Association of serum Spp1 levels with disease progression in ALS and SBMA
Woohee Ju,
Jae‐Jun Ban,
Hye‐ryeong Im
et al.
Abstract:ObjectiveIn comparison with amyotrophic lateral sclerosis (ALS), the contribution of neuroinflammation in spinobulbar muscular atrophy (SBMA) has been less explored. We investigated the role of neuroinflammation in the pathogenesis of ALS and SBMA by analyzing systemic inflammatory markers and osteopontin (Spp1).MethodsThis study involved 105 ALS, 77 SBMA, and 55 healthy controls. We measured their systemic inflammatory markers, serum Spp1, and cytokine levels (interferon‐γ, interleukin [IL]‐1β, IL‐6, IL‐8, IL… Show more
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