Association of Serum Oxidized Lipoprotein(a) Concentration with Coronary Artery Disease: Potential Role of Oxidized Lipoprotein(a) in the Vasucular Wall

Morishita, Ryuichi; Ishii, Junichi; Kusumi, Yoshiaki; Yamada, Shingo; Komai, Norio; Ohishi, Minako; Nomura, Masatoshi; Hishida, Hitoshi; Niihashi, Mari; Mitsumata, Masako

doi:10.5551/jat.no224

Cited by 28 publications

(35 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using this antibody, they developed a ELISA to measure Lp(a) modified by oxidative stress, and found that hypertensive patients with complications showed a significantly higher level of oxidized Lp(a) in serum than did normotensive subjects, whereas there was no significant difference in native Lp(a) between normotensive and hypertensive subjects. Morishita R et al [38] reported that ox-Lp(a) level in CAD patients with diabetes mellitus was significantly higher than in healthy volunteers. Moreover, serum ox-Lp(a) concentration showed a significant positive correlation with pulse wave velocity, an index of arteriosclerosis .…”

Section: Oxidized Lp(a) Assaymentioning

confidence: 99%

“…The degree of oxidized apo(a) or apoB protein of Lp(a) has been detected to estimate circulating ox-Lp(a) levels [37][38][39][40]. Yamada et al [37] obtained a new 161E2 monoclonal antibody to react with oxidized Lp(a) but not with native Lp(a).…”

Section: Oxidized Lp(a) Assaymentioning

confidence: 99%

“…Moreover, the concentration of serum apo(a) epitope of ox-Lp(a) was reported to be significantly increased in hypertensive patients with complications and CAD patients with diabetes mellitus [37,38]. ApoB protein of plasma Lp(a) was also found oxidized and was a characteristic of the patients with endstage renal disease undergoing continuous ambulatory peritoneal dialysis [39].…”

Section: The Clinical Value Of Circulating Oxidized Lp(a)mentioning

confidence: 99%

See 2 more Smart Citations

Lipoprotein(a) Oxidation, Autoimmune and Atherosclerosis

Wang¹

2012

Coronary Artery Disease - New Insights and Novel Approaches

View full text Add to dashboard Cite

IntroductionLipoprotein(a) [Lp(a)] is a plasma lipoprotein whose structure and composition closely resembles that of low density lipoprotein (LDL), but with one of additional molecule of apolipoprotein(a) [apo(a)], a large glycoprotein linked to apoB by a disulfide bond (Figure 1) [1,2]. High Lp(a) levels have been established as an independent risk factor for atherocslerosis [3][4][5], and Lp(a) deposits have been found in atherosclerotic lesions but not in normal arterial walls [6][7][8].Lp(a) can be modified by oxidation in vitro, and then be taken up by macrophages by means of scavenger receptors, where it promotes their transformation into foam cells within the arterial walls [9][10][11][12][13]. Oxidized Lp(a) [ox-Lp(a)] may also induce adhesion molecular expression on monocytes, promoting their recruitment and adhesion to the endothelium [14], and influence the responsiveness of platelets to various agonists [15]. Modified forms of Lp(a), some resembling oxidized Lp(a), have been identified in human atheromatous lesions [16]. In addition, ox-Lp(a) causes significant changes in apo(a) conformation, which could enhance the interaction of these particles with plasminogen binding sites as well as macrophage scavenger receptors, resulting in increased inhibitory effect on plasminogen activation and finally leading to attenuate fibrinolytic activity [17].Ox-Lp(a) has been reported to play more potent role than native Lp(a) in atherosclerosis [10,14,17,18], and autoantibodies against ox-Lp(a), Lp(a) immune complexes [Lp(a)-IC] have also been detected in vivo simultaneously [19,20]. The present review article focuses specifically on the relationship between Lp(a) oxidation, autoimmune and atherosclerosis together with our recent work. The pathogenic role of oxidized Lp(a)Lp(a) contains a large specific glycoprotein called apo(a), attached by a single disulfide bridge to apoB 100 of LDL (Figure 1). The adverse cardiovascular qualities of Lp(a) have been related to both its LDL-like properties (i.e., formation of foam cells) and its presumed role in fibrinolysis. www.intechopen.comCoronary Artery Disease -New Insights and Novel Approaches 50 Lp(a) oxidationThe structure, fatty acid composition, and antioxidant concentrations of Lp(a) and LDL are quite similar [21]. In vitro studies have shown that Lp(a) can be modified by oxidation (both chemical and cellular-mediated) in a fashion similar to LDL [22]. This modification, which involved lipid peroxidation measured as thiobarbituric acid-reactive substances (TBARS), caused marked changes in the structure and biological properties of Lp(a). Relative to native Lp(a), oxidized particles showed decreases of free amino groups and protein fragmentation, increased negative charge, and high aggregation ability. They were taken up and degraded readily by human monocyte/macrophages by means of scavenger receptors, a known pathway for clearance of ox-LDL in atheroma, inducing cholesteryl ester accumulation and promoting their transformation into foam cells within the arterial w...

show abstract

Section: Oxidized Lp(a) Assaymentioning

confidence: 99%

Section: Oxidized Lp(a) Assaymentioning

confidence: 99%

Section: The Clinical Value Of Circulating Oxidized Lp(a)mentioning

confidence: 99%

See 1 more Smart Citation

Lipoprotein(a) Oxidation, Autoimmune and Atherosclerosis

Wang¹

2012

Coronary Artery Disease - New Insights and Novel Approaches

View full text Add to dashboard Cite

show abstract

“…In fact elevated Lp(a) level is believed to promote atherosclerosis via Lp(a)-derived cholesterol entrapment in the intima, inflammatory cell recruitment and/or via the binding of pro-inflammatory-oxidised LDL (17)(18)(19)(20)(21)(22). Elevated Lp(a) level promote also thrombosis via the inhibition of fibrinolysis with enhancement of clot stabilization as well as via enhancement coagulation via the inhibition of tissue factor pathway inhibitor.…”

Section: Editorialmentioning

confidence: 99%

Reduction of cardiovascular risk in subjects with high lipoprotein (a) levels

et al. 2017

View full text Add to dashboard Cite

“…Ox-Lp(a) levels have been reported to be present in newborns and children 11) , and increased in rheumatoid arthritis patients with excessive cardiovascular events 12) . Furthermore, elevated ox-Lp(a) levels have been found to be associated with the presence of stable coronary artery disease (CAD) and acute coronary syndromes (ACS), and with the severity of ACS [13][14][15] .…”

Section: Introductionmentioning

confidence: 99%