Association of several loci of SMAD7 with colorectal cancer: A meta-analysis based on case–control studies

Xiao, Qiang; Chen, Jian; Zhu, Jiang; Zeng, Shukun; Cai, Hu; Zhu, Guomin

doi:10.1097/md.0000000000032631

Cited by 2 publications

(2 citation statements)

References 53 publications

(70 reference statements)

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“…Another analysis containing a total of 34 studies looked at rs4939827 minor allele (C) [42]. It has been shown to be a protective factor against colorectal cancer, thus endorsing our results.…”

Section: Discussionsupporting

confidence: 77%

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Colorectal Cancer Risk Prediction Using the rs4939827 Polymorphism of the SMAD7 Gene in the Romanian Population

Herlo,

Dumache,

Duta

et al. 2024

Diagnostics

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Colorectal cancer (CRC) is globally recognized as a prevalent malignancy known for its significant mortality rate. Recent years have witnessed a rising incidence trend in colorectal cancer, emphasizing the necessity for early diagnosis. Our study focused on examining the impact of the SMAD7 gene variant rs4939827 on the risk of colorectal cancer occurrence. The composition of our study group included 340 individuals, comprising 170 CRC diagnosed patients and 170 healthy controls. We performed genotyping of all biological samples using the TaqMan assay on the ABI 7500 Real-Time PCR System (Applied Biosystems, Waltham, MA, USA). This investigation focused on the rs4939827 gene variant, assessing its association with CRC risk and clinicopathological characteristics. Genotyping results for the SMAD7 gene variant rs4939827 revealed a 42.6% prevalence of the C allele in CRC patients (p = 0.245) and a 22.8% prevalence of the T allele in control subjects (p = 0.109). This study concluded that there was an elevated risk of CRC in the dominant model for CC/CT+TT, with a p-value of 0.113 and an odds ratio (OR) of 2.781, within a 95% confidence interval (CI) of 0.998 to 3.456. The findings of our research indicate a correlation between variants of the SMAD7 gene and the likelihood of developing colorectal cancer in our study population. Consequently, these results could be instrumental in facilitating early diagnosis of colorectal cancer utilizing information on single-nucleotide polymorphism (SNP) and genetic susceptibility to the disease.

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Section: Discussionsupporting

confidence: 77%

“…The SNPs rs4939827, rs4464148, and rs12953717 have been extensively investigated in relation to many types of cancer. Among the several options, CRC stands out as the most prominent [42].…”

Section: Discussionmentioning

confidence: 99%

Colorectal Cancer Risk Prediction Using the rs4939827 Polymorphism of the SMAD7 Gene in the Romanian Population

Herlo,

Dumache,

Duta

et al. 2024

Diagnostics

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Genome-Wide Gene–Environment Interaction Analyses to Understand the Relationship between Red Meat and Processed Meat Intake and Colorectal Cancer Risk

Stern,

Sanchez Mendez,

Kim

et al. 2023

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: High red meat and/or processed meat consumption are established colorectal cancer (CRC) risk factors. We conducted a genome-wide gene-environment (GxE) interaction analysis to identify genetic variants that may modify these associations. Methods: A pooled sample of 29,842 CRC cases and 39,635 controls of European ancestry from 27 studies were included. Quantiles for red meat and processed meat intake were constructed from harmonized questionnaire data. Genotyping arrays were imputed to the Haplotype Reference Consortium. Two-step EDGE and joint tests of GxE interaction were utilized in our genome-wide scan. Results: Meta-analyses confirmed positive associations between increased consumption of red meat and processed meat with CRC risk (per quartile red meat OR = 1.30; 95%CI = 1.21-1.41; processed meat OR = 1.40; 95%CI = 1.20-1.63). Two significant genome-wide GxE interactions for red meat consumption were found. Joint GxE tests revealed the rs4871179 SNP in chromosome 8 (downstream of HAS2); greater than median of consumption ORs = 1.38 (95%CI = 1.29-1.46), 1.20 (95%CI = 1.12 -1.27), and 1.07 (95%CI = 0.95 – 1.19) for CC, CG and GG, respectively. The two-step EDGE method identified the rs35352860 SNP in chromosome 18 (SMAD7 intron); greater than median of consumption ORs = 1.18 (95%CI = 1.11-1.24), 1.35 (95%CI = 1.26-1.44), and 1.46 (95%CI = 1.26-1.69) for CC, CT, and TT, respectively. Conclusions: We propose two novel biomarkers that support the role of meat consumption with an increased risk of CRC. Impact: The reported GxE interactions may explain the increased risk of CRC in certain population subgroups.

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Association of several loci of SMAD7 with colorectal cancer: A meta-analysis based on case–control studies

Cited by 2 publications

References 53 publications

Colorectal Cancer Risk Prediction Using the rs4939827 Polymorphism of the SMAD7 Gene in the Romanian Population

Colorectal Cancer Risk Prediction Using the rs4939827 Polymorphism of the SMAD7 Gene in the Romanian Population

Genome-Wide Gene–Environment Interaction Analyses to Understand the Relationship between Red Meat and Processed Meat Intake and Colorectal Cancer Risk

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