Association of Systemic Inflammation Score With Atrial Fibrillation: A Case-Control Study With Propensity Score Matching

Zhang, Huan; Li, Jun; Chen, Xinghua; Wu, Na; Xie, Wenting; Tang, He; Li, Chengying; Wu, Long; Xiang, Ying; Zhong, Li; Li, Yafei

doi:10.1016/j.hlc.2017.04.007

Cited by 36 publications

(45 citation statements)

References 31 publications

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“…Nevertheless, uncontrolled inflammation constitutes a positive feedback loop that can lead to numerous unintended diseases (20). There is considerable evidence to support a direct relationship between inflammation and AF (31). For example, new-onset AF has been observed frequently in the critically ill or in patients with sepsis (32,33).…”

Section: Evidence Of a Relationship Between Systemic Inflammation And Afmentioning

confidence: 99%

Evidence for Inflammation as a Driver of Atrial Fibrillation

Zhou

Dudley

2020

Front. Cardiovasc. Med.

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Atrial fibrillation (AF) is one of the most common types of arrhythmias and increases cardiovascular morbidity and mortality. Current therapeutic approaches to AF that focus on rhythm control have high recurrence rates and no life prolongation value. While possible explanations include toxicity of current therapies, another likely explanation may be that current therapies do not address fundamental mechanisms of AF initiation and maintenance. Inflammation has been shown to affect signaling pathways that lead to the development of AF. This paper reviews the roles of inflammation in the occurrence, development, and mechanisms of AF and reviews the therapeutic implications of the correlation of inflammation and AF.

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Section: Evidence Of a Relationship Between Systemic Inflammation And Afmentioning

confidence: 99%

Evidence for Inflammation as a Driver of Atrial Fibrillation

Zhou

Dudley

2020

Front. Cardiovasc. Med.

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“…27 In other medical diseases, such atrial fibrillation, a previous study also demonstrated that patients with higher SIS had a significantly higher risk of atrial fibrillation and SIS was further correlated with atrial diameter. 28 In the current study, patients with OSCC who had a higher SIS were also associated with many other poor clinicopathological factors such as older age, advanced tumor status, tumor depth, advanced overall pathologic stage, extranodal extension, and perineural invasion; in additional multivariate analyses, SIS was shown to be an independent factor and could be used to predict prognosis better.…”

Section: Discussionmentioning

confidence: 50%

The Prediction Value of the Systemic Inflammation Score for Oral Cavity Squamous Cell Carcinoma

Eltohami

Kao

Lao

et al. 2018

Otolaryngol.--head neck surg.

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Objectives This study aimed to investigate the potential prognostic role of the oral cancer systemic inflammation score (SIS) based on serum albumin levels and the lymphocyte-to-monocyte ratio in patients with oral squamous cell carcinoma (OSCC) after treatment. Study Design A retrospective cohort study. Setting Tertiary care center. Subjects and Methods The study involved 613 patients who were treated for OSCC between September 2005 and December 2014. The association of the oral cancer SIS with various clinicopathological features was investigated. A nomogram based on different clinicopathological features and SIS was established to predict prognosis. Results Higher SIS was significantly associated with older age ( P = .0013), advanced tumor status ( P < .0001), tumor depth ( P < .0001), advanced overall pathologic stage ( P < .0001), and extranodal extension ( P = .0045), as well as the presence of perineural invasion ( P = .0341). Higher SIS, older age, overall stage, and extranodal extension were demonstrated to be independent prognostic indicators for shorter overall survival ( P < .0001). A nomogram comprising SIS, TNM stage, and the degree of cell differentiation, as well as perineural invasion and extranodal extension, was developed to predict the prognosis of these patients. The c-index of the nomogram model based on TNM staging only was 0.688 and could be increased to 0.752 if SIS and several other clinicopathological parameters were incorporated. Conclusions Higher SIS is associated with many poor prognosticators, and the nomogram that was established and based on the incorporation of SIS might strengthen the prediction of prognosis in patients with OSCC.

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“…As shown in Table 2, Bacteroidales and Firmicutes seemed to display an association with NCCL risk, although the association was not statistically significant ( Bacteroidales, P = 0.056; Firmicutes, P = 0.066), while Actinomycetales , Clostridiales and Fusobacteriales exhibited statistically significant differences (Actinomycetales, P = 0.023; Clostridiales, P = 0.011). Among these, Fusobacteriales showed an extremely significant difference ( P = 0.000345, t = 3.932) between the normal group and the NCCL group 23 …”

Section: Resultsmentioning

confidence: 96%

“…Among these, Fusobacteriales showed an extremely significant difference (P = 0.000345, t = 3.932) between the normal group and the NCCL group. 23…”

Section: Paired T Test Analysismentioning

confidence: 99%

Study of oral microorganisms contributing to non‐carious cervical lesions via bacterial interaction and pH regulation

Huang

Lin

Liu

et al. 2021

J Cellular Molecular Medi

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There is a lack of evidence about the relationship between microorganisms and non‐carious cervical lesions (NCCLs) due to limited technologies. A group of 78 patients was enrolled for microbial 16S rRNA sequencing of dental plaques on normal and defective cervical surfaces. Parallel data from 39 patients were analysed with paired t tests, and Fusobacteriales exhibited significantly less distribution on NCCLs than on normal surfaces. As a result, Fusobacterium nucleatum, the most common oral bacterial strain belonging to the order Fusobacteriales, was selected for further research. From a scanning electron microscopy (SEM) scan, the tooth surface with Fusobacterium nucleatum and Streptococcus mutans culture was more intact than that without Fusobacterium nucleatum. Furthermore, the calcium contents in groups with Fusobacterium nucleatum were significantly higher than that without it. In further mechanistic research, Fusobacterium nucleatum was demonstrated to adhere to and disturb other organisms as well as producing alkaline secretions to neutralize the deleterious acidic environment, protecting the tooth structure. In conclusion, microorganisms and NCCLs were confirmed directly related through adherent bacterial interactions and pH regulation. The research provides a new perspective and experimental evidence for the relation between microorganisms and NCCLs, which guides clinical treatment and preventive dentistry in the future.

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Association of Systemic Inflammation Score With Atrial Fibrillation: A Case-Control Study With Propensity Score Matching

Cited by 36 publications

References 31 publications

Evidence for Inflammation as a Driver of Atrial Fibrillation

Evidence for Inflammation as a Driver of Atrial Fibrillation

The Prediction Value of the Systemic Inflammation Score for Oral Cavity Squamous Cell Carcinoma

Study of oral microorganisms contributing to non‐carious cervical lesions via bacterial interaction and pH regulation

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