Association of STAT4 polymorphisms with susceptibility to primary membranous glomerulonephritis and renal failure

Chen, Shih Yin; Chen, Cheng Hsu; Huang, Yu Chuen; Chan, Chia Jung; Hsieh, Yao Yuan; Yu, Min; Tsai, Chang Hai; Tsai, Fuu Jen

doi:10.1016/j.cca.2011.06.020

Cited by 12 publications

(7 citation statements)

References 32 publications

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“…In recent years, studies have found that rs7574865 of the STAT4 gene in intron 3 is closely related to rheumatoid arthritis, SLE, sclerosis, type 1 diabetes, systemic sclerosis, and other autoimmune diseases [42-45]. In order to explore the correlation between STAT4 and IMN, Chen et al [46] selected 138 patients with IMN and 265 healthy controls from the Chinese Taiwan population and detected three SNP sites of STAT4, rs3024908, rs3024912, and rs3024877. They found that IMN patients with GG genotype at rs3024908 were more likely to develop renal failure.…”

Section: Research Progress In Genetic Pathogenesismentioning

confidence: 99%

Advances in Pathogenesis of Idiopathic Membranous Nephropathy

Chen

Xiang

et al. 2020

Kidney Dis

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Background: Membranous nephropathy (MN), a major cause of nephrotic syndrome, has attracted people's attention in recent years for its growing prevalence. It is the second or third leading cause of ESRD in patients with primary glomerulonephritis and is the leading glomerulopathy that recurs after kidney transplantation. Summary: MN can be classified as idiopathic membranous nephropathy (IMN) and secondary MN. The discovery of the M-type phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A) provides the new diagnostic methods and treatment strategies for IMN on the molecular level. The study on single nucleotide polymorphism of IMN genes, such as the single M-type phospholipase A2 receptor 1 (PLA2R1) gene and human leukocyte antigen (HLA) gene, explains the pathogenesis of the disease from the perspective of genetics and conforms to the trend of the era of precision medicine. Key Messages: This review focuses on advances in the pathogenesis of IMN, including molecular and genetic pathogenesis, as well as discussing the diagnostic and treatment guiding value brought by these new discoveries.

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Section: Research Progress In Genetic Pathogenesismentioning

confidence: 99%

Advances in Pathogenesis of Idiopathic Membranous Nephropathy

Chen

Xiang

et al. 2020

Kidney Dis

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“…In search of causative factors for pMN, genetic studies were also involved that focused on genes related to inflammatory process [51,52], autoimmunity [43,54,55], and PLA2R [53,54,55]. It was shown that the TNF-α (a pro-inflammatory cytokine) gene is associated with an increased susceptibility to MN [51]; a correlation between high-risk STAT4 (transcription factor involved in inflammation) allele and higher frequency of kidney failure in MN patients was also established [52]. These findings support the role of inflammatory response and cellular injury in the pathogenesis of MN.…”

Section: Genetic Factorsmentioning

confidence: 99%

Membranous glomerulonephritis – a common, unspecific pattern of glomerular injury

Starzyńska-Kubicka¹,

Perkowska‐Ptasińska²,

Górnicka³

2018

pjp

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Membranous nephropathy (MN) is a chronic form of glomerulonephritis, associated with the presence of immune complexes beneath the podocytes on the subepithelial region of glomerular capillaries. MN is not a disease entity but one of relatively common patterns of glomerular injury that may be a manifestation of primary renal autoimmunological reaction or may evolve as a phenomenon secondary to wide spectrum of systemic processes.

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“…Table 1 displays characteristics of genetic polymorphisms in MN research across three years in Taiwan. Genes were discussed previously, all involved in pathogenesis: STAT4 , TLR9 , IL-6 , TLR4 , TRPC6 , NPHS1 , and MYH9 [ 8 - 14 ]. Our new information about polymorphisms on MYD88, ACTN4, and KIRREL2 relates to MN susceptibility.…”

Section: Genetic Association Studies On Mn Over Three Years In Taimentioning

confidence: 99%

“…STAT4 haplotype characterized by rs7574865 exhibited strong linkage with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and autoimmune disease: e.g., systemic sclerosis, Sjögren’s syndrome, Type 1 diabetes [ 18 - 22 ]. SY Chen et al (2011) reported significant difference in genotype frequency at rs3024908 SNP in MN patients versus controls (p = 0.014); those with GG genotype at rs3024912 SNP face higher risk of kidney failure in MN cases (adjusted odds ratio [OR] = 3.255; 95% confidence interval [CI] = 1.155-9.176, p = 0.026) [ 8 ].…”

Section: Transducer and Activator Of Transcription 4 (Stat4)mentioning

confidence: 99%

Genetic susceptibility to idiopathic membranous nephropathy in high-prevalence Area, Taiwan

Chen¹,

Chen²,

Huang³

et al. 2014

BioMed

Self Cite

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Idiopathic membranous nephropathy (MN) is one common cause of idiopathic nephrotic syndrome in adults; 25% of MN patients proceed to end-stage renal disease. In adults, membranous nephropathy is a lead cause of nephrotic syndrome, with about 75% of the cases idiopathic. Secondary causes include autoimmune disease, infection, drugs and malignancy. Three hypotheses about pathogenesis have surfaced: preformed immune complex, in situ immune complex formation, and auto-antibody against podocyte membrane antigen. Pathogenesis does involve immune complex formation with later deposition in sub-epithelial sites, but definite mechanism is still unknown. Several genes were recently proven associated with primary membranous nephropathy in Taiwan: IL-6, NPHS1, TLR-4, TLR-9, STAT4, and MYH9 . These may provide a useful tool for diagnosis and prognosis. This article reviews epidemiology and lends new information on KIRREL2 (rs443186 and rs447707) polymorphisms as underlying causes of MN; polymorphisms revealed by this study warrant further investigation.

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Association of STAT4 polymorphisms with susceptibility to primary membranous glomerulonephritis and renal failure

Cited by 12 publications

References 32 publications

Advances in Pathogenesis of Idiopathic Membranous Nephropathy

Advances in Pathogenesis of Idiopathic Membranous Nephropathy

Membranous glomerulonephritis – a common, unspecific pattern of glomerular injury

Genetic susceptibility to idiopathic membranous nephropathy in high-prevalence Area, Taiwan

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