Association of T-box gene polymorphisms with the risk of Wolff–Parkinson–White syndrome in a Han Chinese population

Abstract

Abnormal development of the atrioventricular ring can lead to the formation of a bypass pathway and the occurrence of Wolff–Parkinson–White (WPW) syndrome. The genetic mechanism underlying the sporadic form of WPW syndrome remains unclear. Existing evidence suggests that both T-box transcription factor 3 ( TBX3 ) and T-box transcription factor 2 ( TBX2 ) genes participate in regulating annulus fibrosus formation and atrioventricular canal development. Thus, we aimed to examine whether single-nucleotide polymorphisms (SNPs) in the TBX3 and TBX2 genes confer susceptibility to WPW syndrome in a Han Chinese Population. We applied a SNaPshot SNP assay to analyze 5 selected tagSNPs of TBX3 and TBX2 in 230 patients with sporadic WPW syndrome and 231 sex- and age-matched controls. Haplotype analysis was performed using Haploview software. Allele C of TBX3 rs1061657 was associated with a higher risk of WPW syndrome (odds ratio [OR] = 1.41, 95% confidence interval [CI]: 1.08–1.83, P = .011) and left-sided accessory pathways (OR = 1.40, 95% CI: 1.07–1.84, P = .016). However, allele C of TBX3 rs8853 was likely to reduce these risks (OR = 0.71, 95% CI: 0.54–0.92, P = .011; OR = 0.70, 95% CI: 0.53–0.92, P = .011, respectively). The data revealed no association between TBX3 rs77412687, TBX3 rs2242442, or TBX2 rs75743672 and WPW syndrome. TBX3 rs1061657 and rs8853 are significantly associated with sporadic WPW syndrome among a Han Chinese population. To verify our results, larger sample sizes are required in future studies.

Clinical, electrophysiological, molecular, and genetic characteristics of patients with Wolf–Parkinson–White syndrome: literature review

“…Частоты аллеля С и генотипа CC rs1061657 оказались выше у пациентов основной, чем лиц контрольной группы (ОШ=1,41, 95% ДИ 1,09-1,83, p=0,010 и ОШ=2,24, 95% ДИ 1,25-3,99, p=0,006 соответственно), тогда как аллель C и генотип CC rs8853 встречались чаще среди лиц контрольной группы (ОШ=0,70, 95% ДИ 0,54-0,92, p=0,010 и ОШ=0,44, 95% ДИ 0,23-0,83, p=0,011 соответственно) . Таким образом, результаты исследования показали, что аллель C rs1061657 может быть связан с более высоким риском развития синдрома WPW, тогда как аллель C rs8853, вероятно, снижает его частоту [26] .…”