Association of serum stromal cell-derived factor 1 levels with EZSCAN score and its derived indicators in patients with type 2 diabetes

Liu, Wangshu; Hua, Ling-yan; Zhu, Su-Xiang; Xu, Feng; Wang, Xueqin; Lu, Chunfeng; Su, Jianbin; Qi, Feng

doi:10.1530/ec-21-0629

Cited by 3 publications

(3 citation statements)

References 37 publications

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“…The EPC mobilization is controlled by chemokines such as SDF-1, VEGF, granulocyte-colony stimulating factor (G-CSF), and CXCR4. 47,48 Still, the SDF-1/ CXCR4 axis is activated in diabetes, 49,50 indicating that other mechanisms are at play. Insulin resistance is a possible culprit, since the development of insulin resistance and diabetes has been shown to lead to weaker EPCs.…”

Section: Discussionmentioning

confidence: 99%

CCN1 inhibition affects the function of endothelial progenitor cells under high-glucose condition

Dong,

Zhou,

Zhang

2023

Adv Clin Exp Med

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Background. The impact of cysteine-rich angiogenic inducer 61 (Cyr61, also called CCN1) on endothelial progenitor cells (EPCs) from diabetic-rat-derived whole peripheral and bone marrow remains poorly understood. Therefore, the expression levels of CCN1, CCN1-induced C-X-C chemokine receptor type 4 (CXCR4), and stromal-cell-derived factor-1 (SDF-1) were explored under high glucose (HG) conditions.Objectives. The aim of the study was to explore the effects of high CCN1 levels on EPC activity in diabetic rats through mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway modulation. Materials and methods.Primary EPCs were isolated from bone marrow and whole peripheral blood of streptozocin (STZ)-induced diabetic Sprague-Dawley rats and controls. Cell migration, tube formation ability and viability were determined using transwell, Cell Counting Kit-8 (CCK-8), and Matrigel®-based capillary-like tube formation assays. Protein and gene expression levels were measured by western blot and real-time quantitative polymerase chain reaction (RT-qPCR).Results. The study findings showed that EPC migration, viability and tube formation ability were significantly lower under HG conditions. High CCN1 expression levels restored EPC function by inducing SDF-1 and CXCR4 in EPCs under HG conditions. Furthermore, HG suppressed MEK/ERK phosphorylation, while an ERK1/2 agonist rescued EPC CCN1-SDF-1/CXCR4 expression under HG conditions through the activation of the MEK/ERK pathway.Conclusions. This study demonstrates that high CCN1 expression levels restored EPC functions, partly by modulating MEK/ERK signaling. These findings provide a basis for developing novel therapeutic methods for diabetic vascular neogenesis and vascular injury repair.

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Section: Discussionmentioning

confidence: 99%

CCN1 inhibition affects the function of endothelial progenitor cells under high-glucose condition

Dong,

Zhou,

Zhang

2023

Adv Clin Exp Med

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“…Peripheral blood inflammatory cell count and its associated markers are now often employed in clinical practice as a reflection of inflammation. These markers are thought to be readily available biomarkers linked to an elevated risk of CAD, stroke, and mortality overall [4] .…”

Section: Introductionmentioning

confidence: 99%

“…The systemic inflammatory response index (SIRI) is a new indication that has just surfaced. Based on the absolute counts of three distinct inflammatory cell types-neutrophils, monocytes, and lymphocytes-SIRI is a composite indicator [4] . High SIRI levels are associated with a higher risk of MI and mortality in general [5] .…”

Section: Introductionmentioning

confidence: 99%

Value of Systemic Inflammatory Response Index as a Novel Prognostic Biomarker and Severity Assessment in Patients with Acute Coronary Syndrome

2024

The Egyptian Journal of Hospital Medicine

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Background: Over 15 million people died globally from acute coronary syndrome (ACS) in 2019, with individuals under 70 years old accounting for 40% of these untimely fatalities. Objective: To investigate the prognostic value of systemic inflammatory response index (SIRI) in ACS patients as an independent risk factor for adverse events, and assessment severity of coronary artery disease. Patients and Methods: A prospective cohort study was conducted on 130 patients with ACS patients (ST-elevation myocardial infarction (STEMI), non-ST elevation myocardial infarction (NSTEMI), Unstable Angina). In addition to evaluation of SIRI, comprehensive clinical evaluations, lab tests, and subsequent appointments were conducted for thorough analysis. Results: The mean SIRI was 1.042 ± 0.4, the mean Syntax Score was 18.77 ± 3.54. There was nonsignificant difference in between the two groups as regard to sex, age, SBP, DBP, and HR. There was a significant difference in between survived and died cases as regard to family history, Killip class and number of vessels affected, and also, in between SYNTAX score more than 22 and below 22 as regard to troponin, creat, cholesterol, neutrophils, and monocytes. The Sensitivity of SIRI and SYNTAX score as a predictor of outcome of ACS was 90% and 84.85%, the specificity was 94% and 82.69% and the cut-off point was >0.744 and >22 respectively. There was a significant positive correlation in between SIRI and Age, Killip class, cholesterol, lymphocytes, number of vessels affected, Syntax score, number of dead cases, number of non-fatal MI, and number of strokes. According to the SIRI, univariate analysis showed that the most prevalent unfavourable outcome was death, non-fatal myocardial infarction, and stroke. Conclusions: SIRI could be used as an inflammatory biomarker for the prognosis of patients with ACS.

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Association of SDF-1-3′ Gene A Variant with Diabetic Retinopathy in the Hungarian Population

Ecsedy,

Kovacs,

Szigeti

et al. 2024

IJMS

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We investigated the association between the SDF-1-3′ (c801G > A) variant and the development of diabetic macular edema (DME) or proliferative diabetic retinopathy (PDR) in a Hungarian cohort. SDF-1-3′ (c801G > A) was genotyped in 103 patients with diabetic retinopathy and 31 age- and sex-matched non-diabetic controls. Central retinal and choroidal thickness was measured by swept-source optical coherence tomography. The distribution of heterozygous and homozygous SDF-1-3′ (c801G > A) genotypes was similar in diabetic and control subjects. The SDF-3′(c801AA) genotype was associated with DME (n = 94 eyes, allele distribution p = 0.006, genotype distribution p = 0.01 OR: 2.48, 95% CL: 1.21–5.08) in both univariable and multivariable modelling, independent of duration and type of diabetes, HbA1C, hypertension and microalbuminuria (p = 0.03). DME occurred earlier in patients carrying the SDF-1 (c801A) allele (Kaplan–Meier analysis, log-rank test p = 0.02). A marginally significant association was found between the presence of the SDF-1 (c801A) allele and the development of PDR (n = 89 eyes, p = 0.06). The SDF-1-3′ (c801A) allele also showed a correlation with central retinal (p = 0.006) and choroidal (p = 0.08) thickness. SDF-1-3′ (c801G > A) is involved in the development of macular complications in DM independent of critical clinical factors, suggesting that SDF-1 may be a future therapeutic target for high-risk patients, especially those carrying the SDF-1 (c801A) allele.

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Association of serum stromal cell-derived factor 1 levels with EZSCAN score and its derived indicators in patients with type 2 diabetes

Cited by 3 publications

References 37 publications

CCN1 inhibition affects the function of endothelial progenitor cells under high-glucose condition

CCN1 inhibition affects the function of endothelial progenitor cells under high-glucose condition

Value of Systemic Inflammatory Response Index as a Novel Prognostic Biomarker and Severity Assessment in Patients with Acute Coronary Syndrome

Association of SDF-1-3′ Gene A Variant with Diabetic Retinopathy in the Hungarian Population

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