Association of serum vitamin D levels and urinary tract infection in pregnant women: A case control study

Haghdoost, Simin; Pazandeh, Farzaneh; Darvish, Soodabeh; Khabazkhoob, Mehdi; Huss, Reinhard; Lak, Tahereh Behroozi

doi:10.1016/j.ejogrb.2019.10.015

Cited by 13 publications

(7 citation statements)

References 40 publications

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“…Mulheres com deficiências de vitamina D correm maior risco de infecções do trato urinário durante a gravidez. No entanto, mais estudos são essenciais para confirmar esses resultados observados (Haghdoost, 2019).…”

Section: Falta Da Vitamina D Com Resultados Na Gravidezunclassified

Deficiência e biodisponibilidade da vitamina D: Uma revisão bibliográfica

Dutra

Brito

Maia

et al. 2020

RSD

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Vitamin D is a mineral vitamin supplement, whose function is related to bone health, also responsible for other activities, regulates growth, immune system, cardiovascular, muscles, metabolism and insulin, maintaining the proper concentrations of calcium and phosphorus in the body. When combined with other micronutrients, vitamin D becomes fat-soluble, acquired through food and sunlight. The main diseases caused by lack of vitamin D were evaluated, noting that excessive consumption can cause serious problems, such as obesity, already lacking malnutrition. From the studies analyzed, it can be concluded that vitamin D bioavailability is associated with regulation and maintenance for a healthy life. This study exposes the need for maintenance of vitamins for maintenance, presenting the importance of supplementation for people over 65 years and pregnant women.

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Section: Falta Da Vitamina D Com Resultados Na Gravidezunclassified

Deficiência e biodisponibilidade da vitamina D: Uma revisão bibliográfica

Dutra

Brito

Maia

et al. 2020

RSD

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“…Mothers with preterm labor are three times more likely to have insufficiency when compared to full-term mothers 62 . Hypovitaminosis D is associated with high prevalence of infections, particularly Gardnerella vaginalis; commonly encountered in cases of PROMs and preterm labor 63 - 65 . VitD deficiency increased susceptibility to microbial infection due to macrophage dysfunction with defect in toll-like mediated action of the antibacterial peptide cathelicidin 66 .…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Status and Pregnancy Complications: Serum 1,25-di-hydroxyl-Vitamin D and its Ratio to 25-hydroxy-Vitamin D are Superior Biomarkers than 25-hydroxy-Vitamin D

Albahlol¹,

Almaeen²,

Alduraywish³

et al. 2020

Int. J. Med. Sci.

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Vitamin D (VitD) deficiency during pregnancy has been associated with adverse neonatal outcomes and increased risk of late pregnancy complications. We planned to correlate serum VitD biomarkers; 25-hydroxyvitamin D (25-OH-VitD) and 1,25-dihydroxyvitamin D (1,25-diOH-VitD) levels; and their ratio with the frequency of feto-maternal pregnancy complications. A prospective cross-sectional case-control study was conducted at Aljouf Maternity and Children Hospital, Sakaka, Saudi Arabia, during the period of September 1, 2017 to September 30, 2019. 322 pregnant women were stratified into 2 groups: controls (110 cases) and complicated group (212 cases). The later comprised severe preeclamptic toxemia associated with intrauterine growth restriction (58 cases), gestational diabetes mellitus (GDM; 82 cases), abortion (26 cases), undisturbed ectopic pregnancy (16 cases), premature rupture of membranes (PROM; 14 cases), and, inevitable preterm labour (16 cases). After clinical assessment, peripheral blood samples were collected. Serum biomarkers were measured using specific immunoassays. The direct 1,25-diOH-VitD/25-OH-VitD ratio was calculated. Serum 25-OH-VitD indicated widely spreading VitD deficiency among participants with significantly higher levels in controls vs. GDM subgroup only. 1,25-diOH-VitD levels and the ratio were markedly reduced in the six complicated subgroups vs. controls, with non-significant differences amongst the complicated subgroups. ROC analysis showed very high sensitivity and specificity, to differentiate patients from controls, only for 1,25-diOH-VitD (AUC = 0.965; 0.947 - 0.983, p <0.001) followed by the ratio but not 25-OH-VitD. In conclusions, 25-OH-VitD did not show significant changes except for GDM. 1,25-diOH-VitD levels and the ratio showed strong associations with pregnancy complications. Serum 1,25-di-OH-VitD and its ratio to 25-OH-VitD are more reliable and physiologically relevant biomarkers for VitD status in pregnancy.

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“…The relation between the status serum level of vitamin D and the risk of UTI has been studied extensively, and the results showed a significant association between increased risk of UTI and vitamin D insufficiency, as an independent risk factor, especially in children [72][73][74]. Women with vitamin D deficiencies show a higher risk level of UTI during pregnancy [75]. Vitamin D deficiency is common and the proven risk factor for UTIs especially in girls and supplementation with vitamin D could prevent first-time UTI [76].…”

Section: Vitaminsmentioning

confidence: 99%

Deep insights into urinary tract infections and effective natural remedies

et al. 2021

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Background Urinary tract infection (UTI) is a common occurrence in females, during pregnancy, and in peri- and postmenopausal women. UTIs are associated with significant morbidity and mortality, and they affect the quality of life of the affected patients. Antibiotic therapy is an effective approach and reduces the duration of symptoms. Development of resistance, adverse effects of antibiotics, and other associated problems lead to establishing the research framework to find out the alternative approaches in controlling UTIs. Natural approaches have been extensively used for the management of various diseases to improve symptoms and also improve general health. Main body Different databases were employed to identify studies reporting on natural options including herbal medicines, vitamins, trace elementals, sugars, and probiotics without time limitations. Conclusion Herbal medicines can be effective at the first sign of the infection and also for short-term prophylaxis. Using vitamins, trace elementals, and/or sugars is an effective approach in preventing UTIs, and a combination of them with other antibacterial agents shows positive results. Probiotics have great potential for the threat of antibiotic over-usage and the prevalence of antibiotic-resistant microorganisms. This study may be of use in developing the efficient formulation of treatment of UTI.

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Association of serum vitamin D levels and urinary tract infection in pregnant women: A case control study

Cited by 13 publications

References 40 publications

Deficiência e biodisponibilidade da vitamina D: Uma revisão bibliográfica

Deficiência e biodisponibilidade da vitamina D: Uma revisão bibliográfica

Vitamin D Status and Pregnancy Complications: Serum 1,25-di-hydroxyl-Vitamin D and its Ratio to 25-hydroxy-Vitamin D are Superior Biomarkers than 25-hydroxy-Vitamin D

Deep insights into urinary tract infections and effective natural remedies

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