Association of smoking with liver fibrosis and mortality in primary biliary cholangitis

Mantaka, Aikaterini; Koulentaki, Mairi; Samonakis, Dimitrios; Sifaki-Pistolla, Dimitra; Voumvouraki, Argyro; Tzardi, Maria

doi:10.1097/meg.0000000000001234

Cited by 17 publications

(14 citation statements)

References 51 publications

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“…Considering the changing trends in liver disease etiology in the current metabolic-era, new studies on larger patients' series should be performed. Regarding PBC etiology, mortality is increased in smokers with advanced disease (bridging fibrosis and cirrhosis) at presentation [124]. Collectively, this data strongly suggest that smoking negatively impacts the outcome of patients with J o u r n a l P r e -p r o o f advanced chronic liver disease including cirrhosis and HCC, further reinforcing the need to identify and treat this significant lifestyle factor.…”

Section: Impact Of Smoking On Clinical Outcomes In Liver Disease Pati...mentioning

confidence: 84%

Cigarette smoking and liver diseases

Martí-Aguado

Clemente‐Sánchez

Bataller

2022

Journal of Hepatology

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Section: Impact Of Smoking On Clinical Outcomes In Liver Disease Pati...mentioning

confidence: 84%

Cigarette smoking and liver diseases

Martí-Aguado

Clemente‐Sánchez

Bataller

2022

Journal of Hepatology

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“…The risk of death from these conditions increases with increasing exposure to cigarette smoking, as measured by the number of cigarettes smoked daily and the duration of smoking (10). There is also growing evidence that cigarette smoking has negative association with the prognosis of chronic liver diseases (11)(12)(13)(14)(15)(16). Cigarette smoking was demonstrated to be associated with a dose-dependent relationship with the stage of liver fibrosis in patients with NAFLD via its effect on insulin resistance (11).…”

Section: Introductionmentioning

confidence: 99%

Cigarette Smoking Increased Risk of Overall Mortality in Patients With Non-alcoholic Fatty Liver Disease: A Nationwide Population-Based Cohort Study

Charatcharoenwitthaya

Karaketklang

Aekplakorn

2020

Front. Med.

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Background: The evidence suggests a detrimental effect of cigarette smoking on the progression of chronic liver disease. However, the impact of cigarette smoking on mortality among patients with non-alcoholic fatty liver disease (NAFLD) remain unclear.Methods: We used the National Health Examination Survey data collected during 2008–2009 to link the National Death Index to follow-up respondent survival. Diagnosis of NAFLD was based on a lipid accumulation product in participants without significant alcohol use or other liver diseases.Results: During 64,116 person-years of follow-up, 928 of 7,529 participants with NAFLD died, and the cumulative all-cause mortality was 14.5 per 1,000 person-years. In a Cox regression model adjusted for age, body mass index, alcohol intake, exercise, comorbidities, lipid profiles, and handgrip strength, current smoking increased the risk of mortality by 109% (adjusted hazard ratio (aHR): 2.09, 95% confidence interval [CI]: 1.18–3.71) compared with never smoker status in women, but showed only a trend toward harm among men (aHR: 1.41, 95% CI: 0.96–2.08). After controlling for potential confounders, smoking ≥10 pack-years continued to show a significant harmful effect on all-cause mortality among women (aHR: 5.40, 95% CI: 2.19–13.4), but not in men. Among women who drink alcohol ≥10 grams per day, current smoking (aHR: 13.8, 95% CI: 1.66–145) and smoking ≥10 pack-years (aHR: 310, 95% CI: 78–1,296) also significantly increased risk of death.Conclusion: This nationwide population-based study highlight a detrimental effect of cigarette smoking on mortality, with a similar but more definite association in women than in men with NAFLD.

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“…Based on these results, it could be argued that smokers may be more prone to liver injury and dysfunction, as smoking has been proposed to contribute to early liver disease onset and advanced liver fibrosis (Jung et al, 2019;Mantaka et al, 2018;Okamoto et al, 2018). After adjusting for smoking as a confounder, only the acrylamide metabolite (AAMA) demonstrated a positive association with serum ALP, suggesting that the AAMA effect potentially came from non-tobacco smoke sources such as heated foods (Semla et al, 2017).…”

Section: Discussionmentioning

confidence: 98%

Associations between residential exposure to volatile organic compounds (VOCs) and liver injury markers

Wahlang

Gripshover

Gao

et al. 2021

Preprint

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Occupational exposures to volatile organic compounds (VOCs) have been associated with numerous health complications including steatohepatitis and liver cancer. However, the potential impact of environmental/residential VOC exposures on liver health and function is largely unknown. To address this knowledge gap, the objective of this cross-sectional study is to investigate associations between VOCs and liver injury biomarkers in community residents. Subjects were recruited from six Louisville neighborhoods, and informed consent was obtained. Exposure biomarkers included 16 creatinine-adjusted urinary metabolites corresponding to 12 parent VOCs. Serological disease biomarkers measured included cytokertain-18 (K18 M65 and M30), liver enzymes and direct bilirubin. Associations between exposure and disease biomarkers were assessed using generalized linear models. Smoking status was confirmed through urinary cotinine levels. The population comprised of approximately 60% females and 40% males; White persons accounted 78% of the population; with more nonsmokers (n=413) than smokers (n=250). When compared to nonsmokers, Males (45%) and Black persons (26%) were more likely to be smokers. In the overall population, metabolites of acrolein, acrylonitrile, acrylamide, 1,3-butadiene, crotonaldehyde, styrene and xylene were positively associated with alkaline phosphatase (ALP). These associations persisted in smokers, with the exception of crotonaldehyde, and addition of N,N dimethylformamide and propylene oxide metabolites. Although no positive associations were observed for K18 M30, the benzene metabolite was positively associated with bilirubin, irrespective of smoking status. Taken together, the results demonstrated that selected VOCs were positively associated with liver injury biomarkers. These findings will enable better risk assessment and identification of populations vulnerable to liver disease.

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Association of smoking with liver fibrosis and mortality in primary biliary cholangitis

Abstract: There is an association between smoking, whether active or passive, and advanced fibrosis in PBC. Mortality is increased in smokers with advanced disease at presentation.

Cited by 17 publications

References 51 publications

Cigarette smoking and liver diseases

Cigarette smoking and liver diseases

Cigarette Smoking Increased Risk of Overall Mortality in Patients With Non-alcoholic Fatty Liver Disease: A Nationwide Population-Based Cohort Study

Associations between residential exposure to volatile organic compounds (VOCs) and liver injury markers

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