Association of Socio-economic and Demographic Factors with Indonesian Women’s Premature Menopause: Analysis of the Demographic and Health Surveys Program (DHS) of 2017

Dewi, Vonny Khresna

doi:10.31901/24566772.2021/15.1-2.627

Cited by 3 publications

(10 citation statements)

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“…A possible explanation for stalling or increasing trends in the prevalence of early and premature menopause in some regions could be, as shown in previous research, that urban and more educated women are more likely to experience early and premature menopause. 30 This is happening at the same time as women of low socio-economic groups seeing a rise as well. However, further research is needed to understand how sociodemographic and epidemiological transitions might work differently in their impact on menopause across regions.…”

Section: Discussionmentioning

confidence: 99%

“…However, further research is needed to understand how sociodemographic and epidemiological transitions might work differently in their impact on menopause across regions. 30 …”

Section: Discussionmentioning

confidence: 99%

“…As pathways to menopause are influenced by epidemiological and socio-economic factors as well as biological differences, we might be witnessing a potential faster pace of ageing due to a higher burden of ill health and more reproductive life events for both high and low socio-economic groups in LMICs 15 18. Increasing prevalence of early menopause has already been identified in Iran37 (low socio-economic status) and Indonesia30 (high socio-economic status). A possible explanation for stalling or increasing trends in the prevalence of early and premature menopause in some regions could be, as shown in previous research, that urban and more educated women are more likely to experience early and premature menopause 30.…”

Section: Discussionmentioning

confidence: 99%

“… 29 Whereas, a more recent study in Indonesia using Demographic and Health Surveys (DHS) data showed a higher prevalence of early and premature menopause among higher educated and urban women. 30 …”

Section: Introductionmentioning

confidence: 99%

“…A study in Latin America showed that women with lower incomes and lower education levels generally reported an earlier onset of menopause 29. Whereas, a more recent study in Indonesia using Demographic and Health Surveys (DHS) data showed a higher prevalence of early and premature menopause among higher educated and urban women 30…”

Section: Introductionmentioning

confidence: 99%

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Secular trends in premature and early menopause in low-income and middle-income countries

2023

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BackgroundWhile secular trends in high-income countries show an increase in the mean age at menopause, it is unclear if there is a similar pattern in low-income and middle-income countries (LMICs), where women’s exposure to biological, environmental and lifestyle determinants of menopause may differ. Premature (before age 40 years) and early (ages 40–44 years) menopause could have negative repercussions on later life health outcomes which in ageing societies could mean further stress on low-resource health systems. An evaluation of such trends in LMICs has been hampered by the suitability, quality and comparability of data from these countries.MethodsUsing 302 standardised household surveys from 1986 to 2019, we estimate trends and CIs using bootstrapping in the prevalence of premature and early menopause in 76 LMICs. We also developed a summary measure of age at menopause for women who experience menopause before the age of 50 years based on demographic estimation methods that can be used to measure menopausal status in surveys with truncated data.ResultsTrends indicate an increasing prevalence of early and premature menopause in LMICs, in particular in sub-Saharan Africa and South/Southeast Asia. These regions also see a suggested decline of the mean age at menopause with greater variation across continents.ConclusionsThis study enables the analysis of menopause timing by exploiting data generally used for the study of fertility by methodologically allowing the use of truncated data. Findings show a clear increase in prevalence of premature and early menopause in the regions with the highest fertility with possible consequences for later life health. They also show a different trend compared with high-income regions, confirming a lack of generalisability and the importance of accounting for nutritional and health transitions at the local level. This study calls for further data and research on menopause on a global scale.

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Section: Discussionmentioning

confidence: 99%

“…However, further research is needed to understand how sociodemographic and epidemiological transitions might work differently in their impact on menopause across regions. 30 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Secular trends in premature and early menopause in low-income and middle-income countries

2023

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Higher peripheral blood mitochondrial DNA copy number and relative telomere length in under 48 years Indonesian breast cancer patients

Limardi,

Panigoro,

Siregar

et al. 2024

BMC Res Notes

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Objective Breast cancer is the leading cause of cancer incidence and mortality among Indonesian women. A comprehensive investigation is required to enhance the early detection of this disease. Mitochondrial DNA copy number (mtDNA-CN) and relative telomere length (RTL) have been proposed as potential biomarkers for several cancer risks, as they are linked through oxidative stress mechanisms. We conducted a case–control study to examine peripheral blood mtDNA-CN and RTL patterns in Indonesian breast cancer patients (n = 175) and healthy individuals (n = 181). The relative ratios of mtDNA-CN and RTL were determined using quantitative real-time PCR (qPCR). Results Median values of mtDNA-CN and RTL were 1.62 and 0.70 in healthy subjects and 1.79 and 0.73 in breast cancer patients, respectively. We found a positive association between peripheral blood mtDNA-CN and RTL (p < 0.001). In under 48 years old breast cancer patients, higher peripheral blood mtDNA-CN (mtDNA-CN ≥ 1.73 (median), p = 0.009) and RTL (continuous variable, p = 0.010) were observed, compared to the corresponding healthy subjects. We also found a significantly higher ‘High-High’ pattern of mtDNA-CN and RTL in breast cancer patients under 48 years old (p = 0.011). Our findings suggest that peripheral blood mtDNA-CN and RTL could serve as additional minimally invasive biomarkers for breast cancer risk evaluation.

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Factors predicting age at menopause among Iranian women in the Bandare-Kong cohort study (a cross-sectional survey of PERSIAN cohort study)

Kutenaee,

Dashti,

Rafati

et al. 2023

womens midlife health

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Background Menopause is a natural period in women’s life and can be affected by several factors. The aim of this study was to identify the associated factors for age of natural menopause and among women with early and premature menopause based on a cohort study in Iran. Methods This population-based study was conducted on 894 post menopause women between 35 and 70 years old who participated in the Bandare-Kong Non-Communicable Diseases (BKNCD) Cohort Study, a part of Prospective Epidemiological Research Studies in Iran (PERSIAN) from March 2016 to February 2019. All women completed a standard self-reported questionnaire. Data were analyzed using chi-square test, independent t test, and ANOVA as well as a multivariable linear regression model. Results The mean age at natural menopause was 48.31 ± 6.34 years. After adjusting other variables, gravida, history of cardiac disease, socioeconomic status and residence status were predictive of age at menopause (P < 0.001). Among the premature menopause group, the mean age at menopause was significantly higher among women with diabetes compared to women without diabetes group (35.68 ± 2.92 vs. 33.82 ± 3.06; P = 0.043), while the mean age at menopause was significantly lower in women with infertility compared to women without infertility (29.13 ± 5.22 vs. 34.84 ± 2.826; P = 0.048). Conclusions This study suggests that the predictors of menopausal age differed in women with premature menopause compared to overall menopause age. Prospective studies are needed to evaluation the effects of these factors on menopausal age.

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Association of Socio-economic and Demographic Factors with Indonesian Women’s Premature Menopause: Analysis of the Demographic and Health Surveys Program (DHS) of 2017

Cited by 3 publications

References 0 publications

Secular trends in premature and early menopause in low-income and middle-income countries

Secular trends in premature and early menopause in low-income and middle-income countries

Higher peripheral blood mitochondrial DNA copy number and relative telomere length in under 48 years Indonesian breast cancer patients

Factors predicting age at menopause among Iranian women in the Bandare-Kong cohort study (a cross-sectional survey of PERSIAN cohort study)

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