Association of Serum Total Bilirubin and Uric Acid with Low Glomerular Filtration Rate Diabetic Kidney Disease in Type 2 Diabetic Patients

Tafese, Rihobot; Genet, Solomon; Addisu, Sisay

doi:10.2147/dmso.s391777

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…57 Other clinical explorations have found that bilirubin is associated with the renal function, macrovascular or microvascular complications such as urinary albumin excretion. [58][59][60] Therefore, these findings could support that mildly increased serum bilirubin, especially SBiL could be have a protective consequence on DFU, thus, maintenance of the levels of SBiL or the antioxidant ability maybe a critical target for DFU.…”

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confidence: 74%

The Metabolic Characteristics of Patients at the Risk for Diabetic Foot Ulcer: A Comparative Study of Diabetic Patients with and without Diabetic Foot

Li,

Wen,

Dong

et al. 2023

DMSO

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Backgrounds and Objective Diabetic foot is a relatively severe complication in patients with type 2 diabetes (T2D), with peripheral neuropathy and angiopathy frequently serving as risk factors. However, it is unknown how the other major systemic metabolic factors impacted the profile of these patients, besides glucose management. Thus, we investigated the distinct characteristics of patients with diabetic foot ulcers and their relationships with angiopathy. Materials and Methods We obtained the laboratory data of 334 diabetic patients at Shanghai Pudong Hospital from 2020 to 2023. The comparisons were performed between the groups with or without diabetic foot, including glucose metabolism, lipids profile, liver and kidney function, thyroid function, and serum iron. The association between metabolic factors and lower extremity computed tomography angiography (CTA) was analyzed. Results We found significant disparities between groups in relation to age, serum protein content, liver transferase, serum creatinine, estimated glomerular filtration rate (eGFR), serum uric acid (UA), small dense low-density lipoprotein (sdLDL), lipoprotein A (LP(a)), apolipoprotein A1 (APOA1), thyroid function, serum iron, and hemoglobin (Hb) (p<0.05). The Spearman correlational analyses showed that the severity of CTA, categorized by the unilateral or bilateral plaque or occlusion, was positively significantly correlated with UA (r=0.499), triglyceride (TG) (r=0.751), whereas inversely correlated with serum albumin (r=−0.510), alanine aminotransferase (r=−0.523), direct bilirubin (DBil) (r=−0.494), total bilirubin (TBil) (r=−0.550), Hb (r=−0.646). Conclusion This cross-section investigation showed that compared to T2D only, the patients with diabetic foot ulcer (DFU) might display similar glucose metabolic control context but adverse metabolic profiles, and this profile is associated with macrovascular angiopathy characteristics and their severity.

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confidence: 74%

The Metabolic Characteristics of Patients at the Risk for Diabetic Foot Ulcer: A Comparative Study of Diabetic Patients with and without Diabetic Foot

Li,

Wen,

Dong

et al. 2023

DMSO

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“…Tafese R et al. ( 14 ) showed that the serum total bilirubin level was significantly lower in DN patients compared with non-DN patients and was significantly associated with an increased risk of DN patients. A 10-year observational cohort study in Japanese patients with diabetes was to evaluate the association of baseline serum TBIL levels with progression of DN and found that serum TBIL levels were negatively associated with PRD in diabetic nephropathy and its cut-off point was 0.5 mg/dL ( 8 ).…”

Section: Discussionmentioning

confidence: 99%

Temporal alteration of serum bilirubin levels and its renoprotective effects in diabetic kidney disease: exploring the hormonal mechanisms

Cao,

Wei,

et al. 2024

Front. Endocrinol.

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ObjectiveThis current study represents a novel endeavor to scrutinize the correlation between the temporal alteration in serum total bilirubin (TBIL) concentrations and the rate of estimated glomerular filtration rate (eGFR). Additionally, this study aims to probe the plausible molecular mechanism underpinning the renoprotective effects of bilirubin concerning its hormonal characteristics.Materials and methodsIn this study, a cohort of 103 patients diagnosed with DKD and receiving medical care at Dongzhimen Hospital were recruited and monitored over a period of 2-7 years. The progression of DKD was ascertained using a threshold of eGFR decline > -5.48%/year. To assess the relationship between the annual change in serum TBIL levels (%/year) and the slope of eGFR, multivariate binary logistic regression analysis was employed. Furthermore, the ROC curve analysis was employed to determine the cut-off value for TBIL levels (%/year).ResultsThe use of multivariate binary logistic regression models revealed that serum TBIL levels (%/year) exhibited a significant correlation with the slope of eGFR. Moreover, the ROC curve analysis indicated a cut-off value of -6.729%/year for TBIL levels (%/year) with a sensitivity of 0.75 and specificity of 0.603, in diagnosing eGFR decline >-5.48%/year.ConclusionsThe findings of this study suggest that the sustained elevation of serum bilirubin concentration within the physiological range can effectively retard the progression of Diabetic Kidney Disease (DKD). Furthermore, the hormonal attributes of bilirubin may underlie its renoprotective effects.

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“…Although bilirubin may have an unknown role in activating other pathways, PPAR α has been shown to be a direct binding protein for bilirubin as a ligand agonist. Recent studies indicated that bilirubin only selectively bound PPAR α and did not interact with PPAR γ or PPAR δ [24]. It is therefore speculated that the speci c mechanism by which higher levels of bilirubin delay DN progression is related to the hormonal properties of bilirubin.…”

Section: Discussionmentioning

confidence: 99%

Temporal Alteration of Serum Bilirubin Levels and its Renoprotective Effects in Diabetic Nephropathy: Exploring the Hormonal Mechanisms

Cao

Wei

et al. 2023

Preprint

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Objective This current study represents a novel endeavor to scrutinize the correlation between the temporal alteration in serum total bilirubin (TBIL) concentrations and the rate of estimated glomerular filtration rate (eGFR). Additionally, this study aims to probe the plausible molecular mechanism underpinning the renoprotective effects of bilirubin concerning its hormonal characteristics. Materials and Methods In this study, a cohort of 103 patients diagnosed with DN and receiving medical care at Dongzhimen Hospital were recruited and monitored over a period of 2–7 years. The progression of DN was ascertained using a threshold of eGFR decline > -5.48%/year. To assess the relationship between the annual change in serum TBIL levels (%/year) and the slope of eGFR, multivariate binary logistic regression analysis was employed. Furthermore, the ROC curve analysis was employed to determine the cut-off value for TBIL levels (%/year). Results The use of multivariate binary logistic regression models revealed that serum TBIL levels (%/year) exhibited a significant correlation with the slope of eGFR. Moreover, the ROC curve analysis indicated a cut-off value of -6.729%/year for TBIL levels (%/year) with a sensitivity of 0.75 and specificity of 0.603, in diagnosing eGFR decline >-5.48%/year. Conclusions The findings of this study suggest that the sustained elevation of serum bilirubin concentration within the physiological range can effectively retard the progression of diabetic nephropathy (DN). Furthermore, the hormonal attributes of bilirubin may underlie its renoprotective effects.

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Association of Serum Total Bilirubin and Uric Acid with Low Glomerular Filtration Rate Diabetic Kidney Disease in Type 2 Diabetic Patients

Cited by 5 publications

References 20 publications

The Metabolic Characteristics of Patients at the Risk for Diabetic Foot Ulcer: A Comparative Study of Diabetic Patients with and without Diabetic Foot

The Metabolic Characteristics of Patients at the Risk for Diabetic Foot Ulcer: A Comparative Study of Diabetic Patients with and without Diabetic Foot

Temporal alteration of serum bilirubin levels and its renoprotective effects in diabetic kidney disease: exploring the hormonal mechanisms

Temporal Alteration of Serum Bilirubin Levels and its Renoprotective Effects in Diabetic Nephropathy: Exploring the Hormonal Mechanisms

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