Association of Serum Uric Acid and Coronary Artery Disease in Premenopausal Women

Abstract

ObjectiveTo date, no study in the published literature has investigated the role of various serum uric acid (SUA) concentrations in the development of angiographically-proven coronary artery disease (CAD) in premenopausal women. Therefore, the aim of this study was to investigate the role SUA levels may play in the prevalence, severity, and prognosis of CAD in premenopausal women.MethodsThis cross-sectional retrospective study included 607 premenopausal women who had undergone coronary angiography. The CAD diagnosis was based upon stenosis affecting ≥50% of the luminal diameter. Association of the SUA levels with CAD prevalence, severity, and clinical outcomes were assessed by statistical analysis.ResultsIn total, 369 (60.8%) of the patients were diagnosed with CAD. The CAD patients had significantly higher SUA levels than those without CAD (5.3±1.9 vs. 4.8±1.7 mg/dL, P = 0.001). The SUA levels were found to be significantly associated with CAD prevalence (P = 0.013). Patients with higher levels of SUA also showed increased rates of multivessel disease and composite end-points, such as major adverse cardiac events. Furthermore, multivariate analysis identified abnormally high levels of uric acid (hyperuricemia) as an independent risk factor for CAD (OR 1.51 (1.11–2.53), P<0.05).ConclusionsThe SUA levels are significantly associated with the prevalence of CAD. The SUA levels may be a predictor for incidence of major cardiovascular events in premenopausal women.

Role of Serum Uric Acid in the Assessment of Stroke

“…[23] The increased serum uric acid level was also found to be associated with the severity of CAD in both men and women. In the present study significant relationship was observed between uric acid and CAD similar results were reported from a study with 1012 patients who underwent coronary angiography in Turkish population, [24] cross-sectional retrospective study included 607 premenopausal women who had undergone coronary angiography [25] and also in hospital-based case-control study conducted in patients attending the affiliated hospital of Qingdao university, China. [26] Hyperuricaemia predisposes to the progress of hypertension and oxidative stress may increase and generates free radicals, which eventually acts as source of future cardiovascular disease risk.…”

Research update for articles published inEJCIin 2013

“…Uric acid and prognosis in angiography-proven coronary artery disease [15] (Gjin Ndrepepa) In our study that included 13 273 patients with angiographic confirmation of coronary artery disease (CAD) treated with percutaneous coronary intervention, we concluded that uric acid (UA) predicted an increased risk of cardiac and all-cause mortality across all subsets of the patients and that the association between UA and cardiac or all-cause mortality had a 'J-shaped' pattern with lowest risk of death in patients with UA levels between 5Á17 and < 6Á76 mg/dL. Since its publication, evidence has gathered that elevated UA level is associated CAD and/or increased incidence of cardiovascular adverse events [16][17][18][19][20]. One recent study in which UA was measured in 3315 patients showed that UA was associated with CAD and it was causally related to adverse cardiovascular events, especially sudden cardiac death [16].…”

Women and Heart Disease: Understanding Risk Factors for Coronary Artery Disease

“…59 In a cross-sectional retrospective study of 607 premenopausal women who had undergone coronary angiography, serum uric acid levels were associated with the presence of CAD. 60 This finding was confirmed in patients with transient ischemic attacks or stroke; an elevated uric acid level independently predicted long-term CAD in women but not men. 61 It is as yet unclear whether lowering uric acid levels reduces CVD risk.…”