Association of serum prostate-specific antigen (PSA) level and circulating tumor cell-based PSA mRNA in prostate cancer

Cho, Hyungseok; Oh, Cheol Kyu; Cha, Jiwon; Chung, Jae Il; Byun, Seok‐Soo; Hong, Sung Kyu; Chung, Jin Hoon; Han, Ki-Ho

doi:10.1016/j.prnil.2022.01.002

Cited by 12 publications

(8 citation statements)

References 34 publications

(59 reference statements)

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“…Cells synthesizing PSA in the blood may point to the existence of micrometastases or an indicator of dissemination in the body of tumor cells [5] .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Management of a localized prostatic adenocarcinoma despite the very high rate of PSA and the large tumor mass: Does PSA level indicate the stage of prostate cancer?

el Farhaoui,

Jdaini,

Elabbassi

et al. 2023

Radiology Case Reports

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“…Cells synthesizing PSA in the blood may point to the existence of micrometastases or an indicator of dissemination in the body of tumor cells [5] .…”

Section: Discussionmentioning

confidence: 99%

“…Cho et al. [5] demonstrated that PSA mRNA correlated with serum PSA levels in metastatic prostate cancer (PCa) but not in localized PCa.…”

Section: Discussionmentioning

confidence: 99%

Management of a localized prostatic adenocarcinoma despite the very high rate of PSA and the large tumor mass: Does PSA level indicate the stage of prostate cancer?

el Farhaoui,

Jdaini,

Elabbassi

et al. 2023

Radiology Case Reports

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“…PSA was also usually performed as a marker in the screening and assessment of treatment effect in prostate malignant tumor [ 6 ]. Previous research studies found that increased PSA levels were closely associated with the clinical phase of prostate malignant tumor and the higher PSA concentration indicated the worse damage of surrounding tissues and malignant degree [ 17 ]. This study revealed that MRI combined with CEUS showed a high specificity and sensitivity in patients with different increased PSA concentrations.…”

Section: Discussionmentioning

confidence: 99%

Study on the Diagnostic Value of Contrast-Enhanced Ultrasound and Magnetic Resonance Imaging in Prostate Cancer

Pang¹,

Zhang²,

Chen³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. The aim is to study the different roles of single and joint application of magnetic resonance imaging (MRI) and contrast-enhanced ultrasound (CEUS) in prostate malignant tumors. Methods. 72 patients with prostate masses who underwent CEUS and MRI examination in our hospital from October 2021 and March 2022 were enrolled in this research. The differentially diagnostic roles of CEUS, MRI, and CEUS combined MRI for prostate cancer was assessed on basis of pathological findings as the reference standard. The specificity and sensitivity of the joint application for prostate malignant tumors with various prostate-specific antigen (PSA) levels were also evaluated. Results. The sensitivity of CEUS, MRI, and the joint application for prostate cancer were 72.1%, 74.4%, and 90.7%, respectively. Compared with single application, the sensitivity of CEUS combined with MRI was significantly higher. The specificity of MRI, CEUS, and the combination of the two for prostate cancer were 82.8%, 79.3%, and 89.7%, respectively, and the statistical differences for specificity were not found. The area under ROC curve (AUC) of CEUS combined with MRI in prostate malignant tumor diagnosis was obviously more than that of CEUS and MRI ( P < 0.05 ). CEUS combined with MRI has relative high sensitivity in these patients with different levels of PSA. Conclusions. Contrast-enhanced ultrasound combined with MRI can significantly improve the sensitivity and specificity of prostate cancer diagnosis so that patients can be better diagnosed in advance.

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“…Furthermore, genetic susceptibility, androgens, and environmental factors such as diet are the most important known risk factors for PCa [ 164 , 165 ]. Prostate-specific antigen (PSA) is the most important marker for screening, diagnosis, staging, and monitoring response to treatment of PCa [ 166 , 167 ]. Treatment strategies are based on cancer stage and tumor characteristics, including radiation therapy, hormonal therapy, chemotherapy, surgery, and cryotherapy [ 168 ].…”

Section: Autophagy and Aging-related Conditionsmentioning

confidence: 99%

Autophagy, a critical element in the aging male reproductive disorders and prostate cancer: a therapeutic point of view

Raee,

Tan,

Najafi

et al. 2023

Reprod Biol Endocrinol

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Autophagy is a highly conserved, lysosome-dependent biological mechanism involved in the degradation and recycling of cellular components. There is growing evidence that autophagy is related to male reproductive biology, particularly spermatogenic and endocrinologic processes closely associated with male sexual and reproductive health. In recent decades, problems such as decreasing sperm count, erectile dysfunction, and infertility have worsened. In addition, reproductive health is closely related to overall health and comorbidity in aging men. In this review, we will outline the role of autophagy as a new player in aging male reproductive dysfunction and prostate cancer. We first provide an overview of the mechanisms of autophagy and its role in regulating male reproductive cells. We then focus on the link between autophagy and aging-related diseases. This is followed by a discussion of therapeutic strategies targeting autophagy before we end with limitations of current studies and suggestions for future developments in the field.

show abstract

Association of serum prostate-specific antigen (PSA) level and circulating tumor cell-based PSA mRNA in prostate cancer

Cited by 12 publications

References 34 publications

Management of a localized prostatic adenocarcinoma despite the very high rate of PSA and the large tumor mass: Does PSA level indicate the stage of prostate cancer?

Management of a localized prostatic adenocarcinoma despite the very high rate of PSA and the large tumor mass: Does PSA level indicate the stage of prostate cancer?

Study on the Diagnostic Value of Contrast-Enhanced Ultrasound and Magnetic Resonance Imaging in Prostate Cancer

Autophagy, a critical element in the aging male reproductive disorders and prostate cancer: a therapeutic point of view

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