Association of serum vitamin D levels and transient tachypnea of newborn: a case control study

Singh, Gurmeet; Sood, Reena; Narang, Gursharan Singh; Brar, Harnoorjit Kaur; Bagga, Amanjeet Kaur

doi:10.18203/2349-3291.ijcp20171526

Cited by 3 publications

(4 citation statements)

References 27 publications

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“…In neonates, forms of the vitamin taken orally reach equivalence in their capacity to increase circulation vitamin D levels at a postnatal age of about 89 days [38]. Preterm and term infants born with vitamin D deficiency are more likely to experience respiratory distress syndrome, neonatal transient tachypnea (TTN), acute lower respiratory tract infection, and early and late neonatal sepsis (LOS) than infants with optimal vitamin D levels, according to published research on the effects of vitamin D on the respiratory and immune systems [39][40][41][42][43]. As mentioned in the literature, our study also revealed that infants with low cord vitamin D levels had higher rates of respiratory distress from neonatal transient tachypnea and EOS, as well as longer hospital stays both in terms of frequency and duration.…”

Section: Discussionmentioning

confidence: 99%

A Prospective Cross-Sectional Study on the Vitamin D Status of Neonates and the Impact of Neonates’ Standard Vitamin D Supplementation on Neonatal Morbidities

Yangin Ergon,

Dorum,

Balki

et al. 2024

Children

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(1) Background: This study aimed to determine whether standard-dose vitamin D supplementation could provide adequate levels in exclusively breastfed infants born with different cord 25(OH)D levels and to evaluate related neonatal morbidities. (2) Methods: A prospective cross-sectional study was designed in term infants. Three groups were formed based on cord 25(OH)D levels; Group1 Deficiency:25(OH)D < 12 ng/mL, Group2 Insufficiency:25(OH)D = 12–19 ng/mL, and Group3 Optimum:25(OH)D = 20–100 ng/mL. Cord and 1st month 25(OH)D levels, after receiving standard-dose vitamin D prophylaxis, neonatal outcomes and anthropometric measurements were compared. (3) Results: The study involved 86 infants. Group1 Deficiency had also significantly lower 25(OH)D levels at 1st month compared to the others (p < 0.001). There was a significant positive correlation between cord and 1st month 25(OH)D levels (r = 0.78, p < 0.001). Despite the fact that the mother’s age and clothing style were similar, Group1 Deficiency mothers had higher parity numbers and used less vitamin D during pregnancy (p = 0.03, p = 0.04). Neonatal outcomes analysis revealed that newborns in Group1 Deficiency experienced more respiratory distress, transient tachypnea, and early-onset sepsis, as well as more and longer hospital stays in the first-month of life (p < 0.05). (4) Conclusions: Infants with low cord 25(OH)D levels had also lower 25(OH)D values in the 1st month of life and experienced higher rates of neonatal morbidities. Given its numerous biological activities and impact on neonatal morbidities, determining an individualized dose of vitamin D supplementation may be more accurate than using the standard approach.

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Section: Discussionmentioning

confidence: 99%

A Prospective Cross-Sectional Study on the Vitamin D Status of Neonates and the Impact of Neonates’ Standard Vitamin D Supplementation on Neonatal Morbidities

Yangin Ergon,

Dorum,

Balki

et al. 2024

Children

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“…Tedavi süresi uzamış YGT de sürfaktan yetersizliği veya disfonksiyonunun göz önünde bulundurulmasını gerektiğini savunan yazarlar da vardır (16,17) . Vitamin D eksikliği, akciğer yapısında değişiklikler ile birlikte sürfaktan üretiminde bozulmaya da neden olabilir (18) . Machado ve ark.…”

Section: Discussionunclassified

“…Yenidoğanlarda tüm solunum sıkıntısı nedenlerinin %40'ından fazlasını YGT oluştururken YGT dışı en sık görülen solunum sıkıntısı nedenlerini pnömoni, mekonyum aspirasyon sendromu, pnömotoraks, pulmoner arteryel hipertansiyon, hipoksik iskemik ensefolopati oluşturmaktadır (18) . Çalışmamızda, solunum Karatekin ve ark.…”

Section: Discussionunclassified

“…Vitamin D'nin, kathelidin gibi antimikrobiyal peptitlerin üretiminde doğrudan bir rolü vardır, böylece enfeksiyonları önlemedeki rolü açıklanabilir. Bronşiyal epitel 25 (OH) D3'ü lokal aktif 1,25 (OH) 2 D3'e dönüştürebilir, bu da inflamatuvar sitokinlerin ve kemokinlerin üretimini azaltır ve antimikrobiyal peptitlerin sentezini arttırır (18) . Dinlen ve ark.…”

Section: Discussionunclassified

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Association of Vitamin D Deficiency with Postnatal Respiratory Distress in Newborns

Say¹,

Öncel²,

Uraş³

2019

BUCH

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GİRİŞYenidoğanların yaklaşık %1'inde solunum sıkıntısı görülmekte ve bunların da %4,0 ile %5,7 kadarını yenidoğanın geçici takipnesi (YGT) kalanını da mekon-yum aspirasyon sendromu, pnömoni, sepsis, pnömotoraks gibi diğer nedenler oluşturmaktadır. Term bebeklerde solunum sıkıntısı risk faktörleri arasında; sezaryen doğum, zamanından önce doğum, koriyoamnionit, erkek cinsiyet, sepsis, düşük apgar, diyabe-ÖZ Amaç: Yenidoğanın geçici takipnesi (YGT), yaşamın ilk üç gününde düzelen, erken neonatal dönemde solunum sıkıntısının en yaygın nedenlerinden biridir. Çalışmanın amacı, serum 25 hidroksi vitamin D (25(OH)D) seviyesinin YGT ve YGT dışı solununum sıkıntısı nedenleri üzerine etkisini araştırmaktır. Yöntem: Bu çalışma Zekai Tahir Burak Kadın Sağlığı ve Hastalıkları Hastanesi, yenidoğan yoğun bakım ünitesi'nde prospektif, vaka-kontrol olarak planlandı. Çalışma grubu 36 gestasyonel haftadan büyük ve doğumdan hemen sonra solunum sıkıntısı gelişen 58 hastayı kapsamaktadır. Hastaların doğumdan hemen sonra serum 25(OH)D vitamini düzeyleri ölçüldü ve klinik, laboratuvar, radyolojik bulguları ile değerlendirilerek tanıları konuldu. Bulgular: Çalışma popülâsyonunda toplam 58 (34 erkek, 24 kız) yenidoğan vardı. Solunum sıkıntısı olan 36 hastadan 24 (%66)'ünde YGT, 12 (%34)'inde ise YGT dışı (neonatal pnömoni, pnömotoraks ve mekonyum aspirasyon sendromu) tespit edilmiştir. 31 (%53.4) yenidoğanın serum 25(OH)D seviyeleri ≤5 ng/mL (grup 1), 17 olgunun (%29.3) 25(OH)D seviyeleri 5-15 ng/mL arasında (grup 2), 10 olgunun (% 17.2) 25(OH)D seviyeleri > 15 ng/ mL idi (grup 3). Sonuç: Sonuç olarak, bebeklerde serum D vitamini yetersizliğinin YGT ve YGT dışı solunum sıkıntısı nedenleri için risk oluşturmadığı görüldü. 25(OH)D vitamini düzeyinin doğum sonrası dönemde solunum sıkıntısı ile ilişkisi olup olmadığını kanıtlamak için iyi tasarlanmış yeni çalışmalara ihtiyaç vardır. Anahtar kelimeler: Solunum sıkıntısı, yenidoğan, 25 (OH) D vitamini eksikliği ABSTRACT Objective: Transient tachypnea of newborn (TTN) is one of the most prevalent cause of respiratory distress which resolves within the first three days of life. The aim of this study was to investigate the effects of serum 25 hydroxy vitamin D (25 (OH) D) levels on the causes of TTN and non-TTN.Methods: This case-control study was conducted in neonatal intensive care unit of the Zekai Tahir Burak Maternity Teaching Hospital in Turkey. We enrolled 58 neonates with gestational age of ≥36 weeks who developed respiratory distress soon after birth. Serum 25 (OH) D levels were measured immediately after birth of the neonate and clinical, laboratory and radiological findings were evaluated and diagnosed. Results: The study population included a total of 58 (34 boys, 24 girls) newborns . Among the 36 patients with respiratory distress, 24 (66%) of them had TTN, 12 (34%) of them had non-TTN respiratory distress (neonatal pneumonia, pneumothorax and meconium aspiration syndrome). Of these infants, 31 (53.4%) had cord blood 25 (OH) D levels ≤5 ng/mL (Group 1), 17 (29.3%) had 25 (OH) D levels...

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Vitamin D Deficiency, Prevalence and Treatment in Neonatal Period

Fedakar

2019

EMIDDT

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Objective: Maternal vitamin D deficiency is an important risk factor that causes infantile rickets in the neonatal and infantile period. The aim of this study was to review the prevalence, clinical characteristics, and treatment of vitamin D deficiency and the follow-ups with infants and their mothers by the neonatal intensive care unit of Afiyet Hospital in Turkey. Methods: Calcium (Ca), phosphorus (P) and 25 (OH) vitamin D were studied and prospectively recorded in infants and their mothers detected to have hypocalcemia during routine biochemistry tests performed on the third postnatal day of the patients follow up and treated with different diagnoses. Results: A total of 2,460 infants were admitted into the neonatal intensive care unit between August 2014 and January 2018. Of the infants included in the study, 324 (66.1%) were male and 166 (33.8%) were female, and 366 (74.6%) of them had been delivered by cesarean section (C/S), 124 (25.3%) of them had been delivered by Normal Spontaneous Delivery (NSD). Hypocalcemia was detected in 490 (19.9%) of the infants. In a total of 190 (38.7%) infants and 86 mothers (17.5%), the levels of 25 (OH) vitamin D were found to be below the laboratory detection limit of <3 ng/ml. When vitamin D deficiency + insufficiency is assessed by season, 151 of them were found to be in summer (30.99%), 118 in spring (24.18%), 117 in the winter season(23.87%), and 93 in autumn(18.97%), respectively. There was a statistically significant positive correlation of 78.7% between the vitamins D values of the mothers and the infants (p: 0.000, p<0.05). Conclusion: This study conducted that a positive correlation of between the vitamin D values of the mothers and the infants. In order to prevent maternal vitamin D deficiency, the appropriate dose of prophylaxis providing optimal levels of vitamin D and should be given by according to the levels of 25 (OH) D vitamin during pregnancy.

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Association of serum vitamin D levels and transient tachypnea of newborn: a case control study

Cited by 3 publications

References 27 publications

A Prospective Cross-Sectional Study on the Vitamin D Status of Neonates and the Impact of Neonates’ Standard Vitamin D Supplementation on Neonatal Morbidities

A Prospective Cross-Sectional Study on the Vitamin D Status of Neonates and the Impact of Neonates’ Standard Vitamin D Supplementation on Neonatal Morbidities

Association of Vitamin D Deficiency with Postnatal Respiratory Distress in Newborns

Vitamin D Deficiency, Prevalence and Treatment in Neonatal Period

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