total shape variance. However, male faces were relatively narrower and vertically prolonged, with slightly wider noses, narrower-set and lower eyebrows, wider mouths, and higher forehead hairline. The most sexually dimorphic regions of the face were the lower jaw and the nose. Facial width-to-height ratio (fWHR), measured in six known variants, revealed no significant sexual dimorphism. The allometric effects on facial traits were mostly related to the face growth, rather than the growth of the whole body (body height). Significant body dimorphism was demonstrated, men being significantly higher, with larger wrist diameter and hand grip strength, and women having higher BMI, hips circumferences, upper arm circumferences, triceps skinfolds. Facial and body sexual dimorphisms were not associated. Conclusions Facial sex differences in Maasai are very low, while on the contrary, the body sexual dimorphism is high. There were practically no associations between facial and body measures. These findings are interpreted in the light of trade-offs between environmental, cultural, and sexual selection pressures.

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Section: Introductionmentioning

confidence: 99%

Facial and body sexual dimorphism are not interconnected in the Maasai

Butovskaya

Rostovtseva

Mezentseva

2022

J Physiol Anthropol

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“…Testosterone was produced by both men and women with 10-fold higher levels of circulating in men than that in women. It is significantly correlated with several physiological processes, such as sperm production, energy, strength, sexual behavior, sleep, mood, and the general well-being of men . Whatever, being fundamental for the development and maintenance of male characteristics and male sexual organs, testosterone also has effects on most major organs, such as the brain, muscle, kidney, bone, liver, and skin .…”

Section: Introductionmentioning

confidence: 99%

Generation of Small Single Domain Nanobody Binders for Sensitive Detection of Testosterone by Electrochemical Impedance Spectroscopy

Zhu

et al. 2016

ACS Appl. Mater. Interfaces

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A phage display library of variable domain of the heavy chain only antibody or nanobody (Nb) was constructed after immunizing a bactrian camel with testosterone. With the smaller molecular size (15 kDa), improved solubility, good stability, high affinity, specificity, and lower immunogenicity, Nbs are a promising tool in the next generation of diagnosis and medical applications. Testosterone is a reproductive hormone, playing an important role in normal cardiac function and being the highly predictive marker for many diseases. Herein, a simple and sensitive immunosensor based on electrochemical impedance spectroscopy (EIS) and Nbs was successfully developed for the determination of testosterone. We successfully isolated the antitestosterone Nbs from an immune phage display library. Moreover, one of the Nbs was biotinylated according to in vivo BirA system, which showed the highest production yield and the most stable case. Further, the EIS immunosensor was set up for testosterone detection by applying the biotinylated antitestosterone Nb. As a result, the biosensor exhibited a linear working range from 0.05 to 5 ng mL(-1) with a detection limit of 0.045 ng mL(-1). In addition, the proposed immunosensor was successfully applied in determining testosterone in serum samples. In conclusion, the proposed immunosensor revealed high specificity of testosterone detection and showed as a potential approach for sensitive and accurate diagnosis of testosterone.

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