Association of Skin and Cartilage Variables With Composite Graft Healing in a Rabbit Model

Lu, G. Nina; Tawfik, Ossama; Sykes, Kevin J.; Kriet, J. David; Durham, Dianne; Humphrey, Clinton D.

doi:10.1001/jamafacial.2018.1044

Cited by 2 publications

(3 citation statements)

References 20 publications

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“…1,2,5,12 Although it is true that composite grafts require a high metabolic demand due to the bridging phenomenon whereby vascularization occurs from direct anastomoses between the subdermal plexus of the wound edges and subdermal plexus of the graft, 1,12 recently, a study in mouse models demonstrated evidence that maintaining the skin-to-perichondrium junction in a 1:1 ratio has a significant association with cartilage graft survival. 13 The authors recommended that surgeons preserve the chondrocutaneous junction for optimal cartilage graft viability. 13 As the results of Haas and Glogau are frequently quoted in textbooks, it should be noted that in their design, the graft is folded in half, creating a "fat sandwich," which significantly differs from the composite graft described here.…”

Section: Discussionmentioning

confidence: 99%

“…13 The authors recommended that surgeons preserve the chondrocutaneous junction for optimal cartilage graft viability. 13 As the results of Haas and Glogau are frequently quoted in textbooks, it should be noted that in their design, the graft is folded in half, creating a "fat sandwich," which significantly differs from the composite graft described here. In addition, once transplanted, fat grafts are known to undergo fatty involution, thus minimizing volume required in deep alar wounds.…”

Section: Discussionmentioning

confidence: 99%

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Superior Antihelix Composite Graft for Repair of Nasal Ala and Lateral Nasal Tip Defects: A Retrospective Case Series

Riopelle

Jeong

Kaliszewski

et al. 2023

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BACKGROUNDDeep defects on the nasal ala and lateral nasal tip may result in nasal valve insufficiency or alar notching and are often repaired with a 2-stage reconstruction. Previous literature has demonstrated high failure rates of composite grafts.OBJECTIVEIdentify survival rates and cosmetic outcomes of nasal composite grafts harvested from the antihelix.METHODSA retrospective review of 52 patients who underwent ala or lateral nasal tip composite graft repair from April 2019 through May 2022, with statistical analysis of cosmetic outcomes graded by 2 surgeons.RESULTSDefect size ranged from 0.7 cm × 0.8 cm to 1.9 cm × 2.5 cm. 48 grafts survived (92.3% survival rate). Four patients sustained at least partial integument sloughing (epidermal necrosis), but the cartilage survived in all 52 cases. Overall, aesthetic results yielded the following: excellent (19.5%), very good (35.5%), good (11.5%), decent (16.5%), and poor (6%). In 93% of cases, there was no evidence of nasal collapse or retraction. Two patients (3.8%) required surgical revision. Donor site morbidity was low.CONCLUSIONThe antihelical composite skin graft is a 1-step reliable repair option for ala and lateral nasal tip defects with an acceptable cosmetic outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Superior Antihelix Composite Graft for Repair of Nasal Ala and Lateral Nasal Tip Defects: A Retrospective Case Series

Riopelle

Jeong

Kaliszewski

et al. 2023

View full text Add to dashboard Cite

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“…The changes that have occurred in the human body after cartilage transplantation and the process of absorption and regeneration after autologous cartilage transplantation have always been the focus of clinical work. In recent years, scholars’ experiments and reports on cartilage transplantation and outcomes mainly focus on issues, such as whether there are growth or changes in volume or morphology after cartilage transplantation, which mostly used small animals as models to carry out 3 to 6 months of research 16,17. However, there is still a lack of relevant research reports on the long-term outcome after cartilage transplantation in clinical practical applications.…”

Section: Discussionmentioning

confidence: 99%

Experimental Study on the Biological Outcome of Auricular Cartilage and Costal Cartilage at Different Time Periods After Autologous Cartilage Rhinoplasty

Sun

Sheng

et al. 2022

Journal of Craniofacial Surgery

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Since autologous cartilage is a good transplant material, it is widely used in various fields of clinical medicine. In this study, we collected clinical specimens obtained at different numbers of years after transplantation and used histologic staining to explore the post-transplantation changes in auricular cartilage and costal cartilage. A retrospective analysis was performed on patients who underwent primary autologous cartilage rhinoplasty and secondary rhinoplasty from 2017 to 2021, and the remaining autologous cartilage tissue after surgery was used for histologic testing. As time progressed after transplantation, the density of costal chondrocytes decreased first and then increased, while the secretion of type II collagen and extracellular matrix both decreased slightly. There was a clear boundary between the cartilage tissue and the surrounding connective tissue, and there was no ingrowth of blood vessels in the cartilage. Auricular cartilage showed a decrease in the integrity of the matrix edge. Moreover, local fibrosis was visible, and vascular ingrowth was observed at the edge of the cartilage. The content of type II collagen first increased and then decreased, and the cell secretion function was lower than that of normal chondrocytes. The results of the study suggest that the histologic outcome of elastic cartilage after transplantation is significantly different from that of hyaline cartilage. Moreover, costal cartilage was more stable than auricular cartilage after transplantation.

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Association of Skin and Cartilage Variables With Composite Graft Healing in a Rabbit Model

Cited by 2 publications

References 20 publications

Superior Antihelix Composite Graft for Repair of Nasal Ala and Lateral Nasal Tip Defects: A Retrospective Case Series

Superior Antihelix Composite Graft for Repair of Nasal Ala and Lateral Nasal Tip Defects: A Retrospective Case Series

Experimental Study on the Biological Outcome of Auricular Cartilage and Costal Cartilage at Different Time Periods After Autologous Cartilage Rhinoplasty

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