Association of sex with the global burden of glaucoma: an analysis from the global burden of disease study 2017

Ye, Xin; She, Xiangjun; Shen, Lijun

doi:10.1111/aos.14330

Cited by 13 publications

(16 citation statements)

References 28 publications

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“…This may be due to the longer life expectancy of females. Males had higher DALYs rate of glaucoma than females which is consistent with the global analysis by Zhang 11 and Ye 17 but inconsistent with the analysis by Wang. 10 Above all, the rapidly increasing DALYs rate as shown in Figure 3 necessitates the development of new methods for glaucoma screening and diagnosis.…”

Section: Discussionmentioning

confidence: 43%

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Disease Burden of Glaucoma in China: Findings from the Global Burden of Disease 2019 Study

Sun¹,

Chen²,

Zou³

et al. 2022

CLEP

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To provide evidence for future strategies in preventing glaucomatous blindness by investigating the disease burden in terms of age, year, and gender from 1990 to 2019 in China. Methods: The prevalence and disability-adjusted life years (DALYs) of blindness and vision loss due to glaucoma in China were extracted from the Global Burden of Disease (GBD) 2019 study. Age-standardized data is presented in comparison to China's neighboring countries. Results: From 1990 to 2019, the prevalent cases and DALYs number with glaucomatous blindness and vision loss increased by 129.53% and 67.29%, respectively. Overall, higher age-standardized prevalence and DALYs rate were detected in males than in females between 1990 and 2019, and people aged 60 to 89 years suffered from a higher DALY number than other age groups in 2019.

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Section: Discussionmentioning

confidence: 43%

“…18 On the contrary, Ye revealed that the age-standardized DALY rates decreased consistently from 10.7 in 1990 to 9.4 in 2017 among men and from 8.8 in 1990 to 8.0 in 2017 among women. 17 We give several potential reasons for the variation. First, the strategies for the prevention and control of glaucoma were different among regions.…”

Section: Discussionmentioning

confidence: 99%

Disease Burden of Glaucoma in China: Findings from the Global Burden of Disease 2019 Study

Sun¹,

Chen²,

Zou³

et al. 2022

CLEP

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“…A larger epidemiological and genetic study in individuals of different ancestries will clarify the role of GWAS signals identified here or other additional signals in differential risk burden between ancestries and genders, distinct from what has been reported globally. 153 We further performed extensive in-silico validation of the SIX6 and CDKN2B-AS1 loci, using GTEx and EHR data across BioVU and UKBB. In our study we found evidence of significant interaction between SIX6 rs33912345 and causal variants in chr9p21.3, with concomitant effect on expression of a primary cilia gene CDKN2A, and CDKN2B in the CDKN2B-AS1 locus.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Genome-wide association meta-analysis identifies novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation

Faro

Bhattacharya

Zhou

et al. 2021

Preprint

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Primary open-angle glaucoma (POAG) is a complex eye disease characterized by progressive loss of optic nerve function that, if untreated, ultimately leads to irreversible blindness. To date, the biological mechanisms causing POAG are still unclear. There is disparity in POAG prevalence, clinical presentations and outcomes across ancestries. Here, we aim to identify unique genetics that underlie risk to POAG and evaluate the potential connection with vascular mechanisms. We performed POAG meta-analysis across 15 biobanks that are part of the Global Biobank Meta-analysis Initiative, with two previously published multi-ancestry analyses for a total of 1,478,037 individuals from six ancestries (46,325 cases and 1,431,712 controls). A total of 109 genome-wide significantly associated loci (p<5e-8) were identified, 18 of which were novel. Three of these novel loci are ancestry-specific, two African-specific and the third specific to northern Europeans. We also identified five sex-specific novel loci, four of which are African-specific and one European-specific. To explore biological implications underlying these variant-trait associations, we performed gene enrichment analysis, gene prioritization analysis and transcriptome-wide association studies (TWAS) implicating genes related to vascular-related functions, blood vessels, angiogenesis, and cancer. A fifth of TWAS-prioritized genes with vascular-related and/or cell senescence/proliferation functional roles or have been implicated in vascular or neoplastic diseases are primary ciliary related genes. We further performed extensive statistical validation analysis of genes in the SIX6 and well-known CDKN2B-AS1 loci, previously implicated in POAG, cardiovascular diseases, and cancers across multiple ancestries. We found evidence of significant interaction between SIX6 rs33912345 and causal variants in chr9p21.3, with concomitant effect on expression of a primary cilia gene CDKN2A and CDKN2B at the CDKN2B-AS1 locus. Phenome-wide association analysis of POAG genetic risk burden across five biobanks and genetic correlation analysis also show the shared biology between POAG and vascular and neoplastic traits. In summary, our findings suggest that some POAG risk variants may be ancestry-specific, sex-specific, or both. Our findings further support the contribution of vascular and proliferation genes in POAG and suggest potential involvement of primary cilia in POAG pathogenesis.

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“…Females are known to have higher rates of blindness globally 38 even when controlling for socioeconomic status 39 . Unequal access to eye care services according to socioeconomic status (such as income and education levels) and by socio-cultural status (for example by gender) was considered a factor for visually impaired people, particularly in low income countries 38,40 . At the same time, gender difference associated with visual impairment and health status remains controversial 41,42 .…”

Section: Discussionmentioning

confidence: 99%

Socioeconomic and physical health status changes after visual impairment in Korea using difference-in-difference estimations

Kim

Koo

Han

2021

Sci Rep

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This study analyzed the impact of visual impairment on socioeconomic and physical health status and its heterogeneity by severity of visual impairment. We used nationally representative cohort data based on Korean national health insurance claims (2002–2013), which were extracted for 11,030 persons (2206 visually impaired, 8824 control). This was restructured as monthly data for each person (person-month). Multivariate and ordered logistic regressions were conducted, and the pre-impairment status between the visually impaired and non-visually impaired people was adjusted by difference-in-difference (DiD) estimation. Focusing on medical aid (a public healthcare service assistance program for people who cannot afford health insurance premiums), the DiD estimate showed that the likelihood of receiving aid was higher among visually impaired compared with non-impaired people. Mildly and severely visually impaired people were more likely to be medical aid recipients than their counterparts. The severely visually impaired group was more likely to be unemployed. The visually impaired group were less likely to have no comorbidity. Our findings show that the socioeconomic and physical health status of visually impaired people is more likely to deteriorate than that of their non-visually impaired counterparts following onset of impairment.

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Association of sex with the global burden of glaucoma: an analysis from the global burden of disease study 2017

Cited by 13 publications

References 28 publications

Disease Burden of Glaucoma in China: Findings from the Global Burden of Disease 2019 Study

Disease Burden of Glaucoma in China: Findings from the Global Burden of Disease 2019 Study

Genome-wide association meta-analysis identifies novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation

Socioeconomic and physical health status changes after visual impairment in Korea using difference-in-difference estimations

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