Association of Serum Pentraxin 3 Concentrations with Diabetic Nephropathy

Wang, Rui; Jietao, Zhang; Hu, Wenchao

doi:10.1136/jim-2016-000082

Cited by 11 publications

(17 citation statements)

References 22 publications

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“…This study showed that patients with DN had significantly higher ages as compared to the control group and the diabetic without DN group. These results are in agreement with Wang et al [12], unlike Abu Seman et al's [14] study which showed that there was no significant age difference between groups.…”

Section: Discussionsupporting

confidence: 92%

“…Thus, there is a need to implement effective strategies being able to prevent DN and to identify specific and early predictors. The etiology of DN is multifactorial, but reported risk factors include increased duration of DM, as well as severity of hypertension and hyperglycemia [12]. Dyslipidemia is a powerful risk factor for atherosclerosis and related disorders such as ischemic heart disease, cerebrovascular diseases, renal disease, and retinal atherosclerosis [13].…”

Section: Discussionmentioning

confidence: 99%

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Study of serum pentraxin 3 level in patients with diabetic nephropathy

et al. 2020

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Background: Pentraxin 3 (PTX3), a member of a superfamily of conserved proteins called pentraxins. PTX3 and Creactive protein (CRP) are members of this family and play an important role in the innate immune system. PTX3 is classified as a long pentraxin, while CRP is a short pentraxin. PTX3 is reported to be a vascular inflammatory marker providing prognostic information of vasculopathy, such as diabetic nephropathy (DN). The purpose of this study is to evaluate the association between serum PTX3 concentrations and the development and/or progression of DN. A total number of 66 patients with type 2 diabetes mellitus (T2DM) and 22 healthy subjects were enrolled in this study. Patients with T2DM were divided, according to the levels of urinary albumin/creatinine ratio (UACR), into three groups: normoalbuminuric, microalbuminuric, and macroalbuminuric groups. Serum PTX3 and high-sensitivity C-reactive protein (hs-CRP) concentrations were determined using ELISA kits. Results: Serum PTX3 and hs-CRP concentrations were significantly higher in patients with T2DM compared with the controls. Furthermore, serum PTX3 concentrations were significantly higher in macroalbuminuric patients than in microalbuminuric patients (P < 0.001) and also were significantly higher in microalbuminuric patients than in normoalbuminuric patients (P < 0.001). However, there were no significant differences between controls and T2DM patients with normoalbuminuria regarding serum PTX3 concentrations (P > 0.05). Moreover, like PTX3, hs-CRP concentrations were higher in microalbuminuric patients than in normoalbuminuric patients (P < 0.05), and also, there were no significant differences between controls and T2DM patients with normoalbuminuria regarding hs-CRP concentrations (P > 0.05). But, unlike PTX3, there were no significant differences between macroalbuminuric and microalbuminuric patients regarding hs-CRP concentrations (P > 0.05). Conclusions: Serum PTX3 is positively associated with DN development and progression, and may be a more accurate predictor of DN development than hs-CRP as it can discriminate between macroalbuminuric and microalbuminuric DN patients, while hs-CRP cannot.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Study of serum pentraxin 3 level in patients with diabetic nephropathy

et al. 2020

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“…In humans, expression of PTX3 is also observed in primary proximal renal tubular epithelial cells (PTECs), primary mesangial cells, and renal fibroblasts in kidney tissues [ 23 , 24 ]. Furthermore, increased plasma levels of PTX3 were observed in patients with CKD [ 11 – 13 ] and DN [ 12 , 14 , 25 ]. In addition, plasma PTX3 levels and urinary protein excretion can normalize though the treatment of the renin-angiotensin system, and/or with calcium channel blockers can normalize in patients with type 2 diabetes who show proteinuria [ 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have suggested that DN is a low-grade chronic inflammatory disease [ 8 , 9 ]. Altered plasma levels of PTX3 are associated with development of DN [ 6 , 10 , 11 ]; plasma PTX3 levels are inversely associated with eGFR, but positively associated with levels of albuminuria/proteinuria in patients with DN. Hence, PTX3 may be implicated in the development of DN.…”

Section: Introductionmentioning

confidence: 99%

Association of Pentraxin 3 Gene Polymorphisms with Susceptibility to Diabetic Nephropathy

et al. 2017

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Background:Diabetic nephropathy (DN) is a major microvascular complication of diabetes. Pentraxin 3 (PTX3) is a member of the acute-phase reactants superfamily and altered plasma levels of PTX3 are associated with DN. We performed a case-control study to analyze the relationship between single nucleotide polymorphisms (SNPs) in PTX3 and the risk for DN in patients with type 2 diabetes. Material/Methods:The study included 135 DN patients, 155 non-diabetic nephropathy (NDN) patients, and 152 normal controls (NC) (N=442). We genotyped eight PTX3 SNPs (rs2305619, rs2120243, rs1456099, rs7634847, rs1840680, rs2316706, rs2316709, and rs7616177) using the ABI PRISM SNapshot method. Results:The genotype frequencies of rs2305619 and rs2120243 differed significantly between the DN and the NDN groups (p=0.017 and p=0.033, respectively). Patients with the GG variant of rs2305619 showed 4.078-fold higher susceptibility to DN than those with the AA variant (OR=4.078, 95% CI=1.370-12.135, p=0.012); patients with the AA variant of rs2120243 had a lower risk of developing DN (OR=0.213, p=0.025).Haplotype analysis showed an association between the CAGGG haplotype in block 1 with DN (p=0.0319). Conclusions:Our findings suggested that PTX3 polymorphisms were associated with an increased risk for DN in Chinese patients with type 2 diabetes.

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“…But at the same time it has been shown that diabetic vascular complications apart from DR also affect the serum levels of PTX3 protein. [38][39][40] Another limitation of our study was its relatively small sample size. It was because of PTX3 levels might be affected by several systemic diseases such as cardiovascular or cerebrovascular diseases, chronic kidney and liver failure, autoimmune disorders, irregular systemic hypertension.…”

Section: Eyementioning

confidence: 97%

Aqueous humor pentraxin-3 levels in patients with diabetes mellitus

Mutlu

Yüksel

Takmaz

et al. 2017

Eye

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PurposeTo evaluate aqueous humor (AH) pentraxin-3 (PTX3) levels in diabetic patients with and without diabetic retinopathy (DR).MethodsIn this prospective study, patients undergoing cataract surgery were enrolled. The study group was composed of 26 type-2 diabetic patients without DR (group 1), 32 diabetic patients with DR (group 2) and 29 age-matched subjects without any systemic disease (group 3). Fifteen proliferative DR (PDR) and 17 non-proliferative DR (NPDR) patients were enrolled in Group 2. HbA1c levels and duration of diabetes were noted. AH samples were obtained from anterior chamber at the beginning of cataract surgery and PTX3 levels were analyzed with Elisa kit.ResultsBaseline demographic characteristics were similar between groups. The mean duration of diabetes was 11.9±7.9 years in group 1 and 15.8±7.8 years in group 2 (P=0.11). The mean plasma HbA1c levels in group 1 was 9.1±2.6 and 8.2±2.4 in group 2 (P=0.36). PTX3 levels were 5.75±0.41 in group 1, 6.11±1.47 in group 2 and 4.93±0.84 ng/ml in group 3 (P=0.01). PTX3 levels in group 2 were higher than in group 1 and 3 (P=0.06 and P=0.01, respectively). There was no correlation between HbA1c and PTX3 levels (P=0.06 r=0.57, P=0.19 r=0.3, respectively). The mean PTX3 was 6.6±0.3 in PDR group and 5.6±0.5 ng/ml in NPDR group (P=0.04).ConclusionsPTX3 is an important marker especially for vascular endothelial damage. Since diabetic vascular changes are dependent on endothelial cell damage, high levels of AH PTX3 of DR patients may indicate the importance of PTX3 protein in the pathogenesis of DR.

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Association of Serum Pentraxin 3 Concentrations with Diabetic Nephropathy

Cited by 11 publications

References 22 publications

Study of serum pentraxin 3 level in patients with diabetic nephropathy

Study of serum pentraxin 3 level in patients with diabetic nephropathy

Association of Pentraxin 3 Gene Polymorphisms with Susceptibility to Diabetic Nephropathy

Aqueous humor pentraxin-3 levels in patients with diabetes mellitus

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