Association of sex hormone-binding globulin with nonalcoholic fatty liver disease in Chinese adults

Luo, Jing; Chen, Qian; Shen, Tao; Wang, Xu; Fang, Wanjun; Wu, Xiaodi; Yuan, Zenan; Chen, Gengdong; Liu, Wenhua; Chen, Yuming

doi:10.1186/s12986-018-0313-8

Cited by 27 publications

(27 citation statements)

References 49 publications

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“…In addition, neither chain length nor saturation influenced substantially the relationship between long-chain FAs with SHBG or HNF4α mRNAs. These results extend the findings of Luo et al ( 29 ) and Sáez-Lopez et al ( 30 ), who reported that SHBG mRNA and protein levels correlate negatively with hepatic triglyceride content in patients with benign hepatic tumors or obese patients with NAFLD undergoing bariatric surgery, respectively, and suggest that down-stream signaling by increased hepatic fatty acids, rather than the fatty acid per se , is responsible for the low levels of SHBG in subjects with metabolic syndrome.…”

Section: Discussionsupporting

confidence: 89%

The hepatic lipidome and HNF4α and SHBG expression in human liver

Winters

Scoggins

Appiah

et al. 2020

Endocrine Connections

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Low plasma levels of sex hormone binding globulin (SHBG) are a marker for obesity, insulin resistance, non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes. The transcription factor HNF4α is a major determinant of hepatic SHBG expression and thereby serum SHBG levels, and mediates in part the association of low SHBG with hyperinsulinemia and hepatic steatosis. We analyzed the lipidome in human liver specimens from a cohort of patients who underwent hepatic resection as a treatment for cancer, providing insight into hepatic lipids in those without extreme obesity or the clinical diagnosis of NAFLD or non-alcoholic steatohepatitis. Both steatosis and high HOMA-IR were associated with higher levels of saturated and unsaturated FA, other than arachidonic, with the most dramatic rise in 18:1 oleate, consistent with increased stearoyl-Co A desaturase activity. Individuals with low HOMA-IR had low levels of total hepatic fatty acids while both low and high fatty acid levels characterized the high HOMA-IR group. Both insulin resistance and high levels of hepatic fat were associated with low expression levels of HNF4α and thereby SHBG, but expression of these genes was also low in the absence of these determinants, implying additional regulatory mechanisms that remain to be determined.

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Section: Discussionsupporting

confidence: 89%

The hepatic lipidome and HNF4α and SHBG expression in human liver

Winters

Scoggins

Appiah

et al. 2020

Endocrine Connections

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“…Height, weight, waist circumference, and hip circumference were measured twice with the participants standing and wearing light daily clothing, and the mean values were calculated. Body mass index (BMI) was calculated as weight (kg) divided by the height squared (m 2 ), and values greater than 24 kg/m 2 were identified as overweight [25]. The waist-to-hip ratio (WHR) was calculated as the waist circumference divided by the hip circumference.…”

Section: Clinical and Laboratory Assessmentmentioning

confidence: 99%

“…NAFLD was diagnosed by abdominal ultrasonography following the standard criteria issued by the Fatty Liver Disease Study Group of the Chinese Liver Disease Association [25,26]. The remission of NAFLD was defined as the presence of NAFLD at baseline and the absence at the follow-up.…”

Section: Evaluation Of Nafldmentioning

confidence: 99%

Inverse Association of Serum Adipsin with the Remission of Nonalcoholic Fatty-Liver Disease: A 3-Year Community-Based Cohort Study

Luo

Chen

et al. 2021

Ann Nutr Metab

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Purposes: Adipokine alterations contribute to the development and remission of nonalcoholic fatty-liver disease (NAFLD). Adipsin is one of the most abundant adipokines and is almost exclusively produced by adipocytes. However, data on adipsin in human NAFLD are limited and controversial. We performed this study to investigate the association between adipsin and the remission of NAFLD in middle-aged and elderly Chinese adults. Methods: Whether adipsin is associated with the remission of NAFLD in a 3-year community-based prospective cohort study was investigated. Baseline levels of adipsin were measured in serum samples collected from 908 NAFLD participants. NAFLD was diagnosed using abdominal ultrasonography. Logistic regression analysis and a multiple stepwise logistic regression model including different variables were conducted to evaluate the association between serum adipsin levels and the remission of NAFLD. Results: During a mean follow-up of 3.14 ± 0.36 years, 247 (27.20%) participants with NAFLD at baseline were in remission. At baseline, serum adipsin concentration was positively correlated with body mass index (r: 0.39, p < 0.001), insulin (r: 0.31, p < 0.001), and homeostasis model assessment of insulin resistance (r: 0.31, p < 0.001) and was inversely associated with NAFLD remission with a fully adjusted odds ratio (OR) of 0.28 (0.16–0.48) (p trend < 0.001). In a multiple stepwise logistic regression model, circulating adipsin independently predicted NAFLD remission (OR: 0.284, 95% confidence interval [CI]: 0.172–0.471, p for trend <0.001). The area under the receiver operating characteristic curve was 0.751 (95% CI: 0.717–0.785) (p < 0.001) for the prediction model of NAFLD remission. Conclusions: We provide evidence for an association between serum adipsin levels and the remission of NAFLD in a community-based prospective cohort study. Serum adipsin can be a potential biomarker for predicting NAFLD remission.

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“…[57,58] The SHBG level in the liver and peripheral was significantly lower in patients with hepatic steatosis, where serum SHBG was found to be negatively associated with insulin resistance and hyperinsulinemia. [59,60] SHBG level was also shown to be significantly lower in menopausal women patients with NAFLD verified by liver biopsy. After the normalization of age, waistline and BMI, SHBG was an independent risk factor for NAFLD.…”

Section: Sex Hormone-binding Globulinmentioning

confidence: 86%

Role of hepatokines in non-alcoholic fatty liver disease

Lin

et al. 2019

Journal of Translational Internal Medicine

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Non-alcoholic fatty liver disease (NAFLD) is closely associated with metabolic diseases like type 2 diabetes and obesity. In recent decades, accumulating evidence has revealed that the hepatokines, proteins mainly secreted by the liver, play important roles in the development of NAFLD by acting directly on the lipid and glucose metabolism. As a member of organokines, the hepatokines establish the communication between the liver and the adipose, muscular tissues. In this review, we summarize the current understanding of the hepatokines and how they modulate the pathogenesis of metabolic disorders especially NAFLD.

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Association of sex hormone-binding globulin with nonalcoholic fatty liver disease in Chinese adults

Cited by 27 publications

References 49 publications

The hepatic lipidome and HNF4α and SHBG expression in human liver

The hepatic lipidome and HNF4α and SHBG expression in human liver

Inverse Association of Serum Adipsin with the Remission of Nonalcoholic Fatty-Liver Disease: A 3-Year Community-Based Cohort Study

Role of hepatokines in non-alcoholic fatty liver disease

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