Association of serum phosphorus, calcium and parathyroid hormone with cardiovascular calcification in regular hemodialysis patients

Nematollahi, Alireza; Tamadon, Mohammad-Reza; Irannejad, Parisa; Fouladgar, Milad; Bahadoram, Mohammad; Mardani, Saeed

doi:10.15171/jpd.2018.17

Cited by 3 publications

(4 citation statements)

References 11 publications

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“…The differences can be due to the therapeutic effects of medications given to the patients in various study groups as a part of CKD treatment. In our study, we multiplied calcium by phosphorus in hemodialysis patients and the result was 40 mg 2 /dl 2. In a similar study by Nematollahi [10] it was 44 units. The study of Block et al [20] inferred that every 10 units of Ca×PO4 product increase, the mortality rate of hemodialysis patients increased by 7%.…”

Section: Discussionmentioning

confidence: 74%

“…However serum PTH levels were elevated in 70% cases of CKD patients with cardiac abnormalities. Nematollahi et al [10] had found significant positive relationship with the calcification of the heart valves with serum phosphorous. He also found serum phosphorus level had a significant relationship with left ventricular systolic dysfunction.…”

Section: Discussionmentioning

confidence: 95%

“…Hypertensive heart disease with systolic dysfunction accounted for 22% of cases followed by IHD ( 20%) and calcified valves(10%). A study conducted by Nematollahi et al [10] showed aortic valve calcification, mitral valve calcification, and mitral annulus calcification in 20%, 1%, and 4% of hemodialysis patients, respectively. In another study conducted by Jalali et al [11] , mitral valve calcification and aortic valve calcification were observed in 3.9% and 1.9% respectively in hemodialysis patients.…”

Section: Discussionmentioning

confidence: 97%

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Association of serum calcium, phosphrous and parathyroid hormone with cardiac abnormality in CKD patients: A pilot study

Jm¹,

Sharvani²

2021

Int. J. Adv. Res. Med.

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Chronic kidney disease is commonly associated with increase in blood phosphate levels. In early stages phosphate levels are maintained in normal limits because of the hyperparathyroidism causing phosphaturia. With advancement in renal disease hyperphosphatemia becomes evident. As a consequence of same there will be worsening of hyperparathyroidism and predisposition to develop metastatic calcification. In this study we have analyzed the serum levels of Calcium, Phosphorous and Parathormone levels in chronic kidney disease patients who were evaluated in nephrourology centre over a period of one month. It was then evaluated to see the correlation between aforementioned parameters with cardiovascular disease in those patients. The study showed significant correlation between the serum phosphate levels with cardiovascular morbidity in study population but didn't show significant relation with serum calcium and parathormone levels. From the study it can be concluded that a large percentage of end stage renal disease patients have high phosphate levels and this plays a significant role in cardiovascular morbidity in them.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Association of serum calcium, phosphrous and parathyroid hormone with cardiac abnormality in CKD patients: A pilot study

Jm¹,

Sharvani²

2021

Int. J. Adv. Res. Med.

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show abstract

“…Mousavi Movahed et al observed no significant relationship between serum calcium levels with heart disease and the calcification of heart valves (27). However, the results of studies performed by Zand Parsa et al and Nematollahi et al showed a direct linear relationship between calcium levels and the severity of heart disease in these patients (28,29). The difference in sample size in these two studies could cause this discrepancy in the results.…”

Section: Discussionmentioning

confidence: 91%

Evaluation of the Relationship Between Changes in Potassium Concentration and Arrhythmia During Coronary Artery Bypass Grafting Surgery

et al. 2022

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Background: Coronary artery bypass grafting (CABG) surgery is a treatment option for coronary artery diseases. Cardiac arrhythmias during CABG surgery can lead to serious complications. Potassium ion concentration is a factor involved in such arrhythmias. Objectives: This study aimed to investigate the relationship between potassium concentration and cardiac arrhythmias in CABG surgery. Methods: This descriptive cross-sectional study was performed on 60 patients with the American Society of Anesthesiologists class I, II, and III undergoing CABG surgery at Golestan Hospital, Ahvaz, Iran. All patients underwent general anesthesia, and ventilator control was achieved by mechanical ventilation. The on-pump method was used for CABG. Potassium levels were measured at several time points during surgery. All cardiac arrhythmias were recorded. Mean arterial pressure (MAP), serum level of potassium, blood sugar, blood urea nitrogen (BUN), creatinine, calcium, magnesium, hemoglobin (Hb), and sodium were also recorded. Results: The mean age of the patients was 60.87 ± 7.35 years, and 45% of the subjects were female. Moreover, there was no statistically significant difference between the patients. There was a significant relationship between the changes in MAP, potassium, blood sugar, BUN, creatinine, calcium, and magnesium with the incidence of cardiac arrhythmias (P < 0.05). However, no significant relationship was noted between Hb and sodium levels with the incidence of cardiac arrhythmias (P < 0.05). Conclusions: The changes in potassium levels increase the risk of cardiac arrhythmias and their complications.

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Echocardiographic assessment of patients with end-stage renal disease undergoing maintenance hemodialysis

Bhandari,

Pantha,

Pandey

et al. 2023

MEDINDIA

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Objectives: Chronic kidney disease is a global health problem. End-stage renal disease (ESRD) patients have a high frequency of cardiac functional and structural abnormalities associated with higher mortality. Echocardiography is a valuable tool to assess cardiac structural and functional changes, which helps in stratifying prognostic risk factors and measuring the effectiveness of therapeutic intervention. Materials and Methods: We conducted a prospective, cross-sectional, hospital-based study for 1 year from 2076/11/05 to 2077/11/05 B.S (February 17, 2020, to February 17, 2021, A.D. Total of 65 patients with the diagnosis of ESRD undergoing maintenance hemodialysis (MHD) at Chitwan Medical College Hospital meeting inclusion criteria were enrolled. Detailed history, examinations, echocardiographic, and laboratory findings were recorded, and their association was compared with different explanatory variables. Data were analyzed using Statistical Package for the Social Sciences version 25. Results: The most common echocardiography finding among the 65 patients was valvular heart disease (VHD) (78.50%). Among them, 86.2% were undergoing hemodialysis (HD) twice weekly. About 92.7% had hypertension and 52.3% had diabetes mellitus. All had anemia with a mean hemoglobin of 7.86 ± 1.30 g/dL. The most common echocardiography finding was VHD (78.50%). There were statistically significant associations between the age of patients with a prevalence of VHD and systolic dysfunction; the presence of global hypokinesia with body mass index; and the presence of left ventricular hypertrophy (LVH) with calcium levels. Furthermore, a statistically significant difference in the duration of HD was observed with LVH. Conclusion: Cardiovascular diseases are the major cause of morbidity and mortality among ESRD patients undergoing MHD. The study identifies various factors influencing echocardiographic parameters in ESRD patients and highlights VHD as the most prevalent echocardiographic finding. It also emphasizes the importance of echocardiography as a valuable tool for assessing cardiac changes in these patients, aiding in risk stratification and the evaluation of therapeutic interventions.

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Association of serum phosphorus, calcium and parathyroid hormone with cardiovascular calcification in regular hemodialysis patients

Cited by 3 publications

References 11 publications

Association of serum calcium, phosphrous and parathyroid hormone with cardiac abnormality in CKD patients: A pilot study

Association of serum calcium, phosphrous and parathyroid hormone with cardiac abnormality in CKD patients: A pilot study

Evaluation of the Relationship Between Changes in Potassium Concentration and Arrhythmia During Coronary Artery Bypass Grafting Surgery

Echocardiographic assessment of patients with end-stage renal disease undergoing maintenance hemodialysis

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