Association of Sex Hormones With Sexual Function, Vitality, and Physical Function of Symptomatic Older Men With Low Testosterone Levels at Baseline in the Testosterone Trials

Cunningham, Glenn R.; Stephens‐Shields, Alisa J.; Rosen, Raymond C.; Wang, Christina; Ellenberg, Susan S.; Matsumoto, Alvin M.; Bhasin, Shalender; Molitch, Mark E.; Farrar, John T.; Cella, David; Barrett‐Connor, Elizabeth; Cauley, Jane A.; Cifelli, Denise; Crandall, Jill P.; Ensrud, Kristine E.; Fluharty, Laura; Gill, Thomas M.; Lewis, Cora E.; Pahor, Marco; Resnick, Susan M.; Storer, Thomas W.; Swerdloff, Ronald S.; Anton, Stephen D.; Basaria, Shehzad; Diem, Susan J.; Tabatabaie, Vafa; Hou, Xiaoling; Snyder, Peter J.

doi:10.1210/jc.2014-3818

Cited by 81 publications

(46 citation statements)

References 39 publications

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“…The association observed here between estradiol levels and self-rated health is stronger than that observed (and widely recognized) between testosterone levels and measures of sexual desire and activity (31) and is similar to that which we have reported previously between circulating estrone levels and the risk of incident diabetes mellitus (30). With each 50% between-person difference in circulating estradiol level-comparable with the withinindividual change that might attend aging from a 20-year old to a middle-aged man (17)-we observed that the odds of reporting "fair or poor" self-rated health would be increased by 1.78, indicating the potential for nontrivial implications for self-rated health of increases in male estrogen levels with aging.…”

Section: Discussioncontrasting

confidence: 84%

Circulating Estrogen Levels and Self-Reported Health and Mobility Limitation in Community-Dwelling Men of the Framingham Heart Study

Jasuja

Travison

Murabito

et al. 2016

GERONA

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Background: Self-rated health is a commonly used global indicator of health status. Few studies have examined the association of self-rated health and mobility with estrone and estradiol in men. Accordingly, we determined the cross-sectional, incident, and mediating relations between circulating estrone and estradiol levels with self-rated health, mobility limitation, and physical performance in community-dwelling men. Methods:The cross-sectional sample included 1,148 men, who attended Framingham Offspring Study Examinations 7 and 8. Estrone and estradiol levels were measured using liquid chromatography tandem mass spectrometry at Examination 7. Self-reported mobility limitation and self-rated health were assessed at Examinations 7 and 8. Additionally, short physical performance battery, usual walking speed, and grip strength were assessed at Examination 7. Results: In incident analysis, estradiol levels at Examination 7 were associated with increased odds of fair or poor self-rated health at Examination 8, after adjusting for age, body mass index, comorbidities, and testosterone levels; in an individual with 50% greater estradiol than other, the odds of reporting "fair or poor" self-rated health increased by 1.78 (95% confidence interval: 1.25-2.55; p = .001). Neither estrone nor estradiol levels were associated with any physical performance measure at baseline. Conclusions: Higher circulating levels of estradiol are associated with increased risk of incident fair/poor self-rated health in communitydwelling men. The mechanisms by which circulating levels of estradiol are related to self-rated health in men need further investigation.

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Section: Discussioncontrasting

confidence: 84%

Circulating Estrogen Levels and Self-Reported Health and Mobility Limitation in Community-Dwelling Men of the Framingham Heart Study

Jasuja

Travison

Murabito

et al. 2016

GERONA

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“…10 Sexual symptoms and fatigue are the earliest and most common presentations. 11 Other symptoms (e.g., depression, sleep alterations, poor concentration) and metabolic disorders (e.g., type 2 diabetes mellitus, obesity) are seen at borderline testosterone levels.…”

Section: Diagnosismentioning

confidence: 99%

Diagnosis and management of testosterone deficiency syndrome in men: clinical practice guideline

Morales

Bebb

Manjoo

et al. 2015

CMAJ

196

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“…Note that some observational studies have reported that TRT increases cardiovascular events in patients with metabolic syndrome (119). However, the Food and Drug Administration in the US has reviewed these reports and found them to be seriously flawed (22). Although the beneficial effects of TRT in diabetic men have been widely demonstrated in terms of metabolic parameters, whether they are accompanied by an improvement in kidney function in patients with renal complications remains unclear.…”

Section: Childhoodmentioning

confidence: 99%

RAS and sex differences in diabetic nephropathy

Clotet

Riera

Pascual

et al. 2016

American Journal of Physiology-Renal Physiology

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The incidence and progression of kidney diseases are influenced by sex. The renin-angiotensin system (RAS) is an important regulator of cardiovascular and renal function. Sex differences in the renal response to RAS blockade have been demonstrated. Circulating and renal RAS has been shown to be altered in type 1 and type 2 diabetes; this enzymatic cascade plays a critical role in the development of diabetic nephropathy (DN). Angiotensin converting enzyme (ACE) and ACE2 are differentially regulated depending on its localization within the diabetic kidney. Furthermore, clinical and experimental studies have shown that circulating levels of sex hormones are clearly modulated in the context of diabetes, suggesting that sex-dependent RAS regulation may be also be affected in these individuals. The effect of sex hormones on circulating and renal RAS may be involved in the sex differences observed in DN progression. In this paper we will review the influence of sex hormones on RAS expression and its relation to diabetic kidney disease. A better understanding of the sex dimorphism on RAS might provide a new approach for diabetic kidney disease treatment.

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Association of Sex Hormones With Sexual Function, Vitality, and Physical Function of Symptomatic Older Men With Low Testosterone Levels at Baseline in the Testosterone Trials

Cited by 81 publications

References 39 publications

Circulating Estrogen Levels and Self-Reported Health and Mobility Limitation in Community-Dwelling Men of the Framingham Heart Study

Circulating Estrogen Levels and Self-Reported Health and Mobility Limitation in Community-Dwelling Men of the Framingham Heart Study

Diagnosis and management of testosterone deficiency syndrome in men: clinical practice guideline

RAS and sex differences in diabetic nephropathy

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