Association of Sleep Time With Diabetes Mellitus and Impaired Glucose Tolerance

Gottlieb, Daniel J.; Punjabi, Naresh M.; Newman, Anne B.; Resnick, Helaine E.; Redline, Susan; Baldwin, Carol M.; Nieto, F. Javier

doi:10.1001/archinte.165.8.863

Cited by 788 publications

(607 citation statements)

References 36 publications

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“…The association of short sleep duration and diabetes has been recently reported in several studies, more consistently among male adults. Short sleep duration was related to diabetes in the Massachusetts Male Aging Study [3] and in both men and women in the cross-sectional analysis of the Sleep Heart Health Study [11]. However, in a Swedish study, increased incidence of diabetes related to short sleep duration was found in men but not in women.…”

Section: Discussionmentioning

confidence: 87%

“…First, we did not include obstructive sleep apnea (OSA). However, OSA was not correlated with sleep duration, and the effect of short or long sleep duration was observed regardless of OSA symptoms [11]. Second, this study was cross-sectional.…”

Section: Sleep Duration Amentioning

confidence: 83%

“…This association was not found in female adults in the Nurse Health Study [5] and in the KNHANES III (data not shown), either. Long sleep duration has also been associated with diabetes [2,3,5,11], but this association is thought to be mediated by confounding factors [2,3,5].…”

Section: Discussionmentioning

confidence: 99%

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The association of sleep duration and type 2 diabetes in Korean male adults with abdominal obesity: The Korean National Health and Nutrition Examination Survey 2005

Kim

et al. 2009

Diabetes Research and Clinical Practice

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Section: Discussionmentioning

confidence: 87%

Section: Sleep Duration Amentioning

confidence: 83%

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The association of sleep duration and type 2 diabetes in Korean male adults with abdominal obesity: The Korean National Health and Nutrition Examination Survey 2005

Kim

et al. 2009

Diabetes Research and Clinical Practice

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“…In humans, melatonin administration reduced glucose tolerance mainly by decreasing insulin release at the time of morning while decline in insulin sensitivity was observed in the evening (87). In addition, various studies established a correlation between sleep disorders and a greater risk for a decreased glucose tolerance and type 2 diabetes (88)(89)(90). The existence of an association between glucose and time keeping mechanism has been proved by the alteration of 24 h rhythmic expression of clock genes as a result of high fat diet intake in rats (91).…”

Section: Melatonin and Diabetesmentioning

confidence: 99%

The role of melatonin in diabetes: therapeutic implications

Sharma

Singh

Ahmad

et al. 2015

Arch. Endocrinol. Metab.

106

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Melatonin referred as the hormone of darkness is mainly secreted by pineal gland, its levels being elevated during night and low during the day. The effects of melatonin on insulin secretion are mediated through the melatonin receptors (MT1 and MT2). It decreases insulin secretion by inhibiting cAMP and cGMP pathways but activates the phospholipaseC/IP3 pathway, which mobilizes Ca 2+ from organelles and, consequently increases insulin secretion. Both in vivo and in vitro, insulin secretion by the pancreatic islets in a circadian manner, is due to the melatonin action on the melatonin receptors inducing a phase shift in the cells. Melatonin may be involved in the genesis of diabetes as a reduction in melatonin levels and a functional interrelationship between melatonin and insulin was observed in diabetic patients. Evidences from experimental studies proved that melatonin induces production of insulin growth factor and promotes insulin receptor tyrosine phosphorylation. The disturbance of internal circadian system induces glucose intolerance and insulin resistance, which could be restored by melatonin supplementation. Therefore, the presence of melatonin receptors on human pancreatic islets may have an impact on pharmacotherapy of type 2 diabetes. Arch Endocrinol Metab.2015;59(5):391-9

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“…Habitual short sleep duration is also associated with a host of chronic health conditions such as hypertension, diabetes, depression, obesity, certain cancers, and increased mortality (4)(5)(6)(7)(8)(9). On the other hand, long sleep duration has also been associated with chronic health problems such as obesity, diabetes, heart disease, and stroke (10)(11)(12)(13)(14)(15)(16). In fact, in several studies, the association between long sleep duration and health problems is even stronger than that found with short sleep duration (12,17,18).…”

mentioning

confidence: 99%

Sleep Duration and Metabolic Syndrome. An Updated Dose–Risk Metaanalysis

et al. 2015

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Rationale: Several studies have reported that both short and long sleep durations are associated with the metabolic syndrome, but whether a dose-response relationship exists is unclear.Objectives: We performed a metaanalysis to study the magnitude of the association between the different durations of sleep and metabolic syndrome. Methods:We searched in the databases of PubMed, Web of Science, and Ovid (all Journals@Ovid) from inception to October 4, 2014 for cross-sectional studies where an association between metabolic syndrome and sleep duration was analyzed. Measurements and Main Results:Eighteen studies with 75,657 participants were included. Daily sleep duration of 7 to 8 hours was used as the reference group. The odds ratio (OR) of having metabolic syndrome for short (,7 h) sleep was 1.23 (95% CI, 1.11-1.37; P , 0.001; I 2 , 71%). The ORs for less than 5 hours, 5 to 6 hours, and 6 to 7 hours of sleep were 1.51 (95% CI, 1.10-2.08; P = 0.01), 1.28 (95% CI, 1.11-1.48; P , 0.001), and 1.16 (95% CI, 1.02-1.31; P = 0.02), respectively. The coefficient of sleep duration on log of ORs was 20.06 6 0.02 (P = 0.02). The OR for long sleep duration was 1.13 (95% CI, 0.97-1.32; P = 0.10; I 2 , 89%).Conclusions: A dose-response relationship exists between short sleep duration and metabolic syndrome. Those who report a sleep duration of less than 5 hours have a 1.5 higher odds of having metabolic syndrome. Our study does not support the notion that long sleep is associated with metabolic syndrome.

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Association of Sleep Time With Diabetes Mellitus and Impaired Glucose Tolerance

Abstract: A sleep duration of 6 hours or less or 9 hours or more is associated with increased prevalence of DM and IGT. Because this effect was present in subjects without insomnia, voluntary sleep restriction may contribute to the large public health burden of DM.

Cited by 788 publications

References 36 publications

The association of sleep duration and type 2 diabetes in Korean male adults with abdominal obesity: The Korean National Health and Nutrition Examination Survey 2005

The association of sleep duration and type 2 diabetes in Korean male adults with abdominal obesity: The Korean National Health and Nutrition Examination Survey 2005

The role of melatonin in diabetes: therapeutic implications

Sleep Duration and Metabolic Syndrome. An Updated Dose–Risk Metaanalysis

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