Association of SNPs/haplotypes in promoter of TNF A and IL-10 gene together with life style factors in prostate cancer progression in Indian population

Abstract

According to our data, TNF A -238G>A and IL-10 -1082A>G, -819C>T and -592C>A may be associated with the development of prostate cancer and BPH. We could also notice higher frequency of TNF A and IL-10 risk haplotypes in smoker and alcohol user. Interestingly, IL-10 risk haplotype was positively associated with aggressiveness of tumor. This information can be used for the early diagnosis of disease and to improve tissue-specific treatment's efficacy which will be moving ultimately towards the discovery of personalized therapy.

No association between three polymorphisms (rs1800629, rs361525 and rs1799724) in the tumor necrosis factor-α gene and susceptibility to prostate cancer: a comprehensive meta-analysis

“…To the best of our knowledge, for the rs1799724 [15,16,35] polymorphism, which was analyzed for the first time, no significant association was detected from 3 studies, which included 2914 cases and 3121 controls. For the rs361525 polymorphism [15,20,21,24,28,30,35], pooled significant relationships were observed in the genotyping method subgroups. Cumulatively, we believe no association exists between the four common TNF-α polymorphisms and PCA risk based on the current evidence.…”

“…Taken together, these observations indicate that the detection of inflammation in the prostate may be helpful for us to better identify PCA patients; however, there are no specific biomarkers of prostate inflammation to date. Studying both pro-and anti-inflammatory cytokine genes is essential for PCA [21]. TNF-α, as a main mediator of inflammation, has a vital role in PCA development [10].…”

“…Therefore, a current, updated meta-analysis with a comprehensive assessment that included more eligible studies was performed to evaluate the impact of TNF-α gene polymorphisms (rs1800629, rs361525 and rs1799724) on PCA susceptibility, which may overcome the aforementioned disadvantages [15,16,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]. For the TNF-α rs1800629 polymorphism, the findings from 20 studies, including 6936 cases and 7619 controls, did not support an association between this variant and PCA risk [15,16,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]. To the best of our knowledge, for the rs1799724 [15,16,35] polymorphism, which was analyzed for the first time, no significant association was detected from 3 studies, which included 2914 cases and 3121 controls.…”

“…Ma et al, however, suggested that the rs361525 polymorphism was not associated with PCA, and the rs1800629 polymorphism, which is also the susceptible SNP for PCA, only had a significant association in healthy volunteers (AG vs. GG: OR = 1.47, 95% CI = 1.04-2.08) [18]. Due to these inconclusive results, as well as the publication of some additional studies, it was necessary to re-combine all of the articles, including 22 different case-control studies [15,16,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36], to conduct an updated meta-analysis.…”

“…meta-analysis(Table 1,Fig. 1)[15,16,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]. Of the 22 studies, TNF-α rs1800629 was analyzed in 22 studies; rs361525, in 8 studies; rs1799724, in 5 studies; and rs1799964, in 3 studies.…”