Association of serum vitamin D level with glycemic control in patients with type 2 diabetes mellitus

Abstract

Background and objective: Vitamin D deficiency appears to be related to the development of diabetes mellitus type 2 and metabolic syndrome. This study aimed to assess the association between the level of 25-hydroxy vitamin D{25(OH)D3 and the glycemic control in patients with type 2 diabetes. Methods: This case-control study involved 240 participants divided into two groups, 119 patients with type 2 diabetic mellitus and 120 healthy individuals as a control group. The study was conducted in Layla Qassim Diabetic Center in Erbil from March 2018 to March 2019. The data were collected from all the cases, including history and physical examination, using a specially designed questionnaire. From all cases, blood was taken, and samples were sent to the laboratory for serum vitamin D3 level estimation. Results: From the total of 240 participants, the mean age of cases was 54.04 ± 10.56 years and of controls was 53.12 ± 9.84 years. The mean serum vitamin D3 level of the cases was 9.21 ± 5.69ng/ml, and it was non-significantly (P = 0.3) higher than the control (8.61±4.57)ng/ml. Both groups were within the vitamin D deficient range. Vitamin D level was non-significantly deficient in 84 (70.6%) of diabetic patients compared to 89(73.6%) of control. There was a non-significant difference in vitamin D level in poorly controlled diabetic patients compared to well-controlled diabetic patients (P = 0.584). Conclusion: No significant association was detected between vitamin D level and glycemic control. Keywords: Type 2 diabetes mellitus; Vitamin D3 level; Glycemic control.

Serum vitamin D in sanctuary chimpanzees (Pan troglodytes) in range countries: A pilot study

“…There is an increasing recognition that vitamin D plays a crucial role in female reproduction (Xu et al., 2021) as well as in spermatogenesis (Zanatta et al., 2017). Low serum concentrations of 25‐OH‐D in humans have been associated with an increased risk of mortality and a variety of disorders including musculoskeletal diseases, diabetes mellitus, cardiovascular diseases, autoimmune diseases, cancer, gestational diabetes, and fertility issues (Dusso et al., 2005; Haidari et al., 2016; Holick, 2017; Pilz et al., 2018; Poel et al., 2012; Zhang & Naughton, 2010). Metabolic bone disease or rickets due to vitamin D deficiency has been documented in chimpanzees (Pan troglodytes) , and a wide range of non‐human primates under human care (Junge et al., 2000; Knapka, 2003; Power et al., 1995).…”