Association of some supraglottic laryngeal carcinomas with EB virus

Abstract

Thin sections of biopsies from five patients with supraglottic laryngeal carcinoma who possessed antibody to early antigen of EB virus were examined for the presence of EB virus nuclear antigen (EBNA) and EB virus DNA by cytological hybridization in situ. Both EBNA and EB virus DNA were found in the tumour cells of three of the patients. The present findings suggest an association between EB virus and supraglottic carcinoma of the larynx.

Effects of Epstein-Barr Virus Infection on the Risk and Prognosis of Primary Laryngeal Squamous Cell Carcinoma: A Hospital-Based Case-Control Study in Taiwan

“…Therefore, the etiologic risk factors for primary and recurrent LSCC need to be thoroughly studied; potential risk factors include cigarette smoking, alcohol consumption, environmental carcinogens, and gene mutations [4]. According to previous studies, additional factors include human papillomavirus [4][5][6], contrary to our findings [7]; and Epstein-Barr virus (EBV) [8][9][10][11][12], contrary to various reports [5,13,14].…”

Association of Epstein‐Barr virus infection with oral squamous cell carcinoma in a case–control study

“…It is the well‐known causative agent of infectious mononucleosis and is closely associated with Burkitt's lymphoma , nasopharyngeal carcinoma, and EBV‐induced disorders in immune deficient patients . However, only a handful of other epithelial cell malignancies of the head and neck have been linked to EBV infection .…”

Epstein-Barr Virus-Associated Carcinoma of the Larynx: A Systematic Review with Meta-Analysis

“…The 31 systematically reviewed studies were carried out in 19 different countries in Europe (n = 12) [6,[10][11][12][13][14][15][16][17][18][19][20], Asia (n = 8) [21][22][23][24][25][26][27][28], North America (n = 5) [3,[29][30][31][32], Eurasia (n = 3) [4,5,33], Oceania (n = 1) [34], South America (n = 1) [2], and concomitantly in North America and Europe (n = 1) [35] (Table 1).…”

“…The studies have detected EBV by PCR-based techniques (n = 16) [3][4][5]12,13,15,17,18,21,23,25,28,[31][32][33][34], in situ hybridization (ISH) (n = 14) [2,10,12,14,16,19,20,22,[26][27][28]31,32,35], or immunological methods (n = 10) [5,10,12,14,16,24,[28][29][30]35]. In seven studies, two techniques were used for viral detection, with five studies combining immunological assays and hybridization [4,10,14,16,35]: a study using immunological and PCR-based techniques [5] and another study applying ISH and PCR-based techniques [32]. Three different techniques (ISH, immunological, and PCR-based methods) were employed in two studies…”

“…Břicháček et al [10] were the first to successfully demonstrate the presence of the EBV genome and the latent protein EBNA (Epstein-Barr virus nuclear antigen) in malignant cells of laryngeal carcinomas. The presence of viral DNA in most of the tumor cells suggested that EBV might be associated with LC, resembling EBV-infected NPC.…”