Association of systemic and thyroid autoimmune diseases

Biró, Edit; Szekanecz, Zoltán; Czirják, László; Dankó, Katalin; Kiss, Emese; Szabó, Nóra Anna; Szűcs, Gabriella; Zeher, Margit; Bodolay, Edit; Szegedi, Gyula; Bakó, G

doi:10.1007/s10067-005-1165-y

Cited by 174 publications

(112 citation statements)

References 21 publications

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“…The presence of thyroid disease is particularly characteristic of type II and type III MGA syndromes, being associated with Addison's disease and diabetes mellitus respectively [31]. Several MGA syndromes including Hashimoto's thyroiditis and autoimmune diseases not involving endocrine glands have been described (pernicious anaemia, vitiligo, chronic muco-cutaneous candidiasis, systemic lupus erythematosus, rheumatoid arthritis and systemic sclerosis) [32][33][34].…”

Section: Discussionmentioning

confidence: 99%

Possible association between thyroid autoimmunity and Menière's disease

Fattori¹,

Nacci²,

Dardano³

et al. 2008

Clinical and Experimental Immunology

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SummaryVarious aetiopathological mechanisms have been postulated to be at the root of Menière's disease (MD), and some data suggest that there may be also an underlying autoimmune factor. In fact, Menière patients manifest certain characteristics that are typical of autoimmune involvement association of particular human leucocyte antigen haplotypes, the presence of antibodies against internal ear antigens. In this study, we evaluated the association between thyroid autoimmunity and MD in a non-selected group of patients. We recruited 50 consecutive MD patients and two groups as controls: group A, 82 healthy volunteers; and group B, 50 subjects suffering from acute unilateral peripheral vestibulopathy. All subjects were submitted to instrumental assessment of cochlear-vestibular function and analysis of thyroid-stimulating hormone (TSH), free triiodothyronine, free thyroxine, anti-TSH receptor antibody (TR-Ab), anti-thyroperoxidase antibody (TPO-Ab) and antithyroglobulin antibody (Tg-Ab) in the blood. The prevalence of autoimmune thyroiditis in group B [6/50 (12%); 66·7% TPO-Ab and 33·3% Tg-Ab] was superimposable with the healthy controls [6/82 (7%); 66·7% TPO-Ab and 33·3% Tg-Ab]. In contrast, 38% of the MD patients (P = 0·0001 versus group A and group B) had significant autoantibody levels (68·4% TPO-Ab; 15·8% TPO-Ab + TR-Ab; 10·5% Tg-Ab; 5·2% TPO-Ab + Tg-Ab). Furthermore, 14% of the MD patients were hyperthyroid under l-thyroxine therapy, while no dysfunction was seen in the control groups. Overall, our data demonstrate a significant association between MD and thyroid autoimmunity, which suggests that an autoimmune factor is involved in the aetiopathogenesis of this disease. These findings suggest that it should be useful to submit MD patients to multi-disciplinary clinical investigation.

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Section: Discussionmentioning

confidence: 99%

Possible association between thyroid autoimmunity and Menière's disease

Fattori¹,

Nacci²,

Dardano³

et al. 2008

Clinical and Experimental Immunology

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“…Autoimmune thyroiditis has been shown to coexist in about 23% of Sjögren syndrome diagnoses [5] and the prevalence of autoimmune thyroiditis among patients with Sjögren syndrome has been reported as 18% to 24%, respectively [7,8,23]. Autoimmune hepatitis is frequently a comorbid presentation with autoimmune thyroiditis (18.3%) and Sjögren syndrome (8.4%) [24].…”

Section: Discussionmentioning

confidence: 99%

“…Centanni et al [4] reported that about one-third of patients who presented with autoimmune thyroid disease also had atrophic gastritis. Interestingly, some investigations have reported that 20% to 24% of patients with autoimmune thyroiditis also present with Sjögren syndrome [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Multiglandular Autoimmune Diseases of the Thyroid, Salivary Gland, and Liver along with Atrophic Gastritis: A Case Report

Lee¹,

Chung

Chung³

et al. 2014

Thyroid Disorders Ther

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Multiple mechanisms have been suggested for the pathogenesis of these multiglandular autoimmune diseases. One of proposed mechanisms in the multiglandular autoimmune disease is initiated by antibodies. However, the results are not definitive and remain controversial. We investigated a woman with multiple autoimmune diseases, in whose serum the mRNA of sodium iodide symporter (NIS) was found by nested reverse transcription polymerase chain reaction (RT-PCR). In this patient, multiple autoimmune diseases were initially developed as thyroiditis, followed by Sjögren syndrome, hepatitis, and finally a diagnosis of atrophic gastritis. NIS is known to be expressed on organs affected by these diseases. The mRNA of NIS was found in the serum of this patient by nested RT-PCR. The pathogenesis of multiglandular autoimmune disease is still not clear. We suggest that anti NIS antibodies can serve as a marker to monitor the pathogenesis of multiglandular autoimmune disease.

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“…However, it is not clear how . Another study revealed chronic thyroiditis was found 21% of MCTD patients 11) . These data suggests physicians should be alert about chronic thyroiditis when they encounter patients with MCTD.…”

Section: Case Reportmentioning

confidence: 95%

A case of mixed connective tissue disease positive for proteinase 3 antineutrophil cytoplasmic antibody in a patient with slowly progressive type 1 diabetes mellitus and chronic thyroiditis

Michitsuji

Horai

Sako

et al. 2017

Jpn. J. Clin. Immunol.

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summaryA female in her sixties with slowly progressive type 1 diabetes mellitus (SPT1DM) and chronic thyroiditis was referred to our rheumatology department with swelling in her fingers. A prominent atherosclerotic lesion was revealed upon brain magnetic resonance imaging, and she was found to have mixed connective tissue disease (MCTD) positive for proteinase 3 (PR3)-antineutrophil cytoplasmic antibody (ANCA). This rare case of MCTD accompanying SPT1DM and PR3-ANCA suggested that a synergy between MCTD and PR3-ANCA triggers atherosclerosis.

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Association of systemic and thyroid autoimmune diseases

Cited by 174 publications

References 21 publications

Possible association between thyroid autoimmunity and Menière's disease

Possible association between thyroid autoimmunity and Menière's disease

Multiglandular Autoimmune Diseases of the Thyroid, Salivary Gland, and Liver along with Atrophic Gastritis: A Case Report

A case of mixed connective tissue disease positive for proteinase 3 antineutrophil cytoplasmic antibody in a patient with slowly progressive type 1 diabetes mellitus and chronic thyroiditis

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