Association of Single Nucleotide Polymorphisms in<i>TNFA</i>and<i>IL10</i>Genes with Disease Severity in Influenza A/H1N1pdm09 Virus Infections: A Study from Western India

Choudhary, Manohar Lal; Alagarasu, Kalichamy; Chaudhary, Urmila; Kawale, Samruddhi; Malasane, Prachi; Gurav, Yogesh K.; Padbidri, Vikram; Kadam, Deelip; Sangle, Shashikala; Salvi, Sonali; Bavdekar, Ashish; D'Costa, Pradeep; Chadha, Mandeep S.

doi:10.1089/vim.2018.0120

Cited by 13 publications

(12 citation statements)

References 25 publications

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“…In this regard, some studies suggested that SNPs in the IL-10 and IL-1β genes might be associated with the severe outcome in influenza outbreak [39, 40]. Also, another study demonstrated that polymorphisms of L-1β, IL-10, IL-17, and IL-28 genes involved in the inflammatory process affect the outcome of disease caused by influenza A/H3N2 virus [33].…”

Section: Discussionmentioning

confidence: 99%

Association of polymorphisms in inflammatory cytokines encoding genes with severe cases of influenza A/H1N1 and B in an Iranian population

Keshavarz

Namdari

Farahmand

et al. 2019

Virol J

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Background The increased levels of blood cytokines is the main immunopathological process that were attributed to severe clinical outcomes in cases of influenza A, influenza B and people with influenza-like illness (ILI). Functional genetic polymorphisms caused by single nucleotide polymorphisms (SNPs) in inflammatory cytokines genes can influence their functions either qualitatively or quantitatively, which is associated with the possibility of severe influenza infections. The aim of the present case-control study was to investigate the association of polymorphisms in inflammatory cytokines genes with influenza patients and ILI group in an Iranian population. Methods Total number of 30 influenza B, 50 influenza A (H1N1) and 96 ILI inpatient individuals were confirmed by Real-time RT-PCR and HI assays. The genotype determination was assessed for defined SNPs in IL-1β, IL-17, IL-10 and IL-28 genes. Results The frequencies of the IL-1β rs16944 ( P = 0.007 ) and IL-17 rs2275913 ( P = 0.006 ) genotypes were associated with severe influenza disease, while the frequencies of IL-10 rs1800872 and IL-28 rs8099917 were not associated with the disease ( P > 0.05 ). Also, the absence of A allele in IL-17 rs2275913 SNP increased the risk of influenza A (H1N1) infection ( P = 0.008 ). Conclusions This study demonstrated that influenza A- (H1N1) and B-infected patients and also ILI controls have different profiles of immune parameters, and individuals carrying the specific cytokine-derived polymorphisms may show different immune responses towards severe outcome.

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Section: Discussionmentioning

confidence: 99%

Association of polymorphisms in inflammatory cytokines encoding genes with severe cases of influenza A/H1N1 and B in an Iranian population

Keshavarz

Namdari

Farahmand

et al. 2019

Virol J

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“…The ULK1 complex initiates autophagosome formation, linking cellular nutrient status to downstream events in autophagy [43]. An earlier study suggested that SNPs in the IL10 gene might be associated with disease severity in influenza A(H1N1)pdm09 infected patients [44]. BST2 protein has been described to inhibit the virus replication by tethering the virus release from the cell surface [45] or by inducing the NF-κB dependent antiviral immune response [46] or by targeting and degrading virus nucleocapsid protein [47].…”

Section: Discussionmentioning

confidence: 99%

A host-based whole genome sequencing study reveals novel risk loci associated with severity of influenza A(H1N1)pdm09 infection

Chen

et al. 2021

Emerging Microbes & Infections

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Influenza A(H1N1)pdm09 virus has remained in a seasonal circulation since being recognized in 2009. Although it followed a mild course in most patients, in others it caused a series of severe clinical illnesses. Epidemiologic studies have implicated that host factors have a major influence on the disease severity of influenza A(H1N1)pdm09 infection. However, an understanding of relevant genetic variations and the underlying mechanisms is still limited. In this present study, we used a host-based whole genome sequencing (WGS) method to comprehensively explore the genetic risk loci associated with severity of influenza A(H1N1)pdm09 infection. From the common single-nucleotide variants (SNVs) analysis, we identified the abnormal nominally significant ( P < 1 × 10 −4 ) common SNVs enriched in PTBP3 gene. The results of rare functional SNVs analysis supported that there were several novel candidate genes might confer risk of severe influenza A(H1N1)pdm09 diseases, such as FTSJ3 , CPVL , BST2 , NOD2 and MAVS . Moreover, our results of gene set based analysis indicated that the HIF-1 transcription factor and IFN-γ pathway might play an important role in the underlying mechanism of severe influenza A(H1N1)pdm09. These findings will increase our knowledge about biological mechanism underlying the severe influenza A(H1N1)pdm09 and facilitate to design novel personalized treatments.

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“…Early studies have shown that IL-1β, IL-10, IL-17 and IL-28 gene polymorphisms are associated with the inflammatory process affecting the outcome of influenza virus A/H3N2 infection (Keshavarz et al, 2019;Rogo et al, 2016). It was observed that in a dominant mode, IL-10 rs1800896 G allele was significantly negatively associated with disease severity during H1N1 pandemic (Choudhary et al, 2018). Hence, there is enough evidence to speculate a varied response of cytokine gene polymorphism in COVID-19 patients of different ethnicities.…”

Section: Indian Scenariomentioning

confidence: 99%

COVID-19: Variable Immune Response in Indian Population

Das

Gupta

Akhter

et al. 2021

Egyptian Academic Journal of Biological Sciences. C, Physiology

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With a year and a half into the COVID-19 pandemic, still, variance in terms of transmission and susceptibility of different populations/ethnicities to the disease remains an enigma. The clinical outcome of COVID-19 disease is poor in patients with associated morbidities; however, the reasons behind significant mortality of immuno-competent healthy individuals attributed to fulminant infection remains to be elucidated. Generally, protective B and T cell-mediated immune responses seem to have a tilted balance causing a sustained inflammatory state in SARS-CoV-2 infected individuals. The genetic makeup of an individual is highly likely to play a major role in elicitation as well as the outcome of the immune response in COVID-19 cases. The Indian response to COVID-19 indicates a potential influence of genetic background on host immune response pathways leading to decreased susceptibility and mortality to SARS-CoV-2 infection. Many host genes are involved in the entry and replication of SARS-CoV-2 and the subsequent host immune response. The current review discusses the potential cytokine gene polymorphisms prevalent in the Indian population that may influence the transmission, severity and mortality due to COVID-19 infection.

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Association of Single Nucleotide Polymorphisms inTNFAandIL10Genes with Disease Severity in Influenza A/H1N1pdm09 Virus Infections: A Study from Western India

Cited by 13 publications

References 25 publications

Association of polymorphisms in inflammatory cytokines encoding genes with severe cases of influenza A/H1N1 and B in an Iranian population

Association of polymorphisms in inflammatory cytokines encoding genes with severe cases of influenza A/H1N1 and B in an Iranian population

A host-based whole genome sequencing study reveals novel risk loci associated with severity of influenza A(H1N1)pdm09 infection

COVID-19: Variable Immune Response in Indian Population

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